Increasing the production of dairy and meat products is becoming more and more important in connection with the growth of the population and the increase in demand for these products. In order to meet the needs of the consumer in this matter, directions for increasing the reproductive capacity of livestock are constantly being developed, because this issue is becoming more acute every year. The aim of the study was to establish the dependence of biochemical indicators, such as the content of total protein, albumins, the ratio of albumins to globulins and alkaline phosphatase with indicators of reproducibility. Blood serum was used to determine biochemical parameters. The method for determining the content of total protein, albumins, alkaline phosphatase activity was based on the use of the spectrophotometric method. Statistical analysis was performed using Microsoft Excel. According to the results of our research, a statistical interdependence of the protein content with indicators of the service period, reproducibility, and insemination index was established, where the correlation dependence was within r= (-0.471 – (-0.809)) with a probable error (P<0.001). A correlation dependence of alkaline phosphatase activity with indicators of reproducibility was established, which had statistical limits of r= 0.602 to -0.722 with a probable error (P<0.001). During the analysis of scientific works, a similarity was established in the dependence of changes in biochemical blood parameters and their influence on the reproductive capacity of the cow herd. These changes in the application of food additives in the diet of animals to correct metabolism, which led to changes in biochemical indicators and improvement of reproductive capacity, are quite clearly traced.