Genetic association between interleukin-10 gene promoter region polymorphisms and type 1 diabetes age-at-onset

Ide, Akane; Kawasaki, Eiji; Abiru, Norio; Sun, Fuyan; Takahashi, Ryoko; Kuwahara, Hironaga; Fujita, Naruhiro; Kita, Atsushi; Oshima, Katsuya; Sakamaki, Hiroyuki; Uotani, Shigeo; Yamasaki, Hironori; Yamaguchi, Yoshihiko; Eguchi, Katsumi

doi:10.1016/s0198-8859(02)00417-2

Cited by 52 publications

(41 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, the frequency of the IL-10 -1082 locus G allele was very similar to that reported for Mainland Chinese (Ma et al, 2007) and Japanese (6.5%) (Ide et al, 2002) populations, which largely differ from that in Cambodians (48%) (Delgado et al, 2002) and Turks (37.7%) (Oral et al, 2006). The frequency of the IL-10 -1082 locus G allele mutation was reported to be higher among Chinese individuals (25%) in one study, but the sample size was small and the variation was relatively large.…”

Section: Discussionsupporting

confidence: 90%

Independent and joint effects of the IL-6 and IL-10 gene polymorphisms in pulmonary tuberculosis among the Chinese Han population

Feng¹,

Liu²,

Sun³

et al. 2014

Genet. Mol. Res.

View full text Add to dashboard Cite

ABSTRACT. We investigated the association between interleukin (IL)-6 and IL-10 gene polymorphisms and the susceptibility to pulmonary tuberculosis (PTB). DNA samples were obtained from 191 Han Chinese patients with PTB and 191 healthy control subjects. and IL-10 (-1082, -819) polymorphisms were analyzed using polymerase chain reaction-restriction fragment length polymorphism. The IL-6 -572 C/C and IL-10 -819 T/T genotypes were observed less frequently in the case group than in the control group, with crude odds ratios of 0.591 [95% confidence interval (CI) = 0.381-0.917] and 0.401 (95%CI = 0.257-0.627), respectively. A significant association remained after adjusting for environmental factors in multivariate logistic analysis. The homozygote genotypes

show abstract

Section: Discussionsupporting

confidence: 90%

Independent and joint effects of the IL-6 and IL-10 gene polymorphisms in pulmonary tuberculosis among the Chinese Han population

Feng¹,

Liu²,

Sun³

et al. 2014

Genet. Mol. Res.

View full text Add to dashboard Cite

show abstract

“…Ethnic differences in the haplotype and genotype frequencies within the IL-10 promoter have been reported previously (8,18,25). The genotype frequencies of GG, GA, and AA observed in the Argentinean population were quite similar to the frequencies found in the Brazilian Caucasian population (23).…”

Section: Resultssupporting

confidence: 80%

Gender Susceptibility to Chronic Hepatitis C Virus Infection Associated with Interleukin 10 Promoter Polymorphism

Paladino

Fainboim

Theiler

et al. 2006

J Virol

View full text Add to dashboard Cite

Elevated levels of interleukin 10 (IL-10) were previously described for chronically hepatitis C virus (HCV)-infected patients. We determined by a sequence-specific oligonucleotide probing technique the IL-10 promoter genotypes in 286 Argentinean HCV patients grouped according to disease outcome. The GG genotype (position ؊1082) is known to be associated with high IL-10 production, GA is considered an intermediate producer, and AA is associated with low IL-10 production. We found an increase in frequency of the GG genotype in female patients who do not eliminate the virus (RNA ؉ ). In these patients, the GG frequency was 0.19, versus 0.10 in controls (P ‫؍‬ 0.03). This association became more significant in those RNA ؉ female patients with elevated hepatic transaminases (GG frequency of 0.25; P ‫؍‬ 0.0013). Additionally, this genotype frequency was higher in noncirrhotic female patients than in controls (GG frequency for noncirrhotic female patients was 0.31; P ‫؍‬ 0.009). In RNA ؊ patients, the GA frequency was elevated compared with that in controls (GA frequency of 0.76 in RNA ؊ patients versus 0.48 in controls; P ‫؍‬ 0.01), that in all HCV patients (GA frequency of 0.43; P ‫؍‬ 0.001), and that in RNA ؉ patients (GA frequency of 0.40; P ‫؍‬ 0.0005). We conclude that a gender effect is observed with women carrying the GG high IL-10 producer genotype. The higher levels of IL-10 present in those individuals are associated with a higher risk of an inefficient clearance of the HCV and the development of a chronic HCV infection together with a lower risk of progression to cirrhosis in female patients.

show abstract

“…14 In Table 5, the À1082 G allele frequency is found to be very low in our population compared with others. The frequency of G allele in our population (4%) was similar to that of Korean (7.4%) 22 and Japanese (6.5%), 23 but was significantly different from Caucasians (48%). 24 The G allele frequency in Cambodians is more like that in Caucasians than in other Asian populations, however, there are significant departures from the Hardy-Weinberg equilibrium in both their cases and controls.…”

Section: Association Of Ifn-c and Il-10 With Tuberculosissupporting

confidence: 75%

Association of interferon gamma and interleukin 10 genes with tuberculosis in Hong Kong Chinese

et al. 2005

View full text Add to dashboard Cite

Interferon gamma (IFN-g) and interleukin 10 (IL-10) are believed to play opposing roles in host immunity against mycobacterial infection. IFN-g activates macrophages, while IL-10 downregulates the expression of T helper type 1 cytokines, MHC class II antigens and costimulatory molecules on macrophages. Associations of IFN-g À179 (G/T), þ 874 (A/T), þ 875 miscrosatellite CA repeats and þ 4766 (C/T), and IL-10 À1082 (A/G), À819 (C/T) and À592 (C/A) with tuberculosis (TB) were investigated in 385 HIV-negative patients and 451 controls in a Hong Kong Chinese population. The frequency of a low IFN-g-producing þ 874 A/A genotype was significantly over-represented in the patient group (Po0.001, OR ¼ 3.79, 95% CI ¼ 1.93-7.45). We identified 10 alleles in the IFN-g CA repeats and observed a significant difference in allele frequency distribution between patients and controls (Po0.001). By grouping alleles into 12 and non-12 CA repeats, the non-12/non-12 genotype yielded a similar significant result (Po0.001, OR ¼ 4.56, 95% CI ¼ 2.21-9.43) as observed in þ 874 A/A genotype. Weak associations of the IL-10 GCC/À genotype (P ¼ 0.04) and the low IFN-g-producing A/A genotype (P ¼ 0.06) with TB relapse/extrapulmonary cases were found. This study suggests the possible role of interferon gamma in TB susceptibility.

show abstract

Genetic association between interleukin-10 gene promoter region polymorphisms and type 1 diabetes age-at-onset

Cited by 52 publications

References 26 publications

Independent and joint effects of the IL-6 and IL-10 gene polymorphisms in pulmonary tuberculosis among the Chinese Han population

Independent and joint effects of the IL-6 and IL-10 gene polymorphisms in pulmonary tuberculosis among the Chinese Han population

Gender Susceptibility to Chronic Hepatitis C Virus Infection Associated with Interleukin 10 Promoter Polymorphism

Association of interferon gamma and interleukin 10 genes with tuberculosis in Hong Kong Chinese

Contact Info

Product

Resources

About