Genetic Control of Ovarian Development

Tevosian, Sergei G.

doi:10.1159/000339511

Cited by 21 publications

(22 citation statements)

References 280 publications

(180 reference statements)

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“…These include critical female-pathway genes, such as foxl2 and genes in the Rspo1/Wnt/β-catenin signaling pathway known to regulate ovarian differentiation in mammals (31,32). Wnt4 (wingless-type MMTV integration site family, member 4), which activates Ctnnb1 (β-catenin) and Fst (follistatin) to maintain mammalian ovarian development (33) (Fig. 3A), is duplicated in the bluehead wrasse: wnt4a was downregulated early along with cyp19a1a, consistent with a conserved feminizing role, while its paralogue wnt4b was sharply upregulated in late sex change and is expressed only in mature testes ( Fig.…”

Section: Neofunctionalization Of Ovary-promoting Genes and New Genetimentioning

confidence: 99%

Stress, novel sex genes and epigenetic reprogramming orchestrate socially-controlled sex change

Todd

Ortega‐Recalde

Liu

et al. 2018

Preprint

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Bluehead wrasses undergo dramatic, socially-cued female to male sex change. We apply transcriptomic and methylome approaches in this wild coral reef fish to identify the primary trigger and subsequent molecular cascade of gonadal metamorphosis.Our data suggest that the environmental stimulus is exerted via the stress axis, that repression of the aromatase gene (encoding the enzyme converting androgens to estrogens) triggers a cascaded collapse of feminizing gene expression, and identifies notable sex-specific gene 2 neofunctionalization. Furthermore, sex change involves distinct epigenetic reprogramming and an intermediate state with altered epigenetic machinery expression akin to the early developmental cells of mammals. These findings reveal at a molecular level how a normally committed developmental process remains plastic and is reversed to completely alter organ structures.

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Section: Neofunctionalization Of Ovary-promoting Genes and New Genetimentioning

confidence: 99%

Stress, novel sex genes and epigenetic reprogramming orchestrate socially-controlled sex change

Todd

Ortega‐Recalde

Liu

et al. 2018

Preprint

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“…Additional contributions of other genes from the SOX family [e.g., SOX3 and SOX10) has also been evidenced [41,49] from the study of DSD conditions. Acting through its receptor (FGFR2), Fgf9 suppresses the Wnt4 signaling pathway, inhibiting the mechanism that controls the ovarian differentiation [40,44,45,50]. Moreover, Fgf9 sustains SOX9 expression through a positive feedback loop [34].…”

Section: The Determination Of the Normal Gonadal Patternmentioning

confidence: 99%

Disturbed Ovarian Differentiation in XX;SRY-Negative Dogs

Payan-Carreira¹

2018

obm genet

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In a mammal, at the beginning of its development, the gonad is bipotential. The shift into a male or female pathway is coordinated by the sex chromosomal complement, which triggers a series of genetic pathways signaling the developmental pattern of the gonadal anlage. Being mutually exclusive, the differentiated gonad should be either a testis or an ovary. In females, the absence of SRY, a testis-determining gene, drives the signaling cascades controlling the ovarian differentiation. Albeit rare, disorders of the gonadal differentiation may occur in men and domestic animals and may cause infertility or sterility. In dogs, the XX;SRY-negative disorder of sexual development (DSD) is the most frequent condition. The disorder typically presents a wide spectrum of developmental conditions of the gonad and variable virilization of the genital phenotype, that may be accompanied by hypospadias. This condition may be inherited as a sex-limited autosomal recessive trait; however, the mechanism explaining its occurrence remains poorly understood. This review intends to present an overview of the morphologic features of XX;SRY-negative syndrome in dogs, while addressing the current knowledge regarding the genetic mechanism underlying this condition.

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“…This is a major determinant of ovarian fate in mammals and is regulated via complex feedback interactions that include Wnt4 and Rspo1 [Zaytouni et al, 2011;Tevosian, 2013]. In the chicken, as in the mouse, these 2 molecules are upregulated in females at the time of gonadal differentiation, suggesting a conserved role in ovarian differentiation.…”

Section: Molecular Asymmetrymentioning

confidence: 99%

“…In the mouse, FOXL2 is only required after birth, whereas in some other mammals (e.g. goat) it is also essential for female sex determination [DeFalco and Capel, 2009;Veitia, 2010;Cutting et al, 2013;Sekido and Lovell-Badge, 2013;Tevosian, 2013].…”

Section: L:r Asymmetry and Sex (Gonadal) Determinationmentioning

confidence: 99%

Gonadal Asymmetry and Sex Determination in Birds

Guioli¹,

Nandi

Zhao

et al. 2014

Sex Dev

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Although vertebrates display a superficial bilateral symmetry, most internal organs develop and locate with a consistent left:right asymmetry. There is still considerable debate as to when this process actually begins, but it seems that, at least for some species, the initial steps occur at a very early stage of development. In recent years, a number of model systems, including the chick embryo, have been utilised to increase our understanding of the molecular basis of this complex developmental process. While the basic elements of asymmetry are clearly conserved in chick development, the chick embryo also exhibits an additional unusual asymmetry in terms of the development of the gonads. In the female chick embryo, only 1 gonad and accessory structures fully develop, with the result that the adult hen has only 1 ovary and a single oviduct - both on the left side. With a small number of exceptions, this is a consistent feature of avian development. Here, we describe the morphological development and molecular basis of this unusual asymmetry, consider the implications for avian sex determination, and discuss the possible biological reasons why many birds have adopted a single-ovary system.

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Genetic Control of Ovarian Development

Cited by 21 publications

References 280 publications

Stress, novel sex genes and epigenetic reprogramming orchestrate socially-controlled sex change

Stress, novel sex genes and epigenetic reprogramming orchestrate socially-controlled sex change

Disturbed Ovarian Differentiation in XX;SRY-Negative Dogs

Gonadal Asymmetry and Sex Determination in Birds

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