Genetic association of FTO/IRX region with obesity and overweight in the Polish population

Sobalska‐Kwapis, Marta; Suchanecka, Aleksandra; Słomka, Marcin; Siewierska-Górska, Anna; Kępka, Ewa; Strapagiel, Dominik

doi:10.1371/journal.pone.0180295

Cited by 24 publications

(56 citation statements)

References 60 publications

(63 reference statements)

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“…The outcomes of our study and the one of and Sobalska-Kwapis et al suggest that in Polish women, obesity is less influenced by FTO polymorphism than in men. 26 To further explore this problem, we analyzed the FTO influence on obesity in female subgroups according to menopausal status and age, but it did not change our results. There are suggestions that the association between FTO gene and obesity is age-dependent.…”

Section: Discussionmentioning

confidence: 94%

“…It has been also revealed in this study that obesity-associated SNPs had a different inheritance model in men (recessive) than in women (dominant). 26 In the Mexican population, Saldaña-Alvarez et al have shown, in turn, that 2 FTO SNPs were specifically associated in men under a dominant model, while 3 were associated with women under additive and recessive models. 31 Together with our results, this highlights the need to consider sex as an important factor modulating FTO genetic association with overweight and obesity.…”

Section: Discussionmentioning

confidence: 99%

“…These SNPs are located in intron 1 and stay in almost complete linkage disequilibrium (LD) (|D'| > 0.98, r 2 > 0.80). 26 Many studies confirmed that the FTO gene variation predisposes to excessive weight. This association varies significantly in different ethnic groups.…”

Section: Discussionmentioning

confidence: 99%

“…25 A recent association analysis in Poland confirmed the correlation between susceptibility loci in intron 1 of the FTO gene with obesity; however, it did not include the aspect of cardiovascular complications. 26 Other studies conducted in Poland were based on smaller sample sizes 13,27 or included only specific groups, like children with diabetes 28 or women with polycystic ovary syndrome (PCOS). 29 We examined the largest number of subjects from an unselected Polish population for the FTO variation and metabolic syndrome components.…”

Section: Introductionmentioning

confidence: 99%

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The association between FTO gene polymorphism rs9939609 and obesity is sex-specific in the population of PURE study in Poland

Zdrojowy-Wełna¹,

Bednarek-Tupikowska²,

Zatońska³

et al. 2020

Adv Clin Exp Med

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The association between FTO gene polymorphism rs9939609 and obesity is sex-specific in the population of PURE study in Poland Abstract Background. Fat mass and obesity-associated gene (FTO) polymorphism remains the strongest known genetic determinant of common obesity. However, its influence depends on ethnicity, and the FTO-mediated predisposition to other metabolic disturbances is questionable.Objectives. The aim of our study was to evaluate the association between FTO rs9939609 polymorphism and metabolic syndrome in a population of Prospective Urban Rural Epidemiology (PURE) study in Poland.Material and methods. We enrolled 1,097 participants of the PURE study (683 women and 414 men) from the Lower Silesian voivodeship. Anthropometrical parameters and blood pressure were measured. Blood samples were taken for an examination of lipid profile and fasting glucose level. Genomic DNA was isolated and FTO polymorphism rs9939609 was genotyped.Results. Male A-allele carriers had significantly higher mean body mass, body mass index (BMI), waistto-hip ratio (WHR), and waist and hip circumferences than men without risk allele. They were also more often diagnosed with obesity on the basis of BMI and central obesity parameters. No such influence was observed in women. There were no significant associations between FTO polymorphism and metabolic syndrome or its components. Conclusions.Our results suggest a sex-specific association between FTO polymorphism and obesity traits. The occurrence of metabolic syndrome or its components was not related with FTO gene variation in our cohort.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The association between FTO gene polymorphism rs9939609 and obesity is sex-specific in the population of PURE study in Poland

Zdrojowy-Wełna¹,

Bednarek-Tupikowska²,

Zatońska³

et al. 2020

Adv Clin Exp Med

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“…FTO SNPs were associated with obesity among females only when assuming a dominant inheritance model, whereas among males when assuming a recessive inheritance model. A strong association of FTO intronic variants with overweight was revealed only in men, suggesting that overweight might be regulated by a different genetic manner dependent on sex, and probably controlled by other genomic region(s) in females (Sobalska‐Kwapis et al, ).…”

