Genetic deletion and pharmacologic inhibition of E3 ubiquitin ligase HOIP impairs the propagation of myeloid leukemia

Jimbo, Koji; Hattori, Ayuna; Koide, Shuhei; Ito, Takahiro; Sasaki, Katsuhiro; Iwaï, Kazuhiro; Nannya, Yasuhito; Iwama, Atsushi; Tojo, Arinobu; Konuma, Takaaki

doi:10.1038/s41375-022-01750-7

Cited by 4 publications

(4 citation statements)

References 53 publications

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“…LUBAC inhibited the expression of NR6A1 by promoting its linear ubiquitination, thereby dephosphorylating RIPK3 and consequently inhibiting the vascular smooth muscle cell (VSMC) apoptosis [ 66 ]. Genetic deletion and pharmacologic inhibition of E3 ubiquitin ligase HOIP impairs the propagation of myeloid leukemia [ 67 ]. Above all, the linear ubiquitination mediated cell apoptosis mostly is regulated by NEMO/NF-κB signaling pathway or its related regulation factors which comes to TNFR, TLR, and NOD signaling pathways.…”

Section: Regulation Of Apoptosis By Linear Ubiquitinationmentioning

confidence: 99%

The mechanism of linear ubiquitination in regulating cell death and correlative diseases

Gao,

Zhang,

Shi

et al. 2023

Cell Death Dis

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Linear ubiquitination is a specific post-translational modification in which ubiquitin is linked through M1 residue to form multiple types of polyubiquitin chains on substrates in order to regulate cellular processes. LUBAC comprised by HOIP, HOIL-1L, and SHARPIN as a sole E3 ligase catalyzes the generation of linear ubiquitin chains, and it is simultaneously adjusted by deubiquitinases such as OTULIN and CYLD. Several studies have shown that gene mutation of linear ubiquitination in mice accompanied by different modalities of cell death would develop relative diseases. Cell death is a fundamental physiological process and responsible for embryonic development, organ maintenance, and immunity response. Therefore, it is worth speculating that linear ubiquitin mediated signaling pathway would participate in different diseases. The relative literature search was done from core collection of electronic databases such as Web of Science, PubMed, and Google Scholar using keywords about main regulators of linear ubiquitination pathway. Here, we summarize the regulatory mechanism of linear ubiquitination on cellular signaling pathway in cells with apoptosis, necroptosis, autophagy, pyroptosis, and ferroptosis. Intervening generation of linear ubiquitin chains in relative signaling pathway to regulate cell death might provide novel therapeutic insights for various human diseases.

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Section: Regulation Of Apoptosis By Linear Ubiquitinationmentioning

confidence: 99%

The mechanism of linear ubiquitination in regulating cell death and correlative diseases

Gao,

Zhang,

Shi

et al. 2023

Cell Death Dis

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Section: Introductionmentioning

confidence: 99%

“…Mouse knockout models suggest that LUBAC is required for fetal and adult hematopoiesis [ 109 ]. A recent mouse study found that HOIP is essential for myeloid leukemia propagation and maintenance [ 109 ]. The study utilized aggressive murine myeloid leukemia models driven by retroviral transduction of oncogenes: MLL-AF9 and NRAS G12V-driven acute myeloid leukemia (AML) and BCR-ABL and NUP98-HOXA9-driven blast crisis of chronic myelogenous leukemia (CML-BC) models.…”

Section: Introductionmentioning

confidence: 99%

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Mechanisms underlying linear ubiquitination and implications in tumorigenesis and drug discovery

Li,

Liu,

2023

Cell Commun Signal

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Linear ubiquitination is a distinct type of ubiquitination that involves attaching a head-to-tail polyubiquitin chain to a substrate protein. Early studies found that linear ubiquitin chains are essential for the TNFα- and IL-1-mediated NF-κB signaling pathways. However, recent studies have discovered at least sixteen linear ubiquitination substrates, which exhibit a broader activity than expected and mediate many other signaling pathways beyond NF-κB signaling. Dysregulation of linear ubiquitination in these pathways has been linked to many types of cancers, such as lymphoma, liver cancer, and breast cancer. Since the discovery of linear ubiquitin, extensive effort has been made to delineate the molecular mechanisms of how dysregulation of linear ubiquitination causes tumorigenesis and cancer development. In this review, we highlight newly discovered linear ubiquitination-mediated signaling pathways, recent advances in the role of linear ubiquitin in different types of cancers, and the development of linear ubiquitin inhibitors.

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LUBAC-mediated linear ubiquitination in tissue homeostasis and disease

Sasaki

Iwaï

2023

The Journal of Biochemistry

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In addition to its role in the ubiquitin-proteasome system of protein degradation, polyