Genetic background of lumbosacral transitional vertebrae in German shepherd dogs

Gluding, D; Stock, K. F.; Tellhelm, Bernd; Krämer, Martin; Eley, Nele

doi:10.1111/jsap.13380

Cited by 6 publications

(2 citation statements)

References 19 publications

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“…Transitional vertebrae at any region junction are characterized by features retained from two adjacent regions in the vertebral column (Brocal et al 2018). In dogs the lumbosacral transitional vertebrae predispose to premature degeneration of the lumbosacral disc and a genetic predisposition has been proposed (Morgan 1999;Damur-Djuric et al 2006;Gong et al 2020;Gluding et al 2021). The clinical consequence of cervicothoracic and thoracolumbar transitional vertebrae in dogs needs to be explored.…”

Section: Transitional Vertebraementioning

confidence: 99%

Phenotypic and genotypic characterization of a myelopathy in pugs : A journey from ’wobbly pugs’ to pug dog myelopathy

Rohdin¹

2022

Acta Universitatis Agriculturae Sueciae

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In summary, gait abnormalities were common in Swedish pugs and the character of the abnormal gait suggesting an underlying spinal cord disorder. The lack of association between presence, or type, of CVMs in the thoracolumbar vertebral column and neurological deficits, paraparesis and ataxia, suggested that other or additional factors were important for the development of PDM. Neuropathological examination showed that the clinical disease, PDM, was caused by the formation of profound meningeal fibrosis that interfered with the vascular supply to the spinal cord as well as caused obstruction of cerebrospinal fluid (CSF) flow with subsequent parenchymal spinal cord destruction. In addition a considerable number of PDM pugs presented with inflammation in the central nervous system. A contribution of the immunological system on the development of PDM was supported by the finding of anti-GFAP autoantibodies in the CSF of pugs with PDM. Our results also indicated that the DLA class II risk haplotype for necrotizing meningoencephalitis (NME), even in a heterozygous state, may cause a more severe PDM phenotype. The potential relevance of multiple candidate genes to the pathogenesis of PDM, including those implicated with bone homeostasis, the differentiation of cartilage, inflammation and fibrotic scar tissue formation, should be confirmed in future studies.

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Section: Transitional Vertebraementioning

confidence: 99%

Phenotypic and genotypic characterization of a myelopathy in pugs : A journey from ’wobbly pugs’ to pug dog myelopathy

Rohdin¹

2022

Acta Universitatis Agriculturae Sueciae

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“…Transitional vertebra is considered a congenital anomaly, which occurs in various species of animals and in humans [2,6] and its presence can be clinically significant [7]. It's supposed to exist a hereditary predisposition to transitional vertebra [8][9][10][11]. Transitional vertebrae can appear in any junction of the spine presenting common characteristics of both adjacent vertebral segments.…”

Section: Introductionmentioning

confidence: 99%

Transitional and/or Supernumerary Vertebra in Lumbosacrocaudal Region of the Spine – a Reality in All Domestic Mammals

Covașă

2023

Preprint

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Transitional vertebra has been reported along of the spine in many researches focused especially on carnivores. The current study had the objectives to identify the presence of transitional lumbosacral and sacrocaudal vertebra in domestic mammals, to realize a comparative analysis of the localization and conformation of this abnormal condition. For this purpose the researches included animals belonging to next species: cow – 29 specimens, sheep – 32 specimens, horse – 31 specimens, pig – 26 specimens, rabbit – 33 specimens, dog – 89 specimens and cat – 57 specimens. The most of the animals, respectively their spine were analysed post mortem, after the dissection performed in the anatomy laboratory, except the dogs and 48 cats that were examined radiologically. The investigations revealed the presence of transitional vertebra in all species as follow: in cows – 3 cases (8,7%), all being about the lumbarization of first sacral vertebra (S1); in sheep – 3 cases (9,37%), two lumbarization cases of S1 and one caudalisation of S4 (the last sacral vertebra); in horses – 4 cases (12,9%), all about the sacralisation of Cd1 (first caudal vertebra); in pigs – 3 cases (11,53%), two lumbarisation cases of S1 and one sacralisation of Cd1; in rabbits – 3 cases (9,09%), a lumbar supernumerary vertebra (L8) and two cases of caudalisation of S4; in dogs – 4 cases (4,49%), a lumbar supernumerary vertebra (L8) and 3 cases of sacralisation of last lumbar vertebra (L7 or L8); in cats – 3 cases (5,26%), two sacralisation cases of last lumbar vertebra and one caudalisation of last sacral vertebra (S3). A strong lumbarization process was observed in ruminants (especially in cows), then in pigs, the sacralisation being prevalent in carnivores. The sacrocaudal transitional vertebrae was predominant in horses, but occurred as an ossification process especially in old animals.

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Canine Mobility Maintenance and Promotion of a Healthy Lifestyle

Ramos

Otto

2022

Veterinary Clinics of North America: Small Animal Practice

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Genetic background of lumbosacral transitional vertebrae in German shepherd dogs

Cited by 6 publications

References 19 publications

Phenotypic and genotypic characterization of a myelopathy in pugs : A journey from ’wobbly pugs’ to pug dog myelopathy

Phenotypic and genotypic characterization of a myelopathy in pugs : A journey from ’wobbly pugs’ to pug dog myelopathy

Transitional and/or Supernumerary Vertebra in Lumbosacrocaudal Region of the Spine – a Reality in All Domestic Mammals

Canine Mobility Maintenance and Promotion of a Healthy Lifestyle

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