Genetic and pharmacologic alterations of claudin9 levels suffice to induce functional and mature inner hair cells
Yingying Chen,
Jeong Han Lee,
Jin Li
et al.
Abstract:Hearing loss is the most common form of sensory deficit. It occurs predominantly due to hair cell (HC) loss. Mammalian HCs are terminally differentiated by birth, making HC loss incurable. Here, we show the pharmacogenetic downregulation of Cldn9, a tight junction protein, generates robust supernumerary inner HCs (IHCs) in mice. The putative ectopic IHCs have functional and synaptic features akin to typical IHCs and were surprisingly and remarkably preserved for at least fifteen months >50% of the mouse’s l… Show more
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