Genetic association study of prolylcarboxypeptidase polymorphisms with susceptibility to essential hypertension in the Yi minority of China: A case–control study based on an isolated population

Wu, Yuankui; Yang, Hongju; Xiao, Chunjie

doi:10.1177/1470320320919586

Cited by 2 publications

(3 citation statements)

References 40 publications

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“…PRCP polymorphism (E112D) is associated with hypertension, and its expression is reduced in renovascular hypertensive rats ( 80 ). Recently, a novel polymorphism (rs12290550) was found to be associated with essential hypertension in a discrete Chinese ethnic group ( 72 ). PRCP gene trap mice (PRCP gt/gt ) constitutively have a small, but significant, increase in blood pressure.…”

Section: Angiotensin II and Coronavirus Infection: Is There A Causal mentioning

confidence: 99%

Role of the renin-angiotensin system in the development of severe COVID-19 in hypertensive patients

Silva-Aguiar

Peruchetti

Rocco

et al. 2020

American Journal of Physiology-Lung Cellular and Molecular Phys

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A new form of severe acute respiratory syndrome (SARS) caused by SARS-CoV-2, called COVID-19, has become a global threat in 2020. The mortality rate from COVID-19 is high in hypertensive patients, making this association especially dangerous. There appears to be a consensus, despite the lack of experimental data, that angiotensin II (Ang II) is linked to the pathogenesis of COVID-19. This process may occur due to acquired deficiency of angiotensin-converting enzyme 2 (ACE2), resulting in reduced degradation of Ang II. Furthermore, Ang II has a critical role in the genesis and worsening of hypertension. In this context, the idea that that there is a surge in the level of Ang II with COVID-19 infection causing multiple organ injuries in hypertensive patients becomes attractive. However, the role of other components of the renin angiotensin system (RAS) in this scenario requires elucidation. The identification of other RAS components in COVID-19 hypertension may provide both diagnostic and therapeutic benefits. Here, we summarize the pathophysiologic contributions of different components of RAS in hypertension and their possible correlation with poor outcome observed in hypertensive patients with COVID-19.

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Section: Angiotensin II and Coronavirus Infection: Is There A Causal mentioning

confidence: 99%

Role of the renin-angiotensin system in the development of severe COVID-19 in hypertensive patients

Silva-Aguiar

Peruchetti

Rocco

et al. 2020

American Journal of Physiology-Lung Cellular and Molecular Phys

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show abstract

“…The study samples were selected according to the method reported previously. 7,23 The cases were diagnosed with EH according to the World Health Organization criteria for hypertension (systolic BP ⩾ 140 mm Hg and/or a diastolic BP ⩾ 90 mm Hg) and participants with secondary hypertension and other serious diseases were removed from this study. The controls with BP < 140/90 mm Hg had no history of hypertension and chronic diseases who were randomly chosen based on comparable gender and age matching hypertensive subjects.…”

Section: Subjectsmentioning

confidence: 99%

“…The PCR amplification protocol, length of target fragments and related restriction endonuclease are followed by a previously study. 23…”

Section: Snp Selection and Genotype Determinationmentioning

confidence: 99%

Haplotype-based association study between PRCP gene polymorphisms and essential hypertension in Hani minority group from a remote region of China

Pan

Jin

2020

J Renin Angiotensin Aldosterone Syst

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Objective: Prolylcarboxypeptidase (PRCP) is both involved in the Kallikrein-Kinin system (KKS) and renin-angiotensin-aldosterone system (RAAS). This study aimed to determine the genetic impact of PRCP gene polymorphisms on essential hypertension (EH) in an isolated population from a remote region of China. Methods: A haplotype-based study was investigated in 346 EH patients and 346 normal subjects and all samples were Hani minority residents in Southwest China. A total of 11 tag single nucleotide polymorphisms (SNPs) in PRCP gene were tested by polymerase chain reaction-restriction fragment length polymorphism method. Results: Single site analysis found that PRCP gene 3′UTR SNP rs3750931 was associated with EH. The minor allele G of rs3750931 was more prevalent in the EH patients compared to control subjects after Bonferroni correction ( p < 0.05). Moreover, the rs3750931 G allele carriers showed higher average blood pressure (BP) level among the subjects. The H2 (GAGCACTAACA) haplotype without rs3750931 G allele showed the protective effect for EH (OR = 0.68, 95 CI 0.54–0.85, p = 0.001). Conclusion: The present study indicated PRCP gene rs3750931 was associated with the risk of EH. This SNP G allele could be considered as one of risk markers for EH in Hani population.

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Genetic association study of prolylcarboxypeptidase polymorphisms with susceptibility to essential hypertension in the Yi minority of China: A case–control study based on an isolated population

Cited by 2 publications

References 40 publications

Role of the renin-angiotensin system in the development of severe COVID-19 in hypertensive patients

Role of the renin-angiotensin system in the development of severe COVID-19 in hypertensive patients

Haplotype-based association study between PRCP gene polymorphisms and essential hypertension in Hani minority group from a remote region of China

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