Genetic and molecular factors and anterior cruciate ligament injuries: current concepts

Global gene expression profiling of blast lung injury of goats exposed to shock wave

“…Type I collagen and type III collagen, the important members of the collagen family are the key structural components of the extracellular matrix 43 and hollow organs such as vessels. 44 , 45 In our study, the expression of COL1A1, COL1A2 and COL3A1 genes were significantly increased, indicating that collagen family was also involved in the process of BLI. The expression of LOC102188986 and LOC102176878 genes were significantly down-regulated, which refers to HLA class II histocompatibility antigen 46 and mast cell protease 3 involving the inflammatory response of BLI.…”

The potential European genetic predisposition for non-contact anterior cruciate ligament injury

“…Individuals with a family history of ACL injury are twice as likely to sustain the same injury [17, 20, 27]. Studies have shown that the genetics of an individual can affect the incidence of ligament lesions [1, 27]. Studies examining patient populations with ACL injury have identified variations in gene expression caused by characteristic genetic polymorphisms, and suggest a DNA‐based predisposition to ACL injury [13, 14, 17, 20, 23, 27].…”

Higher Gene Expression of Healing Factors in Anterior Cruciate Ligament Remnant in Acute Anterior Cruciate Ligament Tear

“…10 We chose to investigate these collagen genes because they all have been related to ACL injury according to a recently published review paper. 4 The LOX, PLOD1 , and PLOD2 genes encode collagen-modifying enzymes (lysyl oxidase, lysyl hydroxylases 1, and lysyl hydroxylases 2, respectively) related to development and formation of crosslink attachment sites used to stabilize fibers of collagen and elastin. 17,34,40 The TGFβ1 and TGFβR1 genes encode transforming growth factor β1 (TGF-β1) and its receptor, respectively.…”