2019
DOI: 10.1128/jvi.01969-18
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Genetic Compatibility of Reassortants between Avian H5N1 and H9N2 Influenza Viruses with Higher Pathogenicity in Mammals

Abstract: Close interaction between avian influenza (AI) viruses and humans in Egypt appears to have resulted in many of the worldwide cases of human infections by both H5N1 and H9N2 AI viruses. Egypt is regarded as a hot spot of AI virus evolution. Although no natural reassortant of H5N1 and H9N2 AI viruses has been reported so far, their cocirculation in Egypt may allow emergence of reassortants that may present a significant public health risk. Using reverse genetics, we report here the first comprehensive data showi… Show more

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Cited by 30 publications
(39 citation statements)
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“…A(H5N1)/ A(H9N2) reassortants have been detected in other countries where these viruses cocirculate, suggesting that there is not complete incompatibility between their gene segments (Monne et al 2013;Marinova-Petkova et al 2016). Lack of detection of reassortant viruses in Egypt may also be due to lack of sensitivity of current surveillance measures for identifying such viruses or an associated fitness defect Naguib et al 2017;Arai et al 2019). Although no A(H5N1)/A(H9N2) reassortants have been described, a novel A(H5N8)/A(H5N1) reassortant has been detected in a duck.…”
Section: Reassortment Of Hpaiv H5nx In Egyptmentioning
confidence: 99%
“…A(H5N1)/ A(H9N2) reassortants have been detected in other countries where these viruses cocirculate, suggesting that there is not complete incompatibility between their gene segments (Monne et al 2013;Marinova-Petkova et al 2016). Lack of detection of reassortant viruses in Egypt may also be due to lack of sensitivity of current surveillance measures for identifying such viruses or an associated fitness defect Naguib et al 2017;Arai et al 2019). Although no A(H5N1)/A(H9N2) reassortants have been described, a novel A(H5N8)/A(H5N1) reassortant has been detected in a duck.…”
Section: Reassortment Of Hpaiv H5nx In Egyptmentioning
confidence: 99%
“…Human influenza virus HAs preferentially bind the ␣2,6-linked sialylglycans (␣2,6 Sia) that are abundant in human upper airway epithelia, whereas AI virus HAs preferentially bind the ␣2,3-linked sialylglycans (␣2,3 Sia) in bird intestinal epithelia (17). Several AI viruses, including H9N2 G1 lineage viruses, have a relatively high ␣2,6 Sia binding affinity (18)(19)(20)(21)(22)(23), which may facilitate the bird-to-human transmission of AI viruses.…”
mentioning
confidence: 99%
“…However, it is interestingly that not all clones could infect ASK cells, which suggests a stochastic recombination mechanism. Given that some segments may be incompatible in a determined gene constellation (in our case HPR7b) (Arai, 2019), we propose that the segments 6 of all genotypes used in this work are compatible with an HPR7b gene constellation, including when segment 6 is an HPR0 genotype. However, it is important to note that all the synthetic reassortant viruses have the 5’ and 3’ UTR from the virulent ISAV 752_09 strain (HPR7b genotype) this is relevant due to the UTR ends variation between ISAV strains that have been described (Fourrier, Heuster, Munro, & Snow, 2011).…”
Section: Discussionmentioning
confidence: 99%