Genetic Aspects of Cleft Lip and Palate ? A Review

Abstract

Craniofacial abnormalities especially Cleft Lip and Palate (CLP) are considered to be one of the most commonly occurring birth defects in humans. CLP is considered to be a very important disorder to be understood because of the the complications it produces in an infant. Recent advances in molecular techniques has given a good insight into the various changes that occur at a genetic level, thus shedding some light on the pathogenesis of CLP. This review aims to give the reader an uptodate information regrading various genes that are involved in oro facial clefting especially CLP.