Genetic characterization of human bocavirus among children with severe acute respiratory infection in China

Abstract

We described some new characteristics in the epidemiology of HBoV among children with SARI, these data will significantly expand the current knowledge of HBoV epidemic and genomic characterization among children with SARI.

Comparison of viral and epidemiological profiles of hospitalized children with severe acute respiratory infection in Beijing and Shanghai, China

“…It may be that HCoV infections occur as biennial outbreaks in Shanghai [16,[34][35][36][37]. Previous studies have shown that, although HBoV infections occur throughout the year, they are most evident during the winter and spring months [6,38,39]. In contrast, we found that HBoV infections were most common during the summer months in Beijing and Shanghai.…”

“…The second round consisted of 94°C for 5 min; then 94°C for 40 s, 55°C for 40 s, and 72°C for 40 s for 25 cycles; and then 72°C for 5 min. HBoV was detected using a nested PCR method as described previously [6]. The nested PCR programs were performed in two cycles as follows.…”

“…Severe acute respiratory infection (SARI) is the leading cause of hospitalization in children and of febrile episodes in infants younger than 3 months old [3,4]. The most common cause of SARI in children is viral infections [5][6][7][8][9][10], including influenza viruses A and B (Flu A/B); respiratory syncytial virus (RSV); adenovirus (ADV); parainfluenza virus (PIV) 1-3; picornavirus (PIC), which mainly includes human rhinovirus (RV) and human enterovirus (EV); human coronaviruses (HCoV), which includes OC43, 229E, NL63, and HKU; human bocavirus (HBoV); and human metapneumovirus (HMPV). Although the viral and epidemiological profiles of pediatric patients with SARI vary among countries [4,[7][8][9][10][11][12][13][14][15], few studies have comprehensively compared the viral and epidemiological profiles of pediatric patients with SARI in different geographic areas or climate zones within the same country, such as China.…”

Respiratory viruses in healthy infants and infants with cystic fibrosis: a prospective cohort study

“…An additional indicator of different reactions to viruses already in early life might be the surprisingly high number of hBoV detection in our CF cohort. As hBoV is a relatively newly discovered virus, with an unknown role in lung disease, but a probable role in ARTIs,40 further studies are needed for the interpretation of this finding 41…”

Metagenomic analysis identified co-infection with human rhinovirus C and bocavirus 1 in an adult suffering from severe pneumonia

“…1,2 Recent articles in this journal have highlighted the role of bocavirus and rhinovirus in potentially severe pneumonia in adults and younger children. 3,4 However co-infection with both viruses was very rare among adults. A previous study reported a 16-month child who was infected by HBoV1 and also showed presence of HRV, developed severe pneumonia.…”