Genetic Architectures and Cell-of-Origin in Glioblastoma

Kim, Hyun Jung; Lee, Jehee

doi:10.3389/fonc.2020.615400

Cited by 39 publications

(28 citation statements)

References 67 publications

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“…Full GBM surgical resection can be made difficult by the infiltrative nature of these tumors and by the need to preserve essential cognitive functions of the patients. From a cellular standpoint, the difficulty in efficiently treating glioblastoma also stems from the high heterogeneity and plasticity of these tumors, beyond the still debated question of the cell of origin of these tumors [ 141 , 142 , 143 , 144 , 145 , 146 ].…”

Section: Brain Tumorsmentioning

confidence: 99%

Intercellular Communication in the Brain through Tunneling Nanotubes

Khattar

Safi

Rodriguez

et al. 2022

Cancers

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Intercellular communication is essential for tissue homeostasis and function. Understanding how cells interact with each other is paramount, as crosstalk between cells is often dysregulated in diseases and can contribute to their progression. Cells communicate with each other through several modalities, including paracrine secretion and specialized structures ensuring physical contact between them. Among these intercellular specialized structures, tunneling nanotubes (TNTs) are now recognized as a means of cell-to-cell communication through the exchange of cellular cargo, controlled by a variety of biological triggers, as described here. Intercellular communication is fundamental to brain function. It allows the dialogue between the many cells, including neurons, astrocytes, oligodendrocytes, glial cells, microglia, necessary for the proper development and function of the brain. We highlight here the role of TNTs in connecting these cells, for the physiological functioning of the brain and in pathologies such as stroke, neurodegenerative diseases, and gliomas. Understanding these processes could pave the way for future therapies.

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Section: Brain Tumorsmentioning

confidence: 99%

Intercellular Communication in the Brain through Tunneling Nanotubes

Khattar

Safi

Rodriguez

et al. 2022

Cancers

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“…The existence of these cells is a subject of controversy, due to lack of specific markers or standard identification strategies. However, the presence of CSCs has been consistently demonstrated in several cancers, such as leukemia, glioblastoma, breast, ovarian, colorectal, prostate, lung, liver, and kidney cancers [28][29][30][31][32][33], and it appears that CSCs are also present in OS. Specifically, OS CSCs share similarities with mesenchymal stem cells (MSCs), which points to a probable bone-marrow MSC and/or mesenchymal progenitor cell origin for OS CSCs [10,11,[34][35][36][37].…”

Section: Osteosarcoma Overviewmentioning

confidence: 99%

Avenues of research in dietary interventions to target tumor metabolism in osteosarcoma

et al. 2021

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Osteosarcoma (OS) is the most frequent primary bone cancer, affecting mostly children and adolescents. Although much progress has been made throughout the years towards treating primary OS, the 5-year survival rate for metastatic OS has remained at only 20% for the last 30 years. Therefore, more efficient treatments are needed. Recent studies have shown that tumor metabolism displays a unique behavior, and plays important roles in tumor growth and metastasis, making it an attractive potential target for novel therapies. While normal cells typically fuel the oxidative phosphorylation (OXPHOS) pathway with the products of glycolysis, cancer cells acquire a plastic metabolism, uncoupling these two pathways. This allows them to obtain building blocks for proliferation from glycolytic intermediates and ATP from OXPHOS. One way to target the metabolism of cancer cells is through dietary interventions. However, while some diets have shown anticancer effects against certain tumor types in preclinical studies, as of yet none have been tested to treat OS. Here we review the features of tumor metabolism, in general and about OS, and propose avenues of research in dietary intervention, discussing strategies that could potentially be effective to target OS metabolism.

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“…Several studies have shown that metabolic and genetic disorders there are in patients with diabetes and cancer [14][15][16]. In addition, circRNAs can exert modulatory effects on cancer-related processes, such as tumorigenesis, tumor progression, and apoptosis [17,18].…”

Section: Introductionmentioning

confidence: 99%

Circular RNAs and glioblastoma multiforme: focus on molecular mechanisms

Salami

Mafi

et al. 2022

Cell Commun Signal

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Glioblastoma multiforme (GBM), as a deadly and almost incurable brain cancer, is the most invasive form of CNS tumors that affects both children and adult population. It accounts for approximately half of all primary brain tumors. Despite the remarkable advances in neurosurgery, radiotherapy, and chemotherapeutic approaches, cell heterogeneity and numerous genetic alterations in cell cycle control, cell growth, apoptosis, and cell invasion, result in an undesirable resistance to therapeutic strategies; thereby, the median survival duration for GBM patients is unfortunately still less than two years. Identifying new therapeutics and employing the combination therapies may be considered as wonderful strategies against the GBM. In this regard, circular RNAs (circRNAs), as tumor inhibiting and/or stimulating RNA molecules, can regulate the cancer-developing processes, including cell proliferation, cell apoptosis, invasion, and chemoresistance. Hereupon, these molecules have been introduced as potentially effective therapeutic targets to defeat GBM. The current study aims to investigate the fundamental molecular and cellular mechanisms in association with circRNAs involved in GBM pathogenesis. Among multiple mechanisms, the PI3K/Akt/mTOR, Wnt/β-catenin, and MAPK signaling, angiogenic processes, and metastatic pathways will be thoroughly discussed to provide a comprehensive understanding of the role of circRNAs in pathophysiology of GBM.

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Genetic Architectures and Cell-of-Origin in Glioblastoma

Cited by 39 publications

References 67 publications

Intercellular Communication in the Brain through Tunneling Nanotubes

Intercellular Communication in the Brain through Tunneling Nanotubes

Avenues of research in dietary interventions to target tumor metabolism in osteosarcoma

Circular RNAs and glioblastoma multiforme: focus on molecular mechanisms

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