Genetic damage induced by CrO3 can be reduced by low doses of Protoporphyrin-IX in somatic cells of Drosophila melanogaster

Vidal, Matilde; Pimentel, P Emilio; Sanchez, Carlota

doi:10.1016/j.toxrep.2014.10.007

Cited by 4 publications

(1 citation statement)

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“…These effects found in insects [ 19 ] are reminiscent of the control of TSPO on apoptosis, life span, and neurodegeneration in mammals [ 11 , 21 , 78 ]. Interestingly, PPIX can also enhance the lifespan of Drosophila , both female and male [ 79 , 80 ]. Data regarding Drosophila reported by Curtis et al [ 81 ] suggest that upregulation of the mitochondrial antioxidant manganese superoxide dismutase (Mn-SOD) and a retrograde signal of ROS from the mitochondria can serve as intermediate steps in life span extension of Drosophila .…”

Section: Tetrapyrroles Including Protoporphyrins Such As Ppix Asmentioning

confidence: 99%

Tetrapyrroles as Endogenous TSPO Ligands in Eukaryotes and Prokaryotes: Comparisons with Synthetic Ligands

Veenman

Vainshtein

Yasin

et al. 2016

IJMS

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The 18 kDa translocator protein (TSPO) is highly 0conserved in eukaryotes and prokaryotes. Since its discovery in 1977, numerous studies established the TSPO’s importance for life essential functions. For these studies, synthetic TSPO ligands typically are applied. Tetrapyrroles present endogenous ligands for the TSPO. Tetrapyrroles are also evolutionarily conserved and regulate multiple functions. TSPO and tetrapyrroles regulate each other. In animals TSPO-tetrapyrrole interactions range from effects on embryonic development to metabolism, programmed cell death, response to stress, injury and disease, and even to life span extension. In animals TSPOs are primarily located in mitochondria. In plants TSPOs are also present in plastids, the nuclear fraction, the endoplasmic reticulum, and Golgi stacks. This may contribute to translocation of tetrapyrrole intermediates across organelles’ membranes. As in animals, plant TSPO binds heme and protoporphyrin IX. TSPO-tetrapyrrole interactions in plants appear to relate to development as well as stress conditions, including salt tolerance, abscisic acid-induced stress, reactive oxygen species homeostasis, and finally cell death regulation. In bacteria, TSPO is important for switching from aerobic to anaerobic metabolism, including the regulation of photosynthesis. As in mitochondria, in bacteria TSPO is located in the outer membrane. TSPO-tetrapyrrole interactions may be part of the establishment of the bacterial-eukaryote relationships, i.e., mitochondrial-eukaryote and plastid-plant endosymbiotic relationships.

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