Genetic association of rs564398 polymorphism of the ANRIL long non-coding RNA gene and risk of type 2 diabetes: A meta-analysis

Ammar, Muhammad; Lipovich, Leonard; Шкурат, Т. П.; Ali, R.M.

doi:10.1016/j.mgene.2021.100997

Cited by 3 publications

(1 citation statement)

References 29 publications

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“…By interacting with polycomb repressive complex 1 (PRC-1) and PRC-2, it epigenetically silences other genes within the cluster. ANRIL has been reported frequently as a genomic susceptibility locus for cardiovascular disease (CVD), 57,58 Alzheimer's disease, 59 and type 2 diabetes, 57,60,61 as well as open-angle glaucoma (OAG) blindness, 62,63 breast cancer, 64 and glioma 65 by genome-wide association studies (GWAS). It is a recurrent hotspot in GWAS.…”

Section: Context Of Study In Vivo and In Vitro Studiesmentioning

confidence: 99%

Emerging roles of long non‐coding RNAs in human epilepsy

Yazarlou,

Lipovich,

Loeb

2024

Epilepsia

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Genome‐scale biological studies conducted in the post‐genomic era have revealed that two‐thirds of human genes do not encode proteins. Most functional non‐coding RNA transcripts in humans are products of long non‐coding RNA (lncRNA) genes, an abundant but still poorly understood class of human genes. As a result of their fundamental and multitasking regulatory roles, lncRNAs are associated with a wide range of human diseases, including neurological disorders. Approximately 40% of lncRNAs are specifically expressed in the brain, and many of them exhibit distinct spatiotemporal patterns of expression. Comparative genomics approaches have determined that 65%–75% of human lncRNA genes are primate‐specific and hence can be posited as a contributing potential cause of the higher‐order complexity of primates, including human, brains relative to those of other mammals. Although lncRNAs present important mechanistic examples of epileptogenic functions, the human/primate specificity of lncRNAs questions their relevance in rodent models. Here, we present an in‐depth review that supports the contention that human lncRNAs are direct contributors to the etiology and pathogenesis of human epilepsy, as a means to accelerate the integration of lncRNAs into clinical practice as potential diagnostic biomarkers and therapeutic targets. Meta‐analytically, the major finding of our review is the commonality of lncRNAs in epilepsy and cancer pathogenesis through mitogen‐activated protein kinase (MAPK)‐related pathways. In addition, neuroinflammation may be a relevant part of the common pathophysiology of cancer and epilepsy. LncRNAs affect neuroinflammation‐related signaling pathways such as nuclear factor kappa‐ light‐ chain‐ enhancer of activated B cells (NF‐κB), Notch, and phosphatidylinositol 3‐ kinase/ protein kinase B (Akt) (PI3K/AKT), with the NF‐κB pathway being the most common. Besides the controversy over lncRNA research in non‐primate models, whether neuroinflammation is triggered by injury and/or central nervous system (CNS) toxicity during epilepsy modeling in animals or is a direct consequence of epilepsy pathophysiology needs to be considered meticulously in future studies.

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Section: Context Of Study In Vivo and In Vitro Studiesmentioning

confidence: 99%

Emerging roles of long non‐coding RNAs in human epilepsy

Yazarlou,

Lipovich,

Loeb

2024

Epilepsia

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Genetic variants of ANRIL and coronary artery disease: Insights from a Turkish study population

Ozuynuk-Ertugrul,

Kirsan,

Erkan

et al. 2024

Gene

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Polymorphism rs564398 of the ANRIL Gene as a Coronary-Artery-Disease-Associated SNP in Diabetic Patients of the Kazakh Population

Aitkaliyev,

Bekenova,

Vochshenkova

et al. 2024

Diagnostics

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Background/Objectives. A cardiovascular complication of type 2 diabetes mellitus like coronary artery disease is influenced by a complex interplay between environmental, phenotypic, and genetic factors. The genetic mechanisms in the development of this pathology are not established. This study aims to evaluate the association of polymorphisms rs1011970, rs62560775, and rs564398 from the 9p21.3 locus with coronary artery disease in diabetic patients of the Kazakh population. Methods. A total of 343 people participated in the case-control study: the control group consisted of 109 people with type 2 diabetes and coronary artery disease, while the control group included 234 people. Genotyping was performed using real-time PCR. Statistical analysis was carried out using Chi-square methods and calculating odds ratios (OR) with 95% confidence intervals (CI). Results. According to the results, only the rs564398 polymorphism of the ANRIL gene was associated with coronary artery disease (p = 0.04). The CC genotype increased the risk of developing coronary artery disease by more than 1.5 times (1.62 (1.02–2.56)), whereas the TT genotype reduced the risk of coronary artery disease (0.39 (0.17–0.91)). The remaining polymorphisms, rs1011970 and rs62560775, were not associated with coronary artery disease. Conclusions. Thus, this research further elicits the association of the ANRIL gene with cardiometabolic disease.

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Genetic association of rs564398 polymorphism of the ANRIL long non-coding RNA gene and risk of type 2 diabetes: A meta-analysis

Cited by 3 publications

References 29 publications

Emerging roles of long non‐coding RNAs in human epilepsy

Emerging roles of long non‐coding RNAs in human epilepsy

Genetic variants of ANRIL and coronary artery disease: Insights from a Turkish study population

Polymorphism rs564398 of the ANRIL Gene as a Coronary-Artery-Disease-Associated SNP in Diabetic Patients of the Kazakh Population

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