Genetic association of aromatic hydrocarbon receptor and its repressor gene polymorphisms with risk of rheumatoid arthritis in Han Chinese populations

Abstract

The goal of this study was to evaluate the potential relationship among polymorphisms of aromatic hydrocarbon receptor, aromatic hydrocarbon receptor repressor, and rheumatoid arthritis (RA) susceptibility as well as the association among the polymorphisms of aromatic hydrocarbon receptor, aromatic hydrocarbon receptor repressor, and their expression.We performed a hospital-based, case–control study of 400 patients with RA and 726 healthy controls in Han Chinese populations. Two single-nucleotide polymorphisms were selected for genotyping including aromatic hydrocarbon receptor (rs2066853) and aromatic hydrocarbon receptor repressor (rs2292596).To single-nucleotide polymorphism rs2292596, a statistically significantly increased risk of RA was found to be associated with the G allele of rs2292596; the odds ratio was 2.170 (95% confidence interval: 1.820–2.587). Unfortunately, no significant differences exhibited in the allelic and the genotype frequencies of rs2066853 between 2 groups. We failed to find any association between rs2066853, rs2292596 genotypes and their expression of patients, respectively. No statistical relationship was found between aromatic hydrocarbon receptor, aromatic hydrocarbon receptor repressor at messenger Ribonucleic acid levels and clinical data, either.This study demonstrated that the polymorphisms of rs2292596 was significant with genetic susceptibility to RA patients; furthermore, it suggests the G allele of rs2292596 might be associated with a dangerous effect on RA in Han Chinese populations.

The Contribution of Genetic Variation and Aberrant Methylation of Aryl Hydrocarbon Receptor Signaling Pathway Genes to Rheumatoid Arthritis

“…However, our study did not indicate a significant association of AHR rs2066853, rs2282885 polymorphism with RA susceptibility, and rs2158041 was excluded as it did not satisfy HWE. Consistent with our findings, Cheng et al demonstrated that rs2066853 polymorphism did not have any effect on RA susceptibility in Han Chinese populations ( 31 ). These results suggested that AHR gene variation might not be associated with RA, however, other functional SNPs required further investigation.…”

Chemoprevention of Colorectal Cancer by Anthocyanidins and Mitigation of Metabolic Shifts Induced by Dysbiosis of the Gut Microbiome

“…Structural work shows that AhRR acts by competitively repressing AhR binding to ARNT and target DNA (37). Furthermore, AhRR levels have been shown to decline in a variety of disease states ranging from rheumatoid arthritis (38) to lung cancer (39). Interestingly, DNA methylation at AhRR has also been shown to be a marker for smoking and was correlated with future smoking morbidity and mortality (40).…”

AHR-dependent genes and response to MTX therapy in rheumatoid arthritis patients

“…Recently, Cheng et al evaluated the potential relationship among polymorphisms of AhR and aromatic hydrocarbon receptor repressor ( AhRR ), and RA susceptibility in Han Chinese populations. It has been observed that only rs2292596 in AHRR is significantly associated with RA risk [ 21 ]. Moreover, in the literature, there is no data about this polymorphism and MTX response.…”

“…So far c.1933G > C (rs34453673) has only been mentioned in the study on CYP1A2 activity, where the association of this SNP was not proved [ 20 ]. In the case of c.565C > G (rs2292596), the association of this variant with RA risk in the Chinese Han population has been analyzed [ 21 ] and in few other studies associated with infertility [ 22 , 23 ] or xenobiotic metabolism [ 20 , 24 ].…”