Genetic Basis of Orofacial Pain and Temporomandibular Joint Dysfunction

Vieira, Alexandre R.

doi:10.1007/978-3-030-14485-2_9

Cited by 1 publication

(1 citation statement)

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“…The sample is typically collected at the first visit, before any necessary dental treatment is performed. From 5,025 records of participants in the Dental Registry and DNA Repository project, we selected 865 adults (513 females) that required more than one anesthetic tube to allow for a single posterior tooth restoration to be performed and compared to 365 adults (206 females) that did not need more than one tube to perform similar work (17). Although, it can be argued that differences in anatomical structures, metabolism, and presence of infection may account for the need to give additional anesthetic solution to perform regular dental treatments, the assumption is that by matching subjects by the procedures done, the need for additional anesthetic solution may be related to higher levels of pain sensitivity.…”

Section: Introductionmentioning

confidence: 99%

Classical trigeminal neuralgia is associated with gephyrin and sodium voltage-gated channel alpha subunit 8

2023

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Trigeminal neuralgia is highly debilitating, and its etiology is still undefined. The goal of this work was to define associations between well-characterized trigeminal neuralgia cases and common genetic variants in the population. two hundred and fifty-seven individuals diagnosed with classical trigeminal neuralgia were compared to 865 individuals without classical trigeminal neuralgia and with an assessment for lower or higher pain threshold based on the amount of anesthetic required for routine dental treatment. Genotypes of 24 variants marking genes in the VGSC (voltage-gated sodium channels) or GABA (gamma-aminobutyric acid) pathways were obtained using TaqMan chemistry end end-point analysis. Chi-square was used for all comparisons with an alpha of 0.002. An association between classical trigeminal neuralgia and individuals requiring less or more anesthetic for routine dental treatments showed associations with SCN8A rs1601012 and GPHN rs723432 (p = 0.0009 and p = 0.0002, respectively). In conclusion, classical trigeminal neuralgia is associated with SCN8A and GPHN and markers rs1601012 rs723432 may be useful to determine individual risks for the condition.

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Section: Introductionmentioning

confidence: 99%