Genetic and molecular biology of breast cancer among Iranian patients

Moghbeli, Meysam

doi:10.1186/s12967-019-1968-2

Cited by 18 publications

(11 citation statements)

References 263 publications

(249 reference statements)

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“…The most common cellular and molecular processes involved in tumour progression are non-coding RNAs, epigenetic modifications, and immune responses. Among the 117 genes studied, only about 10% are estimated to be high risk factors for the initiation of carcinogenesis (Moghbeli et al, 2019).…”

Section: Gene Mutations Are a Key Factor In Tumorigenesismentioning

confidence: 99%

A modern look at the molecular-biological mechanisms of breast tumours in dogs

Bilyi

Gerdeva

Samoilіuk

et al. 2020

Regul. Mech. Biosyst.

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High morbidity and increase in the number of registrations of breast tumours in dogs, their wide application as biological models, discussion of numerous questions of oncogenesis, and the lack of a uniform/unified methodological approach to the study of molecular and biological mechanisms of treatment of cancer determine the relevance of the problem of cancer both in humans and in our domestic companions. The analysis of publications allowed us to establish the following patterns of carcinogenesis. The peculiarities of the biological behaviour of breast tumours depend on their pathomorphological structure. Genetic predisposition to breast cancer is characteristic only in the single breed aspect. Environmental factors are of critical relevance to carcinogenesis : chemical pollutants initiate oncogenesis indirectly – by altering the expression of several receptors, impaired endocrine balance and direct mutagenic effects. Reproductive status plays a key role in the initiation and progression of breast tumours by reducing the expression of estrogen, progesterone and prolactin receptor genes. The inflammatory response that accompanies the neoplasia process is characterized by increased production of cytokines, cyclooxygenase-2, interleukins (IL-1, IL-6, IL-8), vascular endothelial growth receptors, and impaired hemostatic status (oxidative stress), which promotes progression of disease. In breast cancer in dogs, genomic instability leads to genomic aberrations, and subsequently, mutations that support the proliferation, survival and dissemination of neoplastic cells. The initiation and progression of mammary gland tumours is provided by cancer stem cells by disrupting the regulation of precursor cell self-renewal, which also predispose to resistance to chemotherapeutic agents, radiation, and hormonal cancer therapy. The analysis of the publications revealed the major markers of carcinogenesis that could potentially be used as biological targets for the design of modern diagnostic strategies and high-performance therapeutic protocols.

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Section: Gene Mutations Are a Key Factor In Tumorigenesismentioning

confidence: 99%

A modern look at the molecular-biological mechanisms of breast tumours in dogs

Bilyi

Gerdeva

Samoilіuk

et al. 2020

Regul. Mech. Biosyst.

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“…Chemotherapy is an effective method of tumor therapy, but some tumors cannot be treated effectively due to multidrug resistance (MDR) [ 1 , 2 ]. A chemotherapeutic failure of about 85–90% has been reported for solid tumors [ 3 ], making this the main reason for tumor relapse, metastasis and poor clinical outcomes for patients.…”

Section: Introductionmentioning

confidence: 99%

Long non-coding RNAs as the critical regulators of doxorubicin resistance in tumor cells

Khalili-Tanha

Moghbeli

2021

Cell Mol Biol Lett

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Resistance against conventional chemotherapeutic agents is one of the main reasons for tumor relapse and poor clinical outcomes in cancer patients. Various mechanisms are associated with drug resistance, including drug efflux, cell cycle, DNA repair and apoptosis. Doxorubicin (DOX) is a widely used first-line anti-cancer drug that functions as a DNA topoisomerase II inhibitor. However, DOX resistance has emerged as a large hurdle in efficient tumor therapy. Furthermore, despite its wide clinical application, DOX is a double-edged sword: it can damage normal tissues and affect the quality of patients’ lives during and after treatment. It is essential to clarify the molecular basis of DOX resistance to support the development of novel therapeutic modalities with fewer and/or lower-impact side effects in cancer patients. Long non-coding RNAs (lncRNAs) have critical roles in the drug resistance of various tumors. In this review, we summarize the state of knowledge on all the lncRNAs associated with DOX resistance. The majority are involved in promoting DOX resistance. This review paves the way to introducing an lncRNA panel marker for the prediction of the DOX response and clinical outcomes for cancer patients.

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“…Smoking and overweight are the most important environmental risk factors for lung and gastric cancers in Iranian subjects [8,9]. Beside the environmental factors, genetic and epigenetic factors are also involved in cancer susceptibility among Iranians [10][11][12]. Family history has been reported as a risk factor for breast cancer among Iranian patients [13].…”

Section: Introductionmentioning

confidence: 99%

Long non-coding RNAs as the critical factors during tumor progressions among Iranian population: an overview

2020

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Background: Cancer is associated with various genetic and environmental risk factors. Beside the mutations or aberrant expression of protein-coding genes, the genetic deregulation of non-coding RNAs has also an important role during tumor progression and metastasis. Long non-coding RNAs (lncRNAs) are a class of ncRNAs larger than 200 nucleotides that may function as tumor-suppressor or oncogene. Main body:There is a raising trend of cancer incidence among Iranian population during the last decades. Therefore, it is required to prepare a general population specific panel of genetic markers for the early detection of cancer in this population. The tissue-specific expression characteristics and high stability in body fluids highlight the lncRNAs as efficient diagnostic and prognostic noninvasive biomarkers in cancer. In present review we summarized all of the lncRNAs which have been reported until now in different tumors among Iranian patients. Conclusions:This review paves the way of introducing a population based noninvasive diagnostic panel of lncRNAs for the early detection of tumor cells among Iranian population.

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Genetic and molecular biology of breast cancer among Iranian patients

Cited by 18 publications

References 263 publications

A modern look at the molecular-biological mechanisms of breast tumours in dogs

A modern look at the molecular-biological mechanisms of breast tumours in dogs

Long non-coding RNAs as the critical regulators of doxorubicin resistance in tumor cells

Long non-coding RNAs as the critical factors during tumor progressions among Iranian population: an overview

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