Genetic association of Tumour necrosis factor alpha, Interleukin-18 and Interleukin 1 beta with the risk of coronary artery disease: A case-control study outcome from Kashmir

Khan, Nilofer; Allai, Mohammad Sultan; Nissar, Bushra; Naykoo, Niyaz A.; Hameed, Iqra; Majid, Misbah; Bhat, Aaliya; Afshan, Falaque Ul; Ganai, Bashir Ahmad

doi:10.1016/j.jab.2018.02.004

Cited by 6 publications

(4 citation statements)

References 59 publications

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“…отметили высокий риск развития ИБС в доминантной модели GG против GA+AA полиморфизма rs1800629 гена TNF (ОШ 0,43; 95% ДИ 0,23-0,82; p=0,0099) у населения Кашмира. Частота генотипов GA и AA была выше у лиц без сахарного диабета (ОШ 3,52; 95% ДИ 1,54-8,07; р=0,0019) [24].…”

Section: ассоциация полиморфизма Rs1800629 гена Tnf с ибсunclassified

Tumor necrosis factor gene polymorphism rs1800629 in patients with atherosclerotic cardiovascular diseases: A review

Khazova,

Bulashova,

Valeeva

2023

Consilium Medicum

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The close attention of researchers is riveted to the study of socially significant multifactorial diseases and syndromes with a hereditary predisposition, which include chronic heart failure, formed as a result of atherosclerosis of the coronary arteries. The promise of genomic studies in atherosclerosis and heart failure is associated with the possibility of determining the genetic risk of developing and predicting adverse cardiovascular events before the onset of clinical signs/symptoms. From the standpoint of understanding the pathogenesis of atherosclerosis as a variant of nonspecific inflammation, which has a wave-like character, it is assumed that genes encoding pro-inflammatory cytokines influence the pathological process. The aim of the review was to analyze the results of studies available in available publications on the rs1800629 polymorphism of the tumor necrosis factor (TNF) gene in patients with atherosclerotic cardiovascular diseases. Most data indicate the presence of an increased cardiovascular risk in carriers of the A allele of the rs1800629 polymorphism of the TNF gene. It was determined that carriage of the AA genotype is associated with essential arterial hypertension and remodeling of the left ventricular myocardium. In patients with chronic heart failure with preserved and moderately reduced left ventricular ejection fraction of the AA genotype, low blood pressure and frequent occurrence of atrial fibrillation were noted. A number of papers present the results of studies of the rs1800629 polymorphism of the TNF gene and the prognostic significance of the rs1800629 polymorphism of the TNF gene in heart failure.

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Section: ассоциация полиморфизма Rs1800629 гена Tnf с ибсunclassified

Tumor necrosis factor gene polymorphism rs1800629 in patients with atherosclerotic cardiovascular diseases: A review

Khazova,

Bulashova,

Valeeva

2023

Consilium Medicum

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“…В сверхдоминантной модели (СТ и СС+ТТ) не наблюдалось существенного отличия (ОR=1,68; 95% ДИ: 0,83-3,41; р=0,15). При ИБС с отягощенным по кардиальным заболеваниям анамнезом чаще наблюдался СТ-генотип (ОR=0,32; 95% ДИ: 0,10-0,99, р=0,029) [20].…”

Section: Review Interleukin-1в Gene Rs1143634 Polymorphism and Cardio...unclassified

Interleukin-1β gene rs1143634 polymorphism and cardiovascular complications in patients with coronary artery atherosclerosis

Khazova,

Bulashova,

Valeeva

2023

Evrazijskij kardiologičeskij žurnal

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The course of heart failure, regardless of its etiology, is associated with local and systemic activation of inflammatory signaling cascades. Identification of the association of candidate cytokine genes with the risk of developing coronary heart disease and chronic heart failure remains a subject of interest for many researchers. The review presents an analysis of studies of the rs1143634 polymorphism of the IL-β gene in relation to the risk of atherosclerotic cardiovascular complications. The presence of the minor allele T is associated with an increase in the concentration of IL-1β in the blood serum. Data on the role of the rs1143634 polymorphism of the IL-β gene in atherosclerotic coronary heart disease, including in combination with chronic heart failure syndrome, are presented, taking into account ethnic characteristics and gender of patients. The carriage of the T allele was associated with the risk of developing atherosclerosis and myocardial infarction. At the same time, it is reported that the C allele and the CC genotype of the rs1143634 polymorphism of the IL-1β gene were a genetic risk factor for the development and progression of heart failure. In a number of studies and meta-analyses, the association of this polymorphism with diseases of the cardiovascular system was not confirmed, but certain trajectories of the risk of complications were identified due to differences in the rs1143634 polymorphism of the IL-β gene in heart failure.

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“…16 However, it was recently shown to be associated with increased coronary artery disease risk in a Kashmiri population. 17 It was associated with higher levels of very lowdensity lipoprotein (VLDL) cholesterol and triglycerides in Colombians, as well as with higher levels of fasting glucose, suggesting it is involved in lipid and glycemic responses. This variant was also associated with greater abundance of an OTU classified as Ruminococcus bromii (Ruminococcaceae), a primary degrader of resistant starch 18 and a major producer of colonic butyrate.…”

Section: Innate Immunitymentioning

confidence: 99%

Variants in genes of innate immunity, appetite control and energy metabolism are associated with host cardiometabolic health and gut microbiota composition

et al. 2019

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Identifying the genetic and non-genetic determinants of obesity and related cardiometabolic dysfunctions is cornerstone for their prevention, treatment, and control. While genetic variants contribute to the cardiometabolic syndrome (CMS), non-genetic factors, such as the gut microbiota, also play key roles. Gut microbiota is intimately associated with CMS and its composition is heritable. However, associations between this microbial community and host genetics are understudied. We contribute filling this gap by genotyping 60 variants in 39 genes of three modules involved in CMS risk, measuring cardiometabolic risk factors, and characterizing gut microbiota in a cohort of 441 Colombians. We hypothesized that CMS risk variants were correlated with detrimental levels of clinical parameters and with the abundance of disease-associated microbes. We found several polymorphisms in genes of innate immunity, appetite control, and energy metabolism that were associated with metabolic dysregulation and microbiota composition; the associations between host genetics and cardiometabolic health were independent of the participants' gut microbiota, and those between polymorphisms and gut microbes were independent of the CMS risk. Associations were also independent of the host genetic ancestry, diet and lifestyle. Most microbes explaining genetic-microbiota associations belonged to the families Lachnospiraceae and Ruminococcaceae. Multiple CMS risk alleles were correlated with increased abundance of beneficial microbiota, suggesting that the phenotypic outcome of the evaluated variants might depend upon the genetic background of the studied population and its environmental context. Our results provide additional evidence that the gut microbiota is under the host genetic control and present pathways of host-microbe interactions.

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Genetic association of Tumour necrosis factor alpha, Interleukin-18 and Interleukin 1 beta with the risk of coronary artery disease: A case-control study outcome from Kashmir

Cited by 6 publications

References 59 publications

Tumor necrosis factor gene polymorphism rs1800629 in patients with atherosclerotic cardiovascular diseases: A review

Tumor necrosis factor gene polymorphism rs1800629 in patients with atherosclerotic cardiovascular diseases: A review

Interleukin-1β gene rs1143634 polymorphism and cardiovascular complications in patients with coronary artery atherosclerosis

Variants in genes of innate immunity, appetite control and energy metabolism are associated with host cardiometabolic health and gut microbiota composition

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