Genetic Association in Myocardial Infarction: Ethnicity; ABO, Rh, Lea, Xga Blood Groups; G6PD Deficiency; and Abnormal Haemoglobins

Saha, N.; Toh, C. C. S.; Ghosh, Malabika

doi:10.1136/jmg.10.4.340

Cited by 19 publications

(10 citation statements)

References 19 publications

(25 reference statements)

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“…By browsing full-text articles, we excluded 58 records because of improper or lack of comparison, other confounding factors, irrelevant to the outcomes of this study and unavailable outcomes. At last, a total of 16 articles 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 which met inclusion criteria were included into this systematic review. A flow-chart of study selection was generated according to the PRISMA requirements ( Fig.…”

Section: Resultsmentioning

confidence: 99%

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ABO blood group system and the coronary artery disease: an updated systematic review and meta-analysis

Chen

Yang

et al. 2016

Sci Rep

108

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ABO blood group system, a well-known genetic risk factor, has clinically been demonstrated to be linked with thrombotic vascular diseases. However, the relationship between ABO blood group and coronary artery disease (CAD) is still controversial. We here performed an updated meta-analysis of the related studies and tried to elucidate the potential role of ABO blood group as a risk factor for CAD. All detectable case-control and cohort studies comparing the risk of CAD in different ABO blood groups were collected for this analysis through searching PubMed, Embase, and the Cochrane Library. Ultimately, 17 studies covering 225,810 participants were included. The combined results showed that the risk of CAD was significantly higher in blood group A (OR = 1.14, 95% CI = 1.03 to 1.26, p = 0.01) and lower in blood group O (OR = 0.85, 95% CI = 0.78 to 0.94, p = 0.0008). Even when studies merely about myocardial infarction (MI) were removed, the risk of CAD was still significantly higher in blood group A (OR = 1.05, 95% CI = 1.00 to 1.10, p = 0.03) and lower in blood group O (OR = 0.89, 95% CI = 0.85 to 0.93, p < 0.00001). This updated systematic review and meta-analysis indicated that both blood group A and non-O were the risk factors of CAD.

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Section: Resultsmentioning

confidence: 99%

“…All the 17 studies were published in English from 1961 to 2014. Eleven articles 11 13 14 16 17 19 21 22 23 25 26 were case-control studies, 2 articles 12 15 were prospective cohort studies and 3 articles 18 20 24 were retrospective cohort studies. Finally, a total of 225,810 patients were included.…”

Section: Resultsmentioning

confidence: 99%

ABO blood group system and the coronary artery disease: an updated systematic review and meta-analysis

Chen

Yang

et al. 2016

Sci Rep

108

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“…S2). The key limitations to MI/angina studies were not reporting result uncertainty (12 studies) [17–28] and a lack of control for potential population stratification (12 studies) [17,22–24,26–33]. For PVD, no study reported result uncertainty and/or provided detailed demographic data [21,34–40].…”

