“…It represents autoimmune uveitis in humans, which is a group of diseases affecting the eye and estimated to be responsible for 10% of the cases of severe visual handicap that show associations with major histocompatibility complex (MHC) class I or class II molecules, 15 and MHC-restricted presentation of uveitogenic antigens has been demonstrated to be a key event in the pathogenesis of uveitis in humans 16 and in animal models. 17 As in clinical uveitis, susceptibility to EAU is genetically controlled, and the responsiveness to EAU induction is determined by the effect of genes belonging to the MHC, H2 in mouse, and other non-MHC genes. 15 MHC gene control is determined largely by epitope recognition, and in mouse some H2 haplotypes, if present on the appropriate background, are conducive to disease induction.…”