Genetic associations of inflammatory bowel disease in a South Asian population

Niriella, Madunil Anuk; Liyanage, Isurujith Kongala; Kodisinghe, S.K.; Silva, Arjuna Priyadarsin de; Rajapakshe, N.; Nanayakkara, S.D.; Luke, Dunya; Silva, Thilakshi; Nawarathne, Metthananda; Peiris, R.; Kalubovila, Udaya; Kumarasena, S. R.; Dissanayake, Vajira H. W.; Jayasekara, Rohan W.; Silva, Hithanadura Janaka de

doi:10.12998/wjcc.v6.i15.908

Cited by 10 publications

(4 citation statements)

References 27 publications

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“…A Sri Lankan case-control study published in 2018 concluded heterogenicity of allelic mutations in South Asian patients when compared to White patients [41]. Surprisingly, most SNPs and disease associations reported in this study have not been reported previously in South Asian populations.…”

Section: Genetic Determinants Of Inflammatory Bowel Disease In South ...contrasting

confidence: 68%

Literature Review of Inflammatory Bowel Disease in South Asian Populations

Waqar¹,

Raguraj²,

Chandradevan³

2023

OJGas

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Background: South Asians have been recently identified as having rapidly rising incidence of inflammatory bowel disease (IBD). There is a paucity of data regarding the phenotypic and genotypic associations of IBD among the patients of this region. Due to the rising disease prevalence, a study on South Asian population can disclose more information about the etiopathogenetic causes of the disease. Methods: Here we did a review article of IBD among South Asians. In order to get a correct sense of factors associated with the disease, we have reviewed approximately 150 articles through the PubMed search and google scholar. Results: We attempted to find temporal trends of IBD among south Asian population, compared phenotype and genotype of IBD among South Asians and western patients and looked at the patterns of IBD presentation in different countries of South Asia. We have also reviewed the differences in the incidence of IBD among South Asian immigrants and discussed the treatment challenges of IBD among this special population. Conclusion: We identified that both patients in South Asia as well as South Asian patients living in Western countries are at greater risk for all types of IBD. This geographical region provides an opportunity for revealing possible etiopathogenetic factors. Further population-based studies, comparison of studies in South Asians and immigrants from South Asian countries, and large-scale biologic treatment models need to be accelerated to control the disease burden in South Asians, as well as to achieve reduced burden globally.

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Section: Genetic Determinants Of Inflammatory Bowel Disease In South ...contrasting

confidence: 68%

Literature Review of Inflammatory Bowel Disease in South Asian Populations

Waqar¹,

Raguraj²,

Chandradevan³

2023

OJGas

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“…Interestingly there is a very large difference in the disease associated allele frequency between populations: 45.6% in the Han-Chinese, 22% in South Asians and 2.5% for the Italian cohort. [9][10][11] The current study is valuable as it demonstrates the use of non-hypothesis driven approaches to identify genetic loci important in NASH. In addition to ATGL, several other proteins were found to interact with IFGGA2, and the following 5 may provide intriguing insights: i) cytochrome P450 monooxygenase (Cyp4a14) which catalyzes the hydroxylation of saturated carbon hydrogen bonds of fatty acids has a higher abundance in NAFLD, and adenovirus-mediated overexpression of CYP4A14 in livers of C57BL/6 mice induced steatosis.…”

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confidence: 99%

From mice to humans: Unravelling the genetic levers of NASH

Mehal

2020

Journal of Hepatology

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“…UGI tract involvement is more common in CD than in UC, and it is also known that it occurs more frequently in children than adults in CD ( 12 ). Recently, studies of CD report that South Asians have more UGI tract involvement than Westerners ( 13 ), which were explained by the genetic differences according to race and the influence of food culture ( 14 , 15 ). As an extension of these studies, emerging evidence suggested that UC also presents complications in the UGI tract ( 16 , 17 ).…”

Section: Discussionmentioning

confidence: 99%

Increased Demand for Therapeutic Drugs in Pediatric Ulcerative Colitis Patients With Extraintestinal Manifestations

et al. 2022

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BackgroundUlcerative colitis (UC) is a systemic inflammatory disease with a gut predominance, which may involve other organs. The presence of extraintestinal manifestation (EIM) is an important symptom for clinicians as it alters the treatment decisions. In this study, we aimed to evaluate the initial clinical presentation and disease severity of pediatric UC patients with EIMs.MethodsOne hundred forty-two patients under the age of 18 years who were diagnosed with UC from January 2003 to November 2021 were included in this study. Forty-seven patients with confirmed EIMs and 95 patients without EIMs were divided into two groups and their differences were analyzed.ResultsThe most common EIM was peripheral arthritis. The disease extent at the time of diagnosis shows a higher rate of pancolitis in the EIM-positive group (65.9%) than that of the EIM-negative group (33.7%) (p < 0.001). More than 90% of EIM-positive patients had moderate to severe disease activity on the Mayo endoscopic subscore. In the EIM-positive group, the cumulative use of systemic steroids, immunosuppressants, and biological agents from diagnosis to 1 year follow-up were significantly higher than those of the EIM-negative group (p = 0.009, 0.001, and < 0.001, respectively). About 80% of patients in the EIM-negative group reached remission, but only about 50% of the EIM-positive patients reached remission (p = 0.005). The relapse occurred more frequently in the EIM-positive group than in the EIM-negative group with statistical significance (p < 0.001).ConclusionPediatric UC with EIMs had higher disease severity and often manifested upper gastrointestinal tract involvement. Despite EIMs treatment, the occurrence of new EIMs was observed repeatedly. Cumulative drug demand (steroids, immunosuppressants, and biological agents) for the treatment increased steadily over time, and frequent relapses occurred despite the combinatory use of therapeutic drugs.

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Genetic associations of inflammatory bowel disease in a South Asian population

Cited by 10 publications

References 27 publications

Literature Review of Inflammatory Bowel Disease in South Asian Populations

Literature Review of Inflammatory Bowel Disease in South Asian Populations

From mice to humans: Unravelling the genetic levers of NASH

Increased Demand for Therapeutic Drugs in Pediatric Ulcerative Colitis Patients With Extraintestinal Manifestations

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