Genetic Control of enzyme synthesis

Halvorson, Harlyn O.

doi:10.1002/jez.1401570111

Cited by 7 publications

(3 citation statements)

References 58 publications

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“…Their only effect is to increase the differential rate of enzyme synthesis during a limited period of the cell cycle. These results may explain the well-known phenomenon in yeast where, under conditions of full induction or derepression, the maximal level of a given enzyme comprises only a fraction of a per cent of the total cell protein (6). This is in marked contrast to the situation found in bacterial cells.…”

Section: Discussionmentioning

confidence: 68%

Effect of Gene Position on the Timing of Enzyme Synthesis in Synchronous Cultures of Yeast

Tauro

Halvorson

1966

J Bacteriol

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, AND HARLYN 0. HALVORSON. Effect of gene position on the timing of enzyme synthesis in synchronous cultures of yeast. J. Bacteriol. 92:652-661.-In synchronously growing cultures of Saccharomyces cerevisiae, enzyme synthesis is periodic. The effect of various factors on the timing of a-glucosidase synthesis has been investigated. The period of the cell cycle during which ac-glucosidase is synthesized is unaffected by the method employed to induce synchrony, as well as other environmental conditions. However, a definite relationship exists between the number of nonallelic structural genes present for a-glucosidase and the number of periods of synthesis during the cell cycle. It is concluded that the periodic synthesis of enzymes observed in synchronously growing cultures of yeast is probably the result of an ordered process of transcription of the various structural genes.

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Section: Discussionmentioning

confidence: 68%

Effect of Gene Position on the Timing of Enzyme Synthesis in Synchronous Cultures of Yeast

Tauro

Halvorson

1966

J Bacteriol

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“…In yeast, net synthesis of two genetically distinguishable /~-glucosidases occurs at two characteristic periods during each repetition of the cell cycle (11). In hybrids, each enzyme is synthesized at its characteristic time.…”

Section: Histone and Dnamentioning

confidence: 99%

“…The ability of cells to express specific portions of their genome in a systematic way appears to be inherited with the genome itself. In yeast, net synthesis of two genetically distinguishable /~glucosidases occurs at two characteristic periods during each repetition of the cell cycle (11). In hybrids, each enzyme is synthesized at its characteristic time.…”

Section: Histone and Dnamentioning

confidence: 99%

SIMULTANEOUS SYNTHESIS OF HISTONE AND DNA IN SYNCHRONOUSLY DIVIDING TETRAHYMENA PYRIFORMIS

Hardin

Einem

Lindsay

1967

The Journal of Cell Biology

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Histone and DNA syntheses have been studied in synchronously dividing Tetrahymena pyriformis GL. During the heat treatment necessary to synchronize cultures of this amicronucleate protozoan, the DNA content of the already polyploid macronucleus increases. When the cells begin synchronous division, their DNA content is reduced in a stepwise process which is closely paralleled by reduction of macronuclear histone content. During cell division, the contents of DNA and histone decrease by slightly more than twofold, and in the subsequent S phase, DNA and histone increase simultaneously to 85 % of the values expected if all chromosomes were to double. The first step in the process of reduction of DNA and histone contents is their decrease in excess of twofold, and this is accomplished by removal of extrusion bodies from the nuclei of dividing cells. The second step is a mechanism which allows, in effect, only 70 % of the chromatin in the average nucleus to duplicate. Such partial duplication suggests that both histone and DNA syntheses in synchronous Tetrahymena depend upon a regulatory mechanism, the mediating elements of which are localized in only certain chromosomes.

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Synchronous cultures in cytodifferentiation studies

Neff

1971

In Vitro

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Genetic Control of enzyme synthesis

Cited by 7 publications

References 58 publications

Effect of Gene Position on the Timing of Enzyme Synthesis in Synchronous Cultures of Yeast

Effect of Gene Position on the Timing of Enzyme Synthesis in Synchronous Cultures of Yeast

SIMULTANEOUS SYNTHESIS OF HISTONE AND DNA IN SYNCHRONOUSLY DIVIDING TETRAHYMENA PYRIFORMIS

Synchronous cultures in cytodifferentiation studies

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