Genetic association between CELF4 rs1557341 polymorphism and neuroticism in Chinese Han population

An, L.; Chen, Zhixuan; Zhang, Naixin; Ren, Decheng; Yuan, Fan; Yuan, Ruixue; Bi, Yan; Ji, Lei; Guo, Zhenming; Ma, Gaini; Xu, Fei; Yang, Fengping; Liu, Chuanxin; Xu, Yifeng; He, Lin; Bai, Bo; Yu, Tao; He, Guang

doi:10.1016/j.psychres.2018.12.136

Cited by 5 publications

(3 citation statements)

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“…This study is part of an ongoing school-based cohort study, the Decoding Happiness Gene Cohort Study (DHGCS), which aimed to investigate the longitudinal course of depressive symptoms and happiness as well as their affecting factors 37 , 38 . We recruited college students at the beginning of the first academic year and follow them up after 12 months, from a comprehensive university in Shandong, China (See supplementary Table S1 for details).…”

Section: Methodsmentioning

confidence: 99%

A study of negative life events driven depressive symptoms and academic engagement in Chinese college students

Chen

Hou

et al. 2021

Sci Rep

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Negative life events (NLEs) are an important predictor of depressive symptoms (DS). College students experiencing NLEs are at risk of developing DS that could further weaken their academic engagement (AE), while social supports may assuage such negative effect. The aim of this study was to examine the relationship between negative life events, depressive symptoms, and academic engagement, and how the NLE-DS-AE relationship is affected by the level of social support among Chinese college students. To test this hypothesis, we applied data from the Decoding Happiness Gene Cohort Study (DHGCS). Baseline depressive symptoms and academic engagement were measured at the beginning of the first academic year. Approximately 12 months later, negative life events and social support over the past year were assessed retrospectively along with current depressive symptoms and academic engagement. A total of 3629 college students (Age = 18.67 ± 0.82) were included in the study. The prevalence of depressive symptoms was 26.7% and 36.7% in college students at the beginning of the first and second academic year, respectively. Depressive symptoms predicted subsequent academic engagement rather than the reverse based on cross-lagged analyses. Using structural equation modeling analyses, findings revealed a partial mediation effect of social support between negative life events and the development of depressive symptoms, and a partial mediation effect between negative life events and academic engagement. The findings presented negative life events jeopardize the academic engagement via depressive symptoms, while social supports are able to cancel such negative effect among college students under the Chinese cultural context.

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Section: Methodsmentioning

confidence: 99%

A study of negative life events driven depressive symptoms and academic engagement in Chinese college students

Chen

Hou

et al. 2021

Sci Rep

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“…In a comparison involving the imprinted and housekeeping gene database, we identified 3 DMSs located in 2 imprinted genes ( Table 2 ) and 28 DMSs located in 26 housekeeping genes ( Table 3 ). The two imprinted genes included: (1) NTM , which encoded a protein of the IgLON family with specific expression in the brain that promotes neurite outgrowth and adhesion via a homophilic mechanism ( Li et al, 2015 ; Maruani et al, 2015 ); (2) BRUNOL4 , which was related to variable splicing of precursor RNA and its editing and normal function of the nervous system ( Wang et al, 2016 ; An et al, 2019 ). Among the housekeeping genes, CASP7 , RBM28 , and FEZ2 were associated with the maintenance of nerve function ( Nousbeck et al, 2008 ; Choudhury et al, 2015 ; Hapairai et al, 2017 ).…”

