Genetic Association of rs1800780 (A→G) Polymorphism of the eNOS Gene with Susceptibility to Essential Hypertension in a Chinese Han Population

Abstract

To investigate the association of eNOS gene polymorphism with essential hypertension in the Chinese Han population, we examined polymorphisms of the rs2070744 (T→C), rs1800780 (A→G), and rs3918181 (A→G) loci. The results demonstrated that the genotypic frequency at the rs1800780 (A→G) locus was significantly different between patients with essential hypertension and the control cohorts (P < 0.05); while genotypic frequencies and allelic frequencies at rs2070744 (T→C) and rs3918181 (A→G) loci had no statistical difference between the patient group and controls (P > 0.05). In addition, haplotype analysis found a statistically significant difference for haplotype TGA, with OR (95% CI) of 1.549 (1.116-2.150) (P < 0.05). These findings suggest that polymorphism of rs1800780 (A→G) in the eNOS gene may be one of the most important genetic factors associated with essential hypertension susceptibility, and those who have haplotype TGA may be at risk to develop essential hypertension.

Premature presbyopia: causes, diagnosis, and management strategies - an overview

“…condition. 4 Environmental factors such as prolonged near work, excessive screen time, and exposure to ultraviolet radiation may also contribute to the development of premature presbyopia. 5 Additionally, ocular conditions such as high myopia, astigmatism, and certain corneal abnormalities have been implicated in accelerating the onset of presbyopia symptoms.…”

“…Genetic predisposition plays a significant role, with studies identifying candidate genes associated with early-onset presbyopia. 4 Additionally, ocular conditions such as high myopia, astigmatism, and certain corneal abnormalities have been implicated in premature presbyopia. 3 Environmental factors such as prolonged near work, excessive screen time, and exposure to ultraviolet radiation may accelerate the onset of presbyopia symptoms.…”

Apelin/APJ system: a promising therapy target for hypertension

“…Many studies have revealed hypertension significant contact with certain genetic polymorphisms.The present researches considered that hypertension pathogenic genes may be associated with RAAS, vasopressin receptor gene, ET-1 and eNOS, etc. [75][76][77]. Recently, apelin and AGTRL1 genetic polymorphisms might contribute to essential hypertension or its related phenotypes has been raised.…”

Патогенетичне Значення Апеліну В Розвитку Артеріальної Гіпертензії

“…АГ є поліпатогенетичним, мультифакторіальним захворюванням, у розвитку якого певну роль відіграють генетичні чинники. У ряді досліджень показано, що етіопатогенез АГ пов'язаний зі змінами в генах РАС, рецепторах до вазопресину, ендотеліну-1 та продукції NO [13,49,53]. Разом із тим у деяких працях вказується на зв'язок різних типів поліморфізму генів апеліну та APJ-рецептора з гіпертензією, що дозволяє розглядати їх як потенційні гени-кандидати розвитку АГ [30,59].…”