Genetic basis for rapidly evolved tolerance in the wild: adaptation to toxic pollutants by an estuarine fish species

Nacci, Diane; Proestou, Dina; Champlin, Denise; Martinson, John; Waits, Eric R.

doi:10.1111/mec.13848

Cited by 35 publications

(50 citation statements)

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“…F2 embryos were genotyped using a dense panel of markers including targeted SNPs (Proestou et al., 2014) and microsatellite markers (Waits et al., 2016). The statistical linkage between phenotype and genetic markers was accomplished using a QTL mapping approach (Nacci, Proestou, Champlin, Martinson, & Waits, 2016). Mapping was conducted before the F. heteroclitus reference genome was available, so QTL markers were aligned to other fish genomes to reveal the identity of nearby genes.…”

Section: Genetic Basis Of Pollution Tolerance In Killifishmentioning

confidence: 99%

When evolution is the solution to pollution: Key principles, and lessons from rapid repeated adaptation of killifish (Fundulus heteroclitus) populations

Whitehead

Clark

Reid

et al. 2017

Evolutionary Applications

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128

102

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For most species, evolutionary adaptation is not expected to be sufficiently rapid to buffer the effects of human‐mediated environmental changes, including environmental pollution. Here we review how key features of populations, the characteristics of environmental pollution, and the genetic architecture underlying adaptive traits, may interact to shape the likelihood of evolutionary rescue from pollution. Large populations of Atlantic killifish (Fundulus heteroclitus) persist in some of the most contaminated estuaries of the United States, and killifish studies have provided some of the first insights into the types of genomic changes that enable rapid evolutionary rescue from complexly degraded environments. We describe how selection by industrial pollutants and other stressors has acted on multiple populations of killifish and posit that extreme nucleotide diversity uniquely positions this species for successful evolutionary adaptation. Mechanistic studies have identified some of the genetic underpinnings of adaptation to a well‐studied class of toxic pollutants; however, multiple genetic regions under selection in wild populations seem to reflect more complex responses to diverse native stressors and/or compensatory responses to primary adaptation. The discovery of these pollution‐adapted killifish populations suggests that the evolutionary influence of anthropogenic stressors as selective agents occurs widely. Yet adaptation to chemical pollution in terrestrial and aquatic vertebrate wildlife may rarely be a successful “solution to pollution” because potentially adaptive phenotypes may be complex and incur fitness costs, and therefore be unlikely to evolve quickly enough, especially in species with small population sizes.

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Section: Genetic Basis Of Pollution Tolerance In Killifishmentioning

confidence: 99%

When evolution is the solution to pollution: Key principles, and lessons from rapid repeated adaptation of killifish (Fundulus heteroclitus) populations

Whitehead

Clark

Reid

et al. 2017

Evolutionary Applications

Self Cite

128

102

View full text Add to dashboard Cite

show abstract

“…In fact, while the strong mechanistic explanation in Atlantic tomcod was sufficient to explain the differential resistance, there has been no further search to find any other genes under selection in these populations (Wirgin et al., 2011). In such cases, genomic methods may be employed to conduct a top‐down approach to identify differences between genomes of reference and resistant populations without a priori knowledge of the mechanisms involved or the genomic regions impacted (Nacci, Proestou, Champlin, Martinson, & Waits, 2016). …”

Section: Evolutionary and Population Genomicsmentioning

confidence: 99%

“…One aspect of genomic investigations, the quantitative trait loci (QTL) approach, links resistant phenotypes with specific genomic regions or number of loci based on crosses of resistant and reference individuals (Martinez & Levinton, 1996). This approach has been recently combined with the use of microsatellite and single nucleotide polymorphism (SNP) data and was successful in both identifying genetic regions likely under selection, as well as the gene–gene epistatic interactions that were likely to have conferred resistance in individuals (Nacci et al., 2016). In addition, combining this method with linkage disequilibrium between explored loci allows for the creation of a physical map of the explored genome and for synteny analysis between related species (Waits et al., 2016).…”

Section: Evolutionary and Population Genomicsmentioning

confidence: 99%

“…In addition, combining this method with linkage disequilibrium between explored loci allows for the creation of a physical map of the explored genome and for synteny analysis between related species (Waits et al., 2016). The strengths of the QTL approach lie in the power of finding individual genome region contributions to resistance, as well as the contribution of region–region interactions to level of resistant phenotype (Nacci et al., 2016). On the other hand, while the strong roots of QTL analysis in quantitative genetics allow it to link a region of the genome to a phenotype of resistance in a quantitative fashion, it may be unable to ascribe observed resistance to specific genes (Nacci et al., 2016).…”

