Genetic characterization of the complete genome of an Aleutian mink disease virus isolated in north China

Xi, Ji; Wang, Jigui; Yu, Yongle; Zhang, Xiaomei; Mao, Yuxin; Hou, Qiang; Liu, Weiquan

doi:10.1007/s11262-016-1320-3

Cited by 15 publications

(3 citation statements)

References 49 publications

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“…Some studies have in fact performed phylogenetic analyses of the AMDV genomes deciphered by genetic sequencing. This was performed in order to develop new tools for outbreak investigation, the determination of virulence markers and development of more sensitive diagnostic tests in the future [ 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 ]. As an example of such work, Canuti et al [ 93 ] studied the evolutionary dynamics of AMDV from 2004 to 2014 using sequences obtained from many regions of the world, including North America and Europe.…”

Section: Amdv Preventative Measuresmentioning

confidence: 99%

AMDV Vaccine: Challenges and Perspectives

Markarian

Abrahamyan

2021

Viruses

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Aleutian mink disease virus (AMDV) is known to cause the most significant disease in the mink industry. It is globally widespread and manifested as a deadly plasmacytosis and hyperglobulinemia. So far, measures to control the viral spread have been limited to manual serological testing for AMDV-positive mink. Further, due to the persistent nature of this virus, attempts to eradicate Aleutian disease (AD) have largely failed. Therefore, effective strategies to control the viral spread are of crucial importance for wildlife protection. One potentially key tool in the fight against this disease is by the immunization of mink against AMDV. Throughout many years, several researchers have tried to develop AMDV vaccines and demonstrated varying degrees of protection in mink by those vaccines. Despite these attempts, there are currently no vaccines available against AMDV, allowing the continuation of the spread of Aleutian disease. Herein, we summarize previous AMDV immunization attempts in mink as well as other preventative measures with the purpose to shed light on future studies designing such a potentially crucial preventative tool against Aleutian disease.

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Section: Amdv Preventative Measuresmentioning

confidence: 99%

AMDV Vaccine: Challenges and Perspectives

Markarian

Abrahamyan

2021

Viruses

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“…Some studies have in fact performed phylogenetic analyses of the AMDV genomes deciphered by genetic sequencing. This is done in order to develop new tools for outbreak investigation, determination of virulence markers, and development of more sensitive diagnostic tests in the future [132][133][134][135][136][137][138][139]. As an example of such work, Canuti et al [133] studied the evolutionary dynamics of AMDV from 2004 to 2014 using sequences obtained from many regions of the world, including North America and Europe.…”

Section: Amdv Preventative Measuresmentioning

confidence: 99%

AMDV Vaccine: Challenges and Perspectives

Markarian

Abrahamyan

2021

Preprint

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Aleutian mink disease virus (AMDV) is known to cause the most significant disease in the mink industry. It is globally widespread and manifested as a deadly plasmacytosis and hyperglobulinemia. So far, measures to control viral spread have been limited to manual serological testing for AMDV-positive mink. Further, due to the persistent nature of this virus, attempts to eradicate Aleutian disease (AD) have largely failed. Therefore, effective strategies to control viral spread are of crucial importance for wildlife protection. One potentially key tool in the fight against this disease is by immunization of mink against AMDV. Throughout many years, several researchers have tried to develop AMDV vaccines and demonstrated varying degrees of protection in mink by those vaccines. Despite these attempts, there are currently no vaccines available against AMDV, allowing the continuation of the spread of Aleutian disease. Herein, we summarize previous AMDV immunization attempts in mink as well as other preventative measures with the purpose to shed light on future studies designing such a potentially crucial preventative tool against Aleutian disease.

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“…At present, only a few molecular epidemiological reports of AMDV isolated from tissue or blood have been studied [ 9 – 11 ]. Since AMD infection can be transmitted in the mink farming industry through feces, fecal samples are feasible for detecting AMDV.…”

Section: Introductionmentioning

confidence: 99%

Molecular epidemiology of Aleutian mink disease virus from fecal swab of mink in northeast China

et al. 2020

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Background: Aleutian mink disease parvovirus (AMDV) causes Aleutian mink disease (AMD), which is a serious infectious disease of mink. The aim of this study was to get a better understanding of the molecular epidemiology of AMDV in northeast China to control and prevent AMD from further spreading. This study for the first time isolated AMDV from fecal swab samples of mink in China. Results: A total of 157/291 (54.0%) of the fecal swab samples were positive for AMDV. Of these, 23 AMDV positive samples were randomly selected for sequence alignment and phylogenetic analysis based on the acquired partial fragments of VP2 gene with the hypervariable region. Comparative DNA sequence analysis of 23 AMDV isolates with a reference nonpathogenic (AMDV-G) strain revealed 8.3% difference in partial VP2 nucleotide sequences. Amino acid alignment indicated the presence of several genetic variants, as well as one single amino acid residue deletion. The most concentrated area of variation was located in the hypervariable region of VP2 protein. According to phylogenetic analysis, the Chinese AMDV strains and the other reference AMDV strains from different countries clustered into three groups (clades A, B and C). Most of the newly sequenced strains were found to form a Chinese-specific group, which solely consisted of Chinese AMDV strains. Conclusion: These findings indicated that a high genetic diversity was found in Chinese AMDV strains and the virus distribution were not dependent on geographical origin. Both local and imported AMDV positive species were prevalent in the Chinese mink farming population. The genetic evidence of AMDV variety and epidemic isolates have importance in mink farming practice.

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Genetic characterization of the complete genome of an Aleutian mink disease virus isolated in north China

Cited by 15 publications

References 49 publications

AMDV Vaccine: Challenges and Perspectives

AMDV Vaccine: Challenges and Perspectives

AMDV Vaccine: Challenges and Perspectives

Molecular epidemiology of Aleutian mink disease virus from fecal swab of mink in northeast China

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