Genetic association between common beta-2 adrenoreceptor polymorphism and asthma severity in school-age children

Salama, Mohamed S.; Ashaat, Neveen A.; Hamad, Aya A.

doi:10.1016/j.ejmhg.2011.07.003

Cited by 5 publications

(3 citation statements)

References 26 publications

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“…(38) Allergy was found as another significant predictor, which proves that the positive history of allergy is a risk factor of asthma severity. (39) Several studies (40)(41)(42) supported the current study whichdetected significant difference among non-obese asthmatic patients in FEV1 %predicted when distributed according to genotypes at codon 16 of the ADRB2; there was a significant increase in FEV1%predicted in Arg16 homozygotes. This is supported by In the present study there was a significant difference in proportion of combined genotype Gly16Arg-Glu27Glu among the four studied groups, however this was mainly due to theeffect of obesity rather than asthma.…”

Section: Discussionsupporting

confidence: 80%

The Role of Beta-2 Adrenergic Receptor Gene Polymorphism in the Pathophysiology of Asthma Associated With Obesity

2015

Journal of the Medical Research Institute

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Background and objectives:: Several mechanisms have been suggested to explain the association between asthma and obesity, one of them is the presence of common genetic predictors as β2 adrenergic receptor gene polymorphism. To test this suggestion, the present study was carried out.Subjects: 60 asthmatic patients (50 females and10 males) and 60 normal subjects (46 females and 14 males) were included in this study. Methodology: measurement of body weight and height, waist circumference and waist to hip ratio. Asthma severity was assessed by disease severity score. Pulmonary function tests and bronchial reactivity by methacholine inhalation challenge (PD 20-FEV1) were performed and DNA extraction, Polymerase chain reaction (PCR)and restriction digestion was performed at codons 16 and 27of β2AR to determine β2 adrenergic receptor gene polymorphism. Results: No significant difference was detected between the asthmatic and control subjects as regards allelic or genotype frequencies of β2AR gene at codon 16 and codon 27 and no significant difference was found as regards genotype frequencies of β2AR gene at codon 16 and codon 27 between obese and non-obese asthmatics. A significantly increased frequency of Gly/Gly at codon 16 was found among severe asthmatics in comparison with mild and moderate asthmatics. A significantly higher frequency of genotype Glu/Glu at codon 27 was detected among obese subjects when compared to non-obese subjects. There was a significant difference in FEV1% predicted and in FEF25-75% predicted in non-obese asthmatics when distributed according to genotypes at codon 16. No significant difference in the distribution of the asthmatics according to the value of PD20-FEV1 among genotypes of B2AR gene at codon 16, codon 27 was found. Conclusion: Arg16Arg was found to be protective from development of severe asthmaGlu27Gluwassignificantly associated with obesity. However, there was no detectable specific genotype for the association of asthma and obesity.

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Section: Discussionsupporting

confidence: 80%

The Role of Beta-2 Adrenergic Receptor Gene Polymorphism in the Pathophysiology of Asthma Associated With Obesity

2015

Journal of the Medical Research Institute

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“…In meta-analysis of 28 studies, authors concluded that carriers of the +46AA genotype had a higher risk of developing severe and nocturnal asthma than carriers of the +46GG genotype [ 14 ]. On the other hand, an Egyptian study in school-age children with asthma had shown an association of the +46GA genotype with severe asthma [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

ADRB2 gene polymorphisms and salbutamol responsiveness in Serbian children with asthma

Jovicic

Babic

Dragičević

et al. 2018

Balkan Journal of Medical Genetics

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Inhaled β2 adrenergic receptor (β2-AR) agonists are the mainstay of asthma therapy. The β2-AR protein is encoded by the ADRB2 gene and variants within this gene can have significant consequences for modulating the response to asthma therapy. This cross-sectional study performed at the University Children’s Hospital in Belgrade, included 54 children with asthma. The subjects were genotyped for ADRB2 +46A>G (Arg16Gly, rs1042713) and +79C>G (Gln27Glu, rs 1042714) polymorphisms and the association with asthma severity and response to inhaled salbutamol was examined. In Serbian asthmatic children, allele +46A was detected with a frequency of 41.7% and allele +79G was detected with a frequency of 23.1%. Allele +46G was found to be associated with a better response to inhaled salbutamol (p <0.05) and with mild form of asthma (p <0.05). Polymorphism ADRB2 +46A>G may be a determinant of asthma severity and response to salbutamol in children with asthma. We did not find any association of +79C>G polymorphisms with the asthma severity and bronchodilator response to inhaled salbutamol. The results of this study can be potentially useful for personalization of asthma treatment.

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“…Recently, an ADRB2 haplotype has been reported to possibly contribute to increased asthma risk in a Chinese population [49]. In addition, in Caucasians the Arg16Gly/Gln27Gln (rs1042713/rs1042714) haplotype was identified as a risk factor to severe asthma exacerbations [50].…”

Section: Discussionmentioning

confidence: 99%

SPINK5andADRB2haplotypes are risk factors for asthma in Mexican pediatric patients

Martínez-Aguilar¹,

Río-Navarro²,

Navarro-Olivos³

et al. 2014

Journal of Asthma

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Genetic association between common beta-2 adrenoreceptor polymorphism and asthma severity in school-age children

Cited by 5 publications

References 26 publications

The Role of Beta-2 Adrenergic Receptor Gene Polymorphism in the Pathophysiology of Asthma Associated With Obesity

The Role of Beta-2 Adrenergic Receptor Gene Polymorphism in the Pathophysiology of Asthma Associated With Obesity

ADRB2 gene polymorphisms and salbutamol responsiveness in Serbian children with asthma

SPINK5andADRB2haplotypes are risk factors for asthma in Mexican pediatric patients

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