Section: Evolutionary and Population Genomicsmentioning

confidence: 99%

“…The strengths of the QTL approach lie in the power of finding individual genome region contributions to resistance, as well as the contribution of region–region interactions to level of resistant phenotype (Nacci et al., 2016). On the other hand, while the strong roots of QTL analysis in quantitative genetics allow it to link a region of the genome to a phenotype of resistance in a quantitative fashion, it may be unable to ascribe observed resistance to specific genes (Nacci et al., 2016). As there are often multiple genes on a single QTL identified to be related to adaptation, inferences can be made as to which genes on that QTL would best explain the adaptation mechanistically, but the resolution of microsatellite and SNP data is insufficient to assign the resistance to a specific genotype.…”

Section: Evolutionary and Population Genomicsmentioning

confidence: 99%

See 2 more Smart Citations

Evolutionary toxicology in an omics world

Oziolor

Bickham

Matson

2017

Evolutionary Applications

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Evolutionary toxicology is a young field that has grown rapidly in the past two decades. The potential of this field comes from the ability to link chemical contamination to multigenerational and population‐wide effects in various species. The advancements and rapidly decreasing costs of ‐omic tools are improving the power and resolution of evolutionary toxicology studies. In this manuscript, we aim to address the trajectories and perspectives for conducting evolutionary toxicology studies with ‐omic approaches. We discuss the complementarity of using multiple ‐omic tools (genomics, eDNA, transcriptomics, proteomics, and metabolomics) for utility in understanding the toxicological relevance of adaptive responses in populations. In addition, we discuss phenotypic plasticity and its relevance to transcriptomic studies in toxicology. As evolutionary toxicology grows and expands its capacity to link toxicology with population‐wide end points, we emphasize the applications of such studies in answering questions about ecological and population health, as well as future applicability to regulation. Thus, we aim to emphasize the enormous potential for evolutionary toxicology in an ‐omics world and give perspectives on the directions of future investigations.

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Evolutionary Toxicology—An Informational Tool for Chemical Regulation?

Oziolor

DeSchamphelaere

Lyon

et al. 2020

Enviro Toxic and Chemistry

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The Challenge:Evolutionary toxicology focuses on the drivers, mechanisms, and outcomes of pollution-driven genetic differentiation among populations. The focal questions address the types of chemical contamination acting as selective pressures; the genetics, epigenetics, and demography of impacted populations; as well as fitness costs and cross-resistances that may follow rapid adaptation. In this field, researchers incorporate tools from environmental chemistry, conservation genetics, population biology, and toxicology to understand the health and stability of impacted populations.Recent studies in evolutionary toxicology have illustrated diverse cases of population-wide adaptation to contamination (killifish, Hyalella, mosquitofish). Adaptation, by definition, is achieved through the localized loss of some individuals and genotypes and, thus, provides singular evidence of losses in biodiversity. Chemical regulations are generally supported by assessments that predict, largely through laboratory studies, the risks associated with chemical exposures. Evolutionary toxicology complements this approach by providing direct evidence of population and community impacts. Recent interest by the Society of Environmental Toxicology and Chemistry working group EVOGENERATE (Evolutionary and Multigenerational Effects of Chemicals) has launched discussions about the utility of evolutionary toxicology studies to inform chemical regulation. To further this discussion, one representative from each of 3 sectors, academia, government, and industry, was asked to provide opinions on the following questions:1) The considerable number of adaptive events reported in recent years suggests that current risk-assessment methods may not be exhaustive. What is risk assessment missing by not incorporating evolutionary toxicology endpoints to inform the regulation of toxic compounds? 2) Changes in the US Toxic Substances Control Act call for attention in 2 major aspects of predictive toxicology: organizational frameworks (e.g., adverse outcomes pathway) and fast screening methods (e.g., Omics, Tox21). Can evolutionary toxicology contribute to these advancements? 3) What needs to be done to make an evolutionary approach more accessible and useful to chemical regulation?

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Genetic basis for rapidly evolved tolerance in the wild: adaptation to toxic pollutants by an estuarine fish species

Cited by 35 publications

References 60 publications

When evolution is the solution to pollution: Key principles, and lessons from rapid repeated adaptation of killifish (Fundulus heteroclitus) populations

When evolution is the solution to pollution: Key principles, and lessons from rapid repeated adaptation of killifish (Fundulus heteroclitus) populations

Evolutionary toxicology in an omics world

Evolutionary Toxicology—An Informational Tool for Chemical Regulation?

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