Genetic Association Studies of MICB and PLCE1 with Severity of Dengue in Indonesian and Taiwanese Populations

Abstract

Dengue is an arboviral disease that has spread globally and become a major public health concern. A small proportion of patients may progress from symptomatic dengue fever (DF) to dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS). Findings from a previous genome-wide association study (GWAS) demonstrated that variations in the major histocompatibility complex (MHC) class I chain-related B (MICB) and the phospholipase C epsilon 1 (PLCE1) genes were related to DSS in a Vietnamese population. This study investigated associations of variations in MICB (rs3132468) and PLCE1 (rs3740360, rs3765524) with dengue severity and thrombocytopenia in both the Indonesian and Taiwanese populations. We sampled 160 patients from the Indonesian population and 273 patients from the Taiwanese population. None of the patients had DSS in the Taiwanese population. Based on age demographics, we found that dengue is more prevalent among younger individuals in the Indonesian population, whereas it has a greater impact on adults in the Taiwanese population. Our results showed the association between MICB rs3132468 and DSS. In addition, an association was identified between PLCE1 rs3740360 and DHF in secondary dengue in Indonesian patients. However, there is no association of MICB or PLCE1 variants with thrombocytopenia. This study highlights the value of genetic testing, which might be included in the clinical pathway for specific patients who can be protected from severe dengue.

Spatial Analysis on the Spread of Dengue Hemorrhagic Fever in Baubau, Southeast Sulawesi, Indonesia

“…Majority of the conducted studies in various regions of the country exhibited an increasing trend of DHF cases (i.e. Mochamad Rizal Maulana et al, 2023;Faridah et al, 2023;Dewi et al, 2021;Pasaribu et al, 2021;Nainggolan et al, 2023;Fuadzy et al, 2020;Suryadi et al, 2021;Hasana & Susanna, 2019;Rakhmani et al, 2018;Setiawati, 2019;Sasmono et al, 2020;Haryanto, 2018;O'Reilly et al, 2019;Maula et al, 2018;Wahyono et al, 2017). Hence, it remains a serious social issue not only by the medical practitioners but by different sectors of the society.…”