Genetic Association of Short Sleep Duration With Hypertension Incidence

Kim, Sejoong; Lee, Seung Ku; Kim, Seong Hwan; Yun, Chang-Ho; Kim, Je Hyeong; Thomas, Robert J.; Shin, Chol

doi:10.1253/circj.cj-11-0713

Cited by 34 publications

(23 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A recent meta-analysis 27 assessed the association between sleep duration and the risk of hypertension using literature research updated on 28 October 2011. However, to our knowledge, two prospective cohort studies on the association between sleep duration and hypertension have been published since then; 24, 28 furthermore, no meta-analysis has yet been conducted to address the association between insomnia and hypertension incidence. Therefore, the goal of the present meta-analysis was to quantitatively estimate whether sleep duration or insomnia increase the risk of hypertension incidence, using the most recent data.…”

Section: Introductionmentioning

confidence: 99%

The relationship of sleep duration and insomnia to risk of hypertension incidence: a meta-analysis of prospective cohort studies

2013

View full text Add to dashboard Cite

To assess whether habitual sleep duration or insomnia increase the incidence of hypertension. PubMed, EMBASE and Cochrane were searched without language restriction. Prospective cohort studies of adults with at least a 1-year follow-up duration were included. Habitual sleep duration or symptoms of insomnia were assessed as baseline exposure, and the outcome was incidence of hypertension. Subgroup, meta-regression and sensitivity analyses were conducted to assess heterogeneity, and Egger's test was used to assess publication bias. Eleven studies (17 cohorts) were included. Short sleep duration, sleep continuity disturbance (SCD), early-morning awakening (EMA) and combined symptoms of insomnia increased the risk of hypertension incidence (the relative risks (95% confidence intervals) were 1.21 (1.05–1.40) for short sleep duration, 1.20 (1.06–1.36) for SCD, 1.14 (1.07–1.20) for EMA and 1.05 (1.01–1.08) for combined insomnia symptoms). Less evidence exists to support conclusions about the association between long sleep duration or difficulty falling asleep (DFA) and hypertension incidence. No obvious heterogeneity or publication biases were found. Our meta-analysis demonstrates that short sleep duration and single/combined symptoms of insomnia (except DFA) are associated with an increased risk of hypertension incidence. It is important to consider sleep duration and insomnia during hypertension prevention and treatment. More laboratory studies on potential mechanisms and prospective observational studies with objective measures of sleep are needed.

show abstract

Section: Introductionmentioning

confidence: 99%

The relationship of sleep duration and insomnia to risk of hypertension incidence: a meta-analysis of prospective cohort studies

2013

View full text Add to dashboard Cite

show abstract

“…Cellular transporters are present within several phenotypes, and of particular note, they span 3 distinct molecular motor protein subfamilies: KIF1B (kinesin; DBP slope); DNAH14 (dynein; SBP slope), DNAH17, and DNAH9 (dynein; 5 phenotype intersection); and MYO1D (myosin; 5 phenotype intersection). MYO1D has been associated with hypertension [18], and phosphorylation of the myosin light chain, mediated by Ca +2 , is necessary for the regulation of vascular small muscle contraction [19]. VAV3 was identified in both the DBP slope and SBP slope phenotypes as noted above.…”

Section: Resultsmentioning

confidence: 97%

Integrated statistical and pathway approach to next-generation sequencing analysis: a family-based study of hypertension

et al. 2014

View full text Add to dashboard Cite

Genome wide association studies (GWAS) have been used to search for associations between genetic variants and a phenotypic trait of interest. New technologies, such as next-generation sequencing, hold the potential to revolutionize GWAS. However, millions of polymorphisms are identified with next-generation sequencing technology. Consequently, researchers must be careful when performing such a large number of statistical tests, and corrections are typically made to account for multiple testing. Additionally, for typical GWAS, the p value cutoff is set quite low (approximately <10−8). As a result of this p value stringency, it is likely that there are many true associations that do not meet this threshold. To account for this we have incorporated a priori biological knowledge to help identify true associations that may not have reached statistical significance. We propose the application of a pipelined series of statistical and bioinformatic methods, to enable the assessment of the association of genetic polymorphisms with a disease phenotype--here, hypertension--as well as the identification of statistically significant pathways of genes that may play a role in the disease process.

show abstract

“…There have been several studies that examined the relationship between single nucleotide polymorphism (SNP) and blood pressure or hypertension via genome-wide association studies (GWAS) among Koreans [4,5,6,7,8,9,10,11,12]. However, the mechanism of blood pressure is not sufficiently explained by the genetic effect.…”

Section: Introductionmentioning

confidence: 99%

Interaction between Single Nucleotide Polymorphism and Urinary Sodium, Potassium, and Sodium-Potassium Ratio on the Risk of Hypertension in Korean Adults

et al. 2017

View full text Add to dashboard Cite

Hypertension is a complex disease explained with diverse factors including environmental factors and genetic factors. The objectives of this study were to determine the interaction effects between gene variants and 24 h estimated urinary sodium and potassium excretion and sodium-potassium excretion ratios on the risk of hypertension. A total of 8839 participants were included in the genome-wide association study (GWAS) to find genetic factors associated with hypertension. Tanaka and Kawasaki formulas were applied to estimate 24 h urinary sodium and potassium excretion. A total of 4414 participants were included in interaction analyses to identify the interaction effects of gene variants according to 24 h estimated urinary factors on the risk of hypertension. CSK rs1378942 and CSK-MIR4513 rs3784789 were significantly modified by urinary sodium-potassium excretion ratio. In addition, MKLN rs1643270 with urinary potassium excretion, LOC101929750 rs7554672 with urinary sodium and potassium excretion, and TENM4 rs10466739 with urinary sodium-potassium excretion ratio showed significant interaction effects. The present study results indicated that the mutant alleles of CSK rs1378942 and CSK-MIR4513 rs3784789 had the strongest protective effects against hypertension in the middle group of 24 h estimated urinary sodium-potassium excretion ratio. Further studies are needed to replicate these analyses in other populations.

show abstract

Genetic Association of Short Sleep Duration With Hypertension Incidence

Cited by 34 publications

References 45 publications

The relationship of sleep duration and insomnia to risk of hypertension incidence: a meta-analysis of prospective cohort studies

The relationship of sleep duration and insomnia to risk of hypertension incidence: a meta-analysis of prospective cohort studies

Integrated statistical and pathway approach to next-generation sequencing analysis: a family-based study of hypertension

Interaction between Single Nucleotide Polymorphism and Urinary Sodium, Potassium, and Sodium-Potassium Ratio on the Risk of Hypertension in Korean Adults

Contact Info

Product

Resources

About