Genetic aspects of bladder cancer progression

Lerner, Seth P.; Tsai, Yvonne; Jones, Peter A.

doi:10.1007/bf00184036

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Molecular Mechanism Of Progression O F Bladder Cancer2

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1995

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“…52 Of the 28 tumors with LOH, 26 were muscleinvasive, while only two out of 48 (14%) superficial tumors showed RB allele loss, one progressing rapidly to invasive disease. These results show that LOH at the RB locus is a frequent genetic event in bladder cancers and may identify a subset of more aggressive tumors.…”

Section: Molecular Mechanism Of Progression O F Bladder Cancermentioning

confidence: 94%

“…With the use of banding techniques, aberrations can be assigned to specific chromosomes and significant non-random abnormalities have been identified on chromosomes 1, 3, 5 , 7, 9, 11 and 17.52 Cairns et al examined 162 bladder cancers for evidence of structural alterations to the RB gene; 94 were informative, and 28 (29%) of these showed loss of heterozygosity (LOH) . 52 Of the 28 tumors with LOH, 26 were muscleinvasive, while only two out of 48 (14%) superficial tumors showed RB allele loss, one progressing rapidly to invasive disease. These results show that LOH at the RB locus is a frequent genetic event in bladder cancers and may identify a subset of more aggressive tumors.…”

Section: Molecular Mechanism Of Progression O F Bladder Cancermentioning

confidence: 94%

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