Genetic association of phase I and phase II detoxification genes with recurrent miscarriages among North Indian women

Parveen, Farah; Faridi, Rehan M.; Das, Vinita; Tripathi, Gaurav; Agrawal, Suraksha

doi:10.1093/molehr/gap096

Cited by 35 publications

(29 citation statements)

References 40 publications

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“…After the full-text evaluation, five articles were excluded with reasons for no available data (n = 1) [11], irrelevance to endometriosis (n = 1) [12], duplicate publications (n = 3) [13][14][15]. An article providing data for two different subgroups (Caucasian and Asian) was counted as two separate studies [6].…”

Section: Literature Search and Study Selectionmentioning

confidence: 99%

The cytochrome P4501A1 gene polymorphisms and endometriosis: a meta-analysis

Fan

Huang

Xiao

et al. 2016

J Assist Reprod Genet

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Purpose Cytochrome P450 1A1 (CYP1A1) polymorphisms were implicated in endometriosis risk, but individual published studies showed inconclusive results. Thus, a metaanalysis was performed to clarify the effect of CYP1A1 polymorphisms on endometriosis risk. Methods PubMed, Embase, and CNKI databases were searched to identify the eligible studies focusing on the associations between CYP1A1 MspI and Ile462Val polymorphisms and susceptibility to endometriosis. Summary odds ratios (ORs) and 95 % confidence intervals (95 % CIs) for CYP1A1 polymorphisms and endometriosis were calculated. Results Pooled analysis of 12 studies involved a total of 1555 cases and 2868 controls showed that in all genetic models, no significant association between CYP1A1 MspI polymorphism and endometriosis risk was observed in the overall, Asians and Caucasians population, respectively. Interestingly, increased endometriosis risk was associated with carrying the C allele of CYP1A1 combined with GSTM1 null genotypes. For CYP1A1 Ile462Val polymorphism, eight studies were available (878 cases and 1991 controls). In the overall analysis, CYP1A1 Ile462Val polymorphism had a statistically significant association with increased endometriosis risk in allele contrast and all genetic models except the model of Val/Ile vs. Ile/Ile. In the subgroup analysis by ethnicity, significant elevated endometriosis risk was associated with CYP1A1 Ile462Val polymorphism in Asians but not in Caucasians under all genetic models. No publication bias was found in the present studies. Conclusions This meta-analysis suggested that CYP1A1 Ile462Val polymorphism was associated with an increased risk of endometriosis, particularly in Asians. CYP1A1 MspI polymorphism may not be associated with endometriosis risk, but GSTM1 and CYP1A1 MspI polymorphism may have a joint effect on endometriosis risk.

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Section: Literature Search and Study Selectionmentioning

confidence: 99%

The cytochrome P4501A1 gene polymorphisms and endometriosis: a meta-analysis

Fan

Huang

Xiao

et al. 2016

J Assist Reprod Genet

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“…This suggests that GSTP1 may be the most important GST in the pathogenesis of endometrial hyperplasia. For this reason, several studies have been conducted to evaluate the association of GSTP1-313 A > G polymorphism with endometrial carcinoma risk [15][16][17][18][19][20][21][22], but there were no previous results evaluating the association between this polymorphism and endometrial hyperplasia. Therefore, the aim of our study is to derive a more precise estimation of the association between GSTP1-313 A > G (Ile105Val) polymorphism and EH susceptibility among Egyptian women.…”

Section: Introductionmentioning

confidence: 99%

Association of glutathione-S-transferase P1 (GSTP1)-313 A>G gene polymorphism and susceptibility to endometrial hyperplasia among Egyptian women

Elsaid

Al-Kholy

Ramadan

et al. 2015

Egyptian Journal of Medical Human Genetics

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Background: Endometrial hyperplasia (EH) occurs when the endometrium, the lining of the uterus, becomes too thick, causing abnormal uterine bleeding. In some cases, it can lead to endometrial carcinoma if untreated. Glutathione-S-transferases (GSTs) enzymes have a role in the metabolism of a lot of disease-causing carcinogens and mutagens that are present in environments of human. GSTP1-313 A > G gene polymorphism was associated with significantly high risk of endometrial carcinoma in some reports. The aim of this work is to assess the association of this polymorphism with the susceptibility of EH among a sample of Egyptian women.Subjects and methods: This study included 84 unrelated EH Egyptian women who were compared to 134 healthy controls from the same locality. For all subjects, DNA was genotyped for GSTP1-313 A > G (Ile105Val) polymorphism using the PCR-RFLP technique.Results: The frequency of GSTP1-313 AG and GG genotypes was noted to be significantly higher among most of the cases with EH compared to controls (79.8% vs. 42.0%, OR = 8.63, 95% CI = 4.53-16.46, p < 0.001). Also the frequency of the GSTP1-313 G allele was significantly higher among most of the cases compared to controls (24.9% vs. 16.8%, OR = 3.72, 95% CI = 2.39-5.79, p < 0.001). Furthermore, there was a significant increase of endometrial thickness in the EH women compared to controls (p < 0.001).Conclusions: GSTP1-313 G allele carriage was associated with susceptibility of EH among a sample of Egyptian women.

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“…GSTs are divided into three families: cytosolic, mitochondrial, and the membrane-associated proteins in eicosanoid and glutathione metabolism proteins, among them, the cytosolic subfamily is by far the most abundant one [7]. Numbers of studies have suggested that the genetic polymorphism of cytosolic GST genes was associated with the risk of RSA [8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Glutathione S-transferase A1 polymorphism and the risk of recurrent spontaneous abortion in Chinese Han population

Zong

Sha

Xiang

et al. 2014

J Assist Reprod Genet

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Objective Recurrent spontaneous abortion (RSA) is a multifactor and distressing disease. There are still approximately half of the RSA patients with cause not being identified to date. Accumulating studies have confirmed that genetic polymorphisms in glutathione S-transferases (GSTs) were associated with the risk of recurrent spontaneous abortion. In this study, we aimed to investigate the relationship between the polymorphism of GSTA1, which is GSTA1 -69C/T (rs3957357), and the development of recurrent spontaneous abortion.Methods A case-control study of 127 cases with RSA and 112 ethnic and age matched women as controls was conducted. And measurement of Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) was performed to genotype all of samples in order to analyze the association between GSTA1 -69C/T (rs3957357) and the risk of RSA. Results We found that the frequencies of genotypes between cases and controls have no significant difference (P=0.908) and GSTA1 mutant allele GSTA1 −69 T was present at a frequency of 0.122 in case group, while in controls the frequency was 0.125 (P=0.922). Conclusion The polymorphism of GSTA1 (rs3957357) may not be associated with the risk of recurrent spontaneous abortion in Chinese Han population.

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Genetic association of phase I and phase II detoxification genes with recurrent miscarriages among North Indian women

Cited by 35 publications

References 40 publications

The cytochrome P4501A1 gene polymorphisms and endometriosis: a meta-analysis

The cytochrome P4501A1 gene polymorphisms and endometriosis: a meta-analysis

Association of glutathione-S-transferase P1 (GSTP1)-313 A>G gene polymorphism and susceptibility to endometrial hyperplasia among Egyptian women

Glutathione S-transferase A1 polymorphism and the risk of recurrent spontaneous abortion in Chinese Han population

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