Section: Resultsmentioning

confidence: 99%

Whole-Genome Methylation Analysis Revealed ART-Specific DNA Methylation Pattern of Neuro- and Immune-System Pathways in Chinese Human Neonates

et al. 2021

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The DNA methylation of human offspring can change due to the use of assisted reproductive technology (ART). In order to find the differentially methylated regions (DMRs) in ART newborns, cord blood maternal cell contamination and parent DNA methylation background, which will add noise to the real difference, must be removed. We analyzed newborns’ heel blood from six families to identify the DMRs between ART and natural pregnancy newborns, and the genetic model of methylation was explored, meanwhile we analyzed 32 samples of umbilical cord blood of infants born with ART and those of normal pregnancy to confirm which differences are consistent with cord blood data. The DNA methylation level was lower in ART-assisted offspring at the whole genome-wide level. Differentially methylated sites, DMRs, and cord blood differentially expressed genes were enriched in the important pathways of the immune system and nervous system, the genetic patterns of DNA methylation could be changed in the ART group. A total of three imprinted genes and 28 housekeeping genes which were involved in the nervous and immune systems were significant different between the two groups, six of them were detected both in heel blood and cord blood. We concluded that there is an ART-specific DNA methylation pattern involved in neuro- and immune-system pathways of human ART neonates, providing an epigenetic basis for the potential long-term health risks in ART-conceived neonates.

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“…Neuroticism is defined as a personality trait linked to emotional instability, which is characterized by emotion dysregulation and negative affect [ 1 ]. Neuroticism is one of the major risk factors leading to psychological disorder such as major depressive disorder (MDD), and neuroticism is also related to some physical diseases, including type 1 diabetes and cardiovascular disease [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

Exploring the novel SNPs in neuroticism and birth weight based on GWAS datasets

2023

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Objectives Epidemiological studies have confirmed that low birth weight (BW) is related to neuroticism and they may have a common genetic mechanism based on phenotypic correlation research. We conducted our study on a European population with 159,208 neuroticism and 289,142 birth weight samples. In this study, we aimed to identify new neuroticism single nucleotide polymorphisms (SNPs) and pleiotropic SNPs associated with neuroticism and BW and to provide more theoretical basis for the pathogenesis of the disease. Methods We estimated the pleiotropic enrichment between neuroticism and BW in two independent Genome-wide association studies (GWAS) when the statistical thresholds were Conditional False Discovery Rate (cFDR) < 0.01 and Conjunctional Conditional False Discovery Rate (ccFDR) < 0.05. We performed gene annotation and gene functional analysis on the selected significant SNPs to determine the biological role of gene function and pathogenesis. Two-sample Mendelian Randomization (TSMR) analysis was performed to explore the causal relationship between the neuroticism and BW. Results The conditional quantile–quantile plots (Q-Q plot) indicated that neuroticism and BW have strong genetic pleiotropy enrichment trends. With the threshold of cFDR < 0.001, we identified 126 SNPs related to neuroticism and 172 SNPs related to BW. With the threshold of ccFDR < 0.05, we identified 62 SNPs related to both neuroticism and BW. Among these SNPs, rs8039305 and rs35755513 have eQTL (expressed quantitative trait loci) and meQTL (methylation quantitative trait loci) effects simultaneously. Through GO enrichment analysis we also found that the two pathways of positive regulation of “mesenchymal cell proliferation” and “DNA-binding transcription factor activity” were significantly enriched in neuroticism and BW. Mendelian randomization analysis results indicate that there is no obvious causal relationship between neuroticism and birth weight. Conclusion We found 126 SNPs related to neuroticism, 172 SNPs related to BW and 62 SNPs associated with both neuroticism and BW, which provided a theoretical basis for their genetic mechanism and novel potential targets for treatment/intervention development.

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Genetic association between CELF4 rs1557341 polymorphism and neuroticism in Chinese Han population

Cited by 5 publications

References 5 publications

A study of negative life events driven depressive symptoms and academic engagement in Chinese college students

A study of negative life events driven depressive symptoms and academic engagement in Chinese college students

Whole-Genome Methylation Analysis Revealed ART-Specific DNA Methylation Pattern of Neuro- and Immune-System Pathways in Chinese Human Neonates

Exploring the novel SNPs in neuroticism and birth weight based on GWAS datasets

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