Genetic characterization of Mycobacterium bovis BCG Mexico 1931

Abstract

s e455 swab) nucleotide difference in VP1 compared with the Sabin strain. These results confirm the presence of an iVDPV1. The sequences of 5ǐNCR showed the 480 nucleotide change, proving the reversion of the sabin strain to the infectivity. These findings were sent to the National Program in less than 15 days.Results: After the detection of AFP notification was sent to the field, Epidemiology actions were made as in all cases. In the investigation three different locations were established as the child residence. All of them were visited and vaccination of all children under 18 years old was done. A national and international alert were sent Active community surveillance was made and contact and environmental samples were collected and sent to the Regional Lab. In none of them the iVDPV 1 was detected. Four serial samples from the case were taken each month, in all of them the same iVDPV1 was isolated.Conclusion: The country has sustained the surveillance of AFP through 22 years based on the collaborative work between the laboratory and the epidemiologists. No other cases appeared although the vaccine coverage in one of the district was very low. As consequence of this finding a national vaccination campaign was made. Although poliomyelitis is a threat to the region Argentine is ready to face it.