Section: Resultsmentioning

confidence: 99%

ABO(H) blood groups and vascular disease: a systematic review and meta‐analysis

Bayoumi

Vickers

et al. 2008

Journal of Thrombosis and Haemostasis

369

329

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To cite this article: Wu O, Bayoumi N, Vickers MA, Clark P. ABO(H) blood groups and vascular disease: a systematic review and meta-analysis. 2008; 6: 62-9. Summary. Background: Associations between vascular disease and ABO(H) blood groups have a long history, but no consensus exists regarding its magnitude and significance, or whether it relates to all disorders equally. An accurate calculation of risk would allow direct assessment of whether the effects of non-O status on thrombosis risk are of the magnitude predicted by its effect on von Willebrand factor/ FVIII levels. Methods and results: We conducted a systematic review and meta-analysis of studies reporting associations with non-O blood groups. This gave pooled odds ratios of 1.25 [95% confidence interval (CI) 1.14-1.36] for myocardial infarction (MI), 1.03 (95% CI 0.89-1.19) for angina, 1.45 (95% CI 1.35-1.56) for peripheral vascular disease, 1.14 (95% CI 1.01-1.27) for cerebral ischemia of arterial origin, and 1.79 (95% CI 1.56 to 2.05) for venous thromboembolism (VTE). However, restriction to prospective MI studies only did not confirm the association (OR 1.01; 95% CI 0.84-1.23), although these studies may have failed to capture early-onset disease. For VTE, using a combined group of OO/A 2 A 2 /A 2 O as index, the combination of A 1 A 1 /A 1 B/BB gave an OR of 2.44 (95% CI 1.79-3.33) and A 1 O/ BO/A 2 B an OR of 2.11 (95% CI 1.66-2.68). Conclusions: This study confirms the historical impression of linkage between some vascular disorders and non-O blood group status. Although the odds ratios are similar to those predicted by the effect of ABO(H) on von Willebrand factor levels, further work is required to assess risk prospectively and to refine the effect of reducing O(H) antigen expression on thrombosis. However, as non-O and particularly A 1 A 1 , A 1 B, BB constitute a significant proportion of the population attributable fraction of VTE, there may be a role for more widespread adoption of ABO(H) typing in testing strategies. J Thromb Haemost

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“…A higher level of cholesterol has also been reported in association with Le(a+) [32,33]. With specific regard to Lewis groups other than Le(a−b−) , one uncontrolled study has reported a deficit of secretors (the majority of whom would be Le[b+] ) in peripheral vascular disease [34], but other studies have shown no influence of Le(a+) on either myocardial infarction [9] or ischemic stroke [10] risk.…”

Section: Discussionmentioning

confidence: 99%

The influence of maternal Lewis, Secretor and ABO(H) blood groups on fetal growth restriction

Clark

Greer

2011

Journal of Thrombosis and Haemostasis

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Summary. Background: Fetal growth restriction (FGR) is associated with thrombosis of the placenta and an increased risk of subsequent vascular disease in the mother and fetus. The products of interactions between ABO(H), Lewis and Secretor genes are also associated with thrombosis and vascular disease risk. Objectives/Methods: A prospective case–control study of mothers with a severe FGR pregnancy (cases, n = 128; controls, n = 288) was performed to determine whether FGR is associated with particular maternal blood groups. Results: No association with ABO(H) status was observed, but FGR was more common in maternal secretors (odds ratio [OR] 1.70, 95% confidence interval [CI] 1.08–2.69) and consequently in those mothers expressing Le(b) on their red cells (OR 1.80, 95% CI 1.15–2.83), with a reduced risk in non‐secretors and those expressing Le(a). Given the association between blood groups and both activated protein C resistance (APCR) and von Willebrand factor (VWF) levels, post hoc pilot studies on first‐trimester APCR and VWF antigen levels and blood group genotypes were performed. No relationship with Lewis or Secretor was observed. Despite this, lower first‐trimester VWF levels were observed in pregnancies subsequently complicated by FGR. Conclusions: This is the first study reporting a relationship between maternal Secretor/Lewis status and FGR. A link between blood groups and FGR is plausible, as both are associated with cardiovascular disease. We observed no relationship between Lewis/Secretor status and VWF or APCR, but this should be confirmed in a larger study. Thus, the mechanism whereby Secretor and/or Lewis influences FGR is unknown.

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Genetic Association in Myocardial Infarction: Ethnicity; ABO, Rh, Lea, Xga Blood Groups; G6PD Deficiency; and Abnormal Haemoglobins

Cited by 19 publications

References 19 publications

ABO blood group system and the coronary artery disease: an updated systematic review and meta-analysis

ABO blood group system and the coronary artery disease: an updated systematic review and meta-analysis

ABO(H) blood groups and vascular disease: a systematic review and meta‐analysis

The influence of maternal Lewis, Secretor and ABO(H) blood groups on fetal growth restriction

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