2004
DOI: 10.1007/s00414-004-0456-1
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Genetic characteristics and population study of 4 X-chromosomal STRs in Koreans: evidence for a null allele at DXS9898

Abstract: The four X-chromosomal short tandem repeats (STRs), DXS9898, DXS6809, DXS7424 and DXS10011 were analyzed by single multiplex PCR in 150 male and 150 female Koreans. The loss of an allele at DXS9898 was observed in 13 out of 450 chromosomes (2.9%) and the PCR analysis showed that the X-chromosome with a null allele at DXS9898 has more than 1 kb deletion at the DXS9898 locus. Statistical analyses for these four X-STRs showed that they are highly informative for forensic application in Koreans. No linkage disequi… Show more

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Cited by 36 publications
(27 citation statements)
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“…However, when dealing with haplotypes of closely linked loci, the fact that LD may vary in different populations has to be taken into account. Whilst our group observed a strong LD between DXS101 and DXS7424 [7], other authors [10] failed to indicate the same phenomenon in a Korean population.…”
Section: Discussionmentioning
confidence: 74%
“…However, when dealing with haplotypes of closely linked loci, the fact that LD may vary in different populations has to be taken into account. Whilst our group observed a strong LD between DXS101 and DXS7424 [7], other authors [10] failed to indicate the same phenomenon in a Korean population.…”
Section: Discussionmentioning
confidence: 74%
“…It is recognised that factors other than the physical distance between loci are involved [15,17]. Indeed, the X chromosome appears to be rather prone to recombination, and an absence of linkage has been reported in other studies, even when quite close markers were studied [8,18].…”
Section: Discussionmentioning
confidence: 93%
“…However, although frequencies from different continents have been published (for instance, see [2,[8][9][10]), it is unclear to which extent Xlinked markers display differences at the regional level. This is an important issue in order to decide which database is needed to interpret DNA results.…”
Section: Introductionmentioning
confidence: 97%
“…Blood or buccal samples from 450 unrelated Koreans living in Seoul (300 men and 150 women), including 150 men and 150 women already typed for 9 X-STRs (13,14), were analyzed. Genomic DNA was extracted using a QIAamp DNA Mini Kit (Qiagen, Hilden, Germany) according to the manufacturer's instructions, and the DNA was quantitated using NanoDrop 1000 spectrophotometer (Thermo Fisher Scientific, Wilmington, DE, USA), following the manufacturer's recommendation.…”
Section: Materials and Methods Dna Samplesmentioning
confidence: 99%