Genetic association of preeclampsia to the inflammatory response gene SEPS1

Selenoprotein S expression in reactive astrocytes following brain injury

“…Single nucleotide polymorphisms in SelS promoter impair SelS expression and prompt a basal pro-inflammatory state in humans that is characterized by increased release of inflammatory cytokines (Curran et al, 2005). Variations in SelS promoter sequence have also been associated to higher susceptibility to diseases linked to inflammation such as ischemic stroke, coronary heart disease, preeclampsia, and gastric cancer (Alanne et al, 2007;Moses et al, 2008;Shibata et al, 2009). SelS link to inflammation is confirmed by in vitro studies showing that SelS regulates the production of inflammatory cytokines (Curran et al, 2005;Gao et al, 2006).…”

Maternal selenium status during early gestation and risk for preterm birth

“…[6][7][8] A polymorphism in the gene encoding the selenoprotein SEPS1 has been shown to affect the risk of preeclampsia, a condition that has a strong inflammatory component that is an important cause of preterm birth. 8 In addition, low selenium status has been identified in women with preeclampsia. 12 We hypothesized that low maternal selenium status (as measured by low serum selenium concentration early in gestation would be associated with preterm birth.…”

“…26 Previous studies have described the various roles that selenium plays in attenuating the excessive inflammatory response associated with adverse pregnancy outcomes. 7,8,[27][28][29][30][31][32] The selenoprotein, thioredoxin reductase, contributes to the upregulation of heme oxygenase -1 during inflammation and periods of oxidative stress. [33][34][35][36] Heme oxygenase-1 and its products (carbon monoxide, biliverdin and ferrous ions [Fe 2+ ]) are vitally important for successful placentation, maintenance of uterine quiescence, regulation of hemodynamic control within the uterus and placenta, protection against ischemiareperfusion injury, protection against pre eclampsia, regulation of the apoptotic and inflammatory cascades in trophoblast cells and for increased vasodilatory (carbon monoxide), anti -inflammatory (bilirubin and carbon monoxide), and antioxidant (biliverdin and bilirubin) effects.…”

“…4,5 The trace mineral selenium, available from food (though to a greater or lesser extent according to region), can interact with a number of these risk factors. [6][7][8][9] It has been implicated in pregnancy outcome, [9][10][11][12] and it plays a role in the immune response and the body's resistance to infection. 6 Enzymes containing the mineral, selenoenzymes, can attenuate the excessive Methods: White Dutch women with a singleton pregnancy (n = 1197) were followed prospectively from 12 weeks' gestation.…”

Molekulare Medizin in der Geburtshilfe

“…Es gibt einige Gene, die mit der Präeklampsie-Entstehung in Verbindung gebracht werden: eine Angiotensinogen-Genvariante (T235), das endotheliale NO-Synthase-Gen (eNOS) sowie Thrombophilie-verursachende Gene [10]. Kürzlich wurde der genetische Polymorphismus des Selenprotein-S-Gens (SEPS1) beschrieben, der mit den zirkulierenden Spiegeln des TNFα, des IL-6 und des IL-1β und in einer Norwegischen Populationsstudie deutliche Korrelationen zur Präeklampsie zeigte [13].…”