Genetic Characterization of Human Enteroviruses Associated with Hand, Foot and Mouth Diseases in Poland, 2013–2016

Wieczorek, Magdalena; Ciąćka, Agnieszka; Krzysztoszek, Arleta; Figas, Agnieszka; Szenborn, Leszek

doi:10.5604/01.3001.0010.4889

Cited by 5 publications

(7 citation statements)

References 15 publications

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“…Co-circulation of CV-A6 with CV-A10 and CV-A16 was already reported previously [7,39] and in a study of HFMD cases in Poland between 2013-2016 the emergence and cocirculation of CV-A6 with CV-A10 and CV-A16 was also confirmed [9]. In our study CV-A6, CV-A16 and EV-71 were the only three types identified in specimens associated with HFMD, however only CV-A6 was detected in any HFMD samples since 2013.…”

Section: Discussionsupporting

confidence: 79%

“…A change in the clinical phenotype of CV-A6 became evident when a large outbreak of HFMD caused by CV-A6 in Finland in 2008 was reported [6]. This was followed by several reports of CV-A6 associated HFMD from Europe [7][8][9], North America [10,11] and Asia [12][13][14][15]. In the last decade CV-A10 was also reportedly an agent of HFMD [16,17].…”

Section: Introductionmentioning

confidence: 99%

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Distribution of enterovirus genotypes detected in clinical samples in Hungary, 2010–2018

Bujaki

Farkas

Rigó

et al. 2020

AMicr

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This report provides the findings of a retrospective surveillance study on the emergence and circulation of enteroviruses with their associated clinical symptoms over a nine-year period detected at the National Enterovirus Reference Laboratory in Hungary between 2010–2018.Enterovirus (EV) detection and genotyping were performed directly from clinical samples. From 4,080 clinical specimens 25 EV types were identified with a median age of patients of 5 years and 68% of all cases affected children aged 10 years or younger, although infections occurred in all age-groups. In 130 cases neurological symptoms were recorded, in 123 cases the infection presented in skin related signs including hand, foot, and mouth disease (HFMD), herpangina and rash. In 2010 EV-A71 was found to cause the majority of diagnosed EV infections while in 2011 and from 2014–2018, Coxsackievirus (CV)-A6 was identified most often. Echovirus E6 accounted for the most cases in 2012 and Echovirus 30 dominated in 2013. EV-D68 was identified only in 2010 and 2013.Widespread circulation of several EV-A and EV-B viruses with occasional occurrence of EV-C and EV-D was detected. The ability of EVs to cause severe infections in sporadic cases and regular outbreaks highlight the importance of continued monitoring of circulating EV types.

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Section: Discussionsupporting

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Distribution of enterovirus genotypes detected in clinical samples in Hungary, 2010–2018

Bujaki

Farkas

Rigó

et al. 2020

AMicr

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“…6-10 CV-A6 and CV-A10 are the most common serotypes for mild HFMD worldwide and in China since 2010. 11-18 We found that the number of HFMD cases has increased since the nationwide HFMD outbreak in China in 2008; HFMD has been the leading cause of significant mortality in China since 2013 to present, according to the report of National Health Commission of the People’s Republic of China.…”

Section: Introductionmentioning

confidence: 96%

“…Coxsackievirus A6 (CV-A6) and coxsackievirus A10 (CV-A10) are the most common serotypes for mild HFMD worldwide and in China since 2010 [11][12][13][14][15][16][17][18]. We found that the number of HFMD cases has increased very much since the nationwide HFMD outbreak in China in 2008, and the number of HFMD cases has been the head of the lethal infectious diseases in our country for five consecutive years since 2013, according to the report of National Health Commission of the People's Republic of China.…”

Section: Introductionmentioning

confidence: 99%

The Epidemiological and Clinical Characteristics of Hand, Foot, and Mouth Disease in Hangzhou, China, 2016 to 2018

Wang

Zhou

Xie

et al. 2020

Clin Pediatr (Phila)