Section: Discussionmentioning

confidence: 99%

Genetic variation of FTO: rs1421085 T>C, rs8057044 G>A, rs9939609 T>A, and copy number (CNV) in Mexican Mayan school‐aged children with obesity/overweight and with normal weight

González-Herrera

Zavala-Castro

Ayala-Cáceres

et al. 2018

American J Hum Biol

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Objectives Genetic variation of the fat mass and obesity associated gene (FTO) has been identified as a risk factor for obesity and obesity traits. Distribution of FTO single nutleotide polymorphisms (SNPs) rs1421085T>C, rs9939609T>A, rs8057044G>A and copy number variation (CNV) was evaluated in association with childhood obesity or overweight status in children with Mayan ethnicity. Methods We included 318 school‐aged children with obesity or overweight status (body mass index [BMI]: >85th percentile) and 303 children with normal weight (BMI: 15th‐85th percentile). Genotyping was performed using real‐time polymerase chain reaction (RT‐PCR) with TaqMan probes. The cross‐sectional study was carried out using univariate and multivariate logistic regression models adjusted for gender. Results FTO‐SNP rs1421085 showed significant differences between children with obesity and children with normal weight for the heterozygous genotype (P = 0.003) and for allele frequencies (P = 0.023). Adjusting by gender, significant differences were found in frequencies of the hetezygous genotype of SNPs rs9939609 (P = 0.023) and rs1421085 (P = 0.003) as well as in allele frequencies (P = 0.042 and P = 0.013, respectively) between girls with obesity and girls without obesity. In contrast, SNP rs8057044 was significantly different only between heterozygous overweight versus normal weight boys (P = 0.035) and for the allele frequency of rs8057044 (P = 0.021). The mean relative CNV was significantly higher in male overweight children than in boys with normal weight (P = 0.000). Conclusions The FTO SNP rs1421085 is a genetic factor associated with obesity in Mayan school‐aged children. FTO SNPs rs1421085 and rs9939609 affect genetic susceptibility for obesity only in girls, whereas, SNP rs8057044 and CNV are associated with overweight status only in boys.

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A novel association of rs13334070 in the RPGRIP1L gene with adiposity factors discovered by joint linkage and linkage disequilibrium analysis in Iranian pedigrees: Tehran Cardiometabolic Genetic Study (TCGS)

Javanrouh

Soltanian

Tapak

et al. 2018

Genetic Epidemiology

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Understanding the genetic and metabolic bases of obesity is helpful in planning and developing health strategies. Therefore, the first family‐based joint linkage and linkage disequilibrium study was conducted in Iranian pedigrees to assess the relationship between obesity and single‐nucleotide polymorphisms (SNPs) located in the 16q12.2 region. In the present study, a total of 13,344 individuals were included, of whom 12,502 individuals were within 3,109 pedigrees and 842 were unrelated singletons. To investigate the relationship between obesity and genetic variants, a joint model of linkage and linkage disequilibrium was applied. Moreover, a sequence kernel association test (SKAT) was used to evaluate the association of the SNP set with body size and lipid profile measurements. The joint model showed that rs13334070, in the intron 4 of the RPGRIP1L gene, has a significant association with obesity. According to the 4‐gamete rule, which is a procedure for constructing SNP sets by considering recombination occurrence between SNPs, this polymorphism has a high correlation with six nearby SNPs that make an SNP set. SKAT showed that this SNP set has a significant association with body size factors, but almost no association with most of the lipid profile measurements. In conclusion, from the result of this study, it might be reasonable to consider RPGRIP1L as an important gene whose variations could be associated with obesity risk factors.

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Genetic association of FTO/IRX region with obesity and overweight in the Polish population

Cited by 24 publications

References 60 publications

The association between FTO gene polymorphism rs9939609 and obesity is sex-specific in the population of PURE study in Poland

The association between FTO gene polymorphism rs9939609 and obesity is sex-specific in the population of PURE study in Poland

Genetic variation of FTO: rs1421085 T>C, rs8057044 G>A, rs9939609 T>A, and copy number (CNV) in Mexican Mayan school‐aged children with obesity/overweight and with normal weight

A novel association of rs13334070 in the RPGRIP1L gene with adiposity factors discovered by joint linkage and linkage disequilibrium analysis in Iranian pedigrees: Tehran Cardiometabolic Genetic Study (TCGS)

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