Genetic control of epidermis differentiation in Drosophila.

Payre, François

doi:10.1387/ijdb.15272387

Cited by 80 publications

(44 citation statements)

References 109 publications

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“…After the secretion (stage 16) and assembly (stage 17) of the wild-type cuticle it functions as a nonpermeable barrier for antibodies (29). TEM analysis revealed that indeed all layers of the DmMANF ⌬96mz mutant cuticle were disorganized (Fig.…”

Section: Embryos Lacking Both Maternal and Zygotic Dmmanf Results In Cmentioning

confidence: 99%

Evidence that DmMANF is an invertebrate neurotrophic factor supporting dopaminergic neurons

Palgi

Lindström

Peränen

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

129

214

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In vertebrates the development and function of the nervous system is regulated by neurotrophic factors (NTFs). Despite extensive searches no neurotrophic factors have been found in invertebrates. However, cell ablation studies in Drosophila suggest trophic interaction between neurons and glia. Here we report the invertebrate neurotrophic factor in Drosophila, DmMANF, homologous to mammalian MANF and CDNF. DmMANF is expressed in glia and essential for maintenance of dopamine positive neurites and dopamine levels. The abolishment of both maternal and zygotic DmMANF leads to the degeneration of axonal bundles in the embryonic central nervous system and subsequent nonapoptotic cell death. The rescue experiments confirm DmMANF as a functional ortholog of the human MANF gene thus opening the window for comparative studies of this protein family with potential for the treatment of Parkinson's disease.development ͉ dopamine ͉ Drosophila ͉ glia ͉ neurite

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Section: Embryos Lacking Both Maternal and Zygotic Dmmanf Results In Cmentioning

confidence: 99%

Evidence that DmMANF is an invertebrate neurotrophic factor supporting dopaminergic neurons

Palgi

Lindström

Peränen

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

129

214

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“…Furthermore, none of the encoded collagens closely resembles the worm cuticle forms. The Drosophila cuticle is a stratified structure comprising an envelope layer, a proteinaceous epicuticle, and a procuticle rich in chitin (polymer of Nacetylglucosamine) (11). The envelope functions as a support for subsequent cuticle deposition, and the epicuticle and the procuticle together stiffen the exoskeleton.…”

mentioning

confidence: 99%

Mutation of TweedleD, a member of an unconventional cuticle protein family, alters body shape in Drosophila

Guan

Middlebrooks

Alexander

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

124

155

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Body shape determination represents a critical aspect of morphogenesis. In the course of investigating body shape regulation in Drosophila, we have identified a dominant mutation, TweedleD 1 (TwdlD 1 ), that alters overall dimensions at the larval and pupal stages. Characterization of the affected locus led to the discovery of a gene family that has 27 members in Drosophila and is found only among insects. Analysis of gene expression at the RNA and protein levels revealed gene-specific temporal and spatial patterns in ectodermally derived tissues. In addition, light microscopic studies of fluorescently tagged proteins demonstrated that Tweedle proteins are incorporated into larval cuticular structures. This demonstration that a mutation in a Drosophila cuticular protein gene alters overall morphology confirms a role for the fly exoskeleton in determining body shape. Furthermore, parallels between these findings and studies of cuticle collagen genes in Caenorhabditis elegans suggest that the exoskeleton influences body shape in diverse organisms.arthropod ͉ morphogenesis ͉ tandem duplication ͉ Tubby

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“…The metabolic state and gene expression in these cells directed or regulated by the nutrient dependence and environmental effect are coordinated toward this fate for cells, and imprint onto the subsequent organogenesis. During organogenesis, the cells of embryonic ectoderm give rise to neural progenitors in the dorsal side and epidermal progenitors in the ventral side in vertebrates [16], while also give rise to neural cells [17] and epidermal cuticle in Drosophila [18]. In this regard, the regulation of both cell state and gene classes in ectoderm with proposed nutrient gradient during gastrulation fits with the developmental outcome of phenotype, also supporting the rationality of the theory.…”

Section: Phenotypic Fates Of Three Germ Layers In Gastrulamentioning

confidence: 58%

“…The endoderm is destined to differentiate into the epithelial lining of digestive tract, associated glands and respiratory system in both vertebrates [14] and Drosophila [15]. The ectoderm is destined to differentiate into the neural progenitors and epidermal progenitors in vertebrates [16], and to neural cells [17] and epidermal cuticle in Drosophila [18]. The mesoderm is destined to differentiate into the bones, muscles [19], and adipose tissues [20] in vertebrates, and to muscles in Drosophila [21].…”

Section: Nutrient Preserving the Trilaminar Fates In Gastrula Versus mentioning

confidence: 99%

Regulation of Both Cell State and Gene Expression with Nutrient Gradient as Conserved Mechanism Differentiating the Cell Fates for Embryonic Gastrulation: A Theory

Cai¹

2016

OALib

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In this article, it is newly suggested the regulation from nutrient gradient on both cell metabolic state and expressional gene classes as the conserved mechanism differentiating the cell fates for formation of the three germ layers of gastrula in animals. As a new theory, it is supported by the totipotency and pluripotency of early embryonic cells and cultured stem cells to be regulated by nutrients, as well as by the universal formation of nutrient gradient during gastrulation in various animals. Besides, it is also supported by the subsequent phenotypic fates of three germ layers of gastrula, with the endoderm manifesting expression of gene classes in nutritious condition and giving rise to the epithelium of digestive and respiratory system; the ectoderm manifesting expression of gene classes with nutrient dependence and environmental effect, and giving rise to the nervous and epithelial tissues; the mesoderm lying between them and giving rise to the muscle and adipose. Likewise, it is directly supported by the different nutrient effects onto such trilaminar differentiation in various cultured stem cells. Finally, it is in further supported by the evolutionary effects of nutrients in preserving the trilaminar fates in gastrula versus relative permitting the variations in anteroposterior determination. Conclusively, it is identified the nutrient gradient as an important mechanism to partially differentiate the cell fates for embryonic gastrulation.

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Genetic control of epidermis differentiation in Drosophila.

Cited by 80 publications

References 109 publications

Evidence that DmMANF is an invertebrate neurotrophic factor supporting dopaminergic neurons

Evidence that DmMANF is an invertebrate neurotrophic factor supporting dopaminergic neurons

Mutation of TweedleD, a member of an unconventional cuticle protein family, alters body shape in Drosophila

Regulation of Both Cell State and Gene Expression with Nutrient Gradient as Conserved Mechanism Differentiating the Cell Fates for Embryonic Gastrulation: A Theory

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