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Hand, foot, and mouth disease (HFMD) is most frequently caused by several serotypes of human enterovirus (EV) including Enterovirus 71 (EV-A71), coxsackievirus A16 (CV-A16), or other types of EV. The aim of this study was to determine the epidemiological characteristics of HFMD and to describe the epidemiologic characteristics of HFMD among severe and mild cases. We collected 4760 HFMD cases in Hangzhou from 2016 to 2018. Specimens from these cases were collected and tested for EV-A71, CV-A16, CV-A6, CV-A10, CV-A2, and CV-A5 by reverse transcriptase polymerase chain reaction. From 2016 to 2018, the prevalence of HFMD was seasonal each year. Among the 4760 probable HFMD cases, 3559 cases were confirmed (74.8%), including 426 cases of EV-A71 infections (8.9%), 249 cases of CV-A16 infections (5.2%), and 2884 cases of other EV infections (60.6%). The percentage of other EV infections was more than 80%, which increased year by year. Random selection of samples for detection of other EV infections in 2017 and 2018, among the 1297 cases, showed there were 835 (64.4%) cases of CV-A6 infections, 177 (13.6%) cases of CV-A10 infections, 100 (7.7%) cases of CV-A2 infections, 40 (3.1%) cases of CV-A5 infections, 3 (0.02 %) cases of mixed infections, and 11.0% untyped EV infections. Preschool children were still the primary population susceptible to HFMD. In severe cases, EV-A71 infection was the main cause. Characterizing the epidemiology and the relationship between severe and common cases of HFMD would provide relevant evidences for the prevention and treatment of HFMD.

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Section: Introductionmentioning

confidence: 99%

The epidemiological and clinical characteristics of hand, foot and mouth disease in Hangzhou, China, 2016-2018

Wang

Zhou

Xie

et al. 2019

Preprint

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Background Hand, foot and mouth disease (HFMD) is most frequently caused by several serotypes of human enterovirus (EV) including Enterovirus 71 (EV71), Coxsackievirus A16 (CV-A16) or other types of EV. Children under 5 years old are the most susceptible to HFMD. The aim of this study was to determine the epidemiological characteristics and the relationship between severe and mild HFMD. Methods We collected 4760 probable HFMD cases with skin papular or vesicular rashes on the hands, feet, mouth or buttocks in Hangzhou from 2016 to 2018. Specimens of these cases were collected and the pathogen of EV71, CV-A16, CV-A6, CV-A10, CV-A2 and CV-A5 was classified by RT-PCR. Then the pathogen distribution and clinical status of children with HFMD were described. Results From Jan. 1, 2016 to Dec. 31, 2018, the incidence and prevalence of HFMD were seasonal each year. Among the 4760 probable HFMD cases, 3559 cases were confirmed (74.8%, 3559/4760), including 426 cases of EV71 infections (8.9%, 426/4760, 249 cases of CV-A16 infections (5.2%, 249/4760) and 2884 cases of other enteroviruses infections (60.6%, 2884/4760). The percentage of EV positive HFMD cases with non-EV71 and non-CV-A16 was more than 80% (2884/3559), which increased year by year. The percentage of EV71 decreased year by year in the last three years especially in 2018. Among the 1297 cases randomly selected of other EV infections in 2017 and 2018, there were 835 (64.4%) cases of CV-A6 infections, 177 (13.6%) cases of CV-A10 infections, 100 (7.7%) cases of CV-A2 infections, 40 (3.1%) cases of CV-A5 infections, 3 (0.02%) cases of mixed infections and 11.0% untyped enteroviruses infections. Preschool children were still the primary population susceptible to HFMD, and the age of the children infected with other enteroviruses tended to be younger. In severe cases, EV71 infection was the main cause. Conclusions The other EV especially CV-A6 increased obviously and EV71 decreased obviously in the three years. Characterizing the epidemiology and the relationship between severe and common cases of HFMD would provide relevant evidences for the prevention and treatment of HFMD.

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Genetic Characterization of Human Enteroviruses Associated with Hand, Foot and Mouth Diseases in Poland, 2013–2016

Cited by 5 publications

References 15 publications

Distribution of enterovirus genotypes detected in clinical samples in Hungary, 2010–2018

Distribution of enterovirus genotypes detected in clinical samples in Hungary, 2010–2018

The Epidemiological and Clinical Characteristics of Hand, Foot, and Mouth Disease in Hangzhou, China, 2016 to 2018

The epidemiological and clinical characteristics of hand, foot and mouth disease in Hangzhou, China, 2016-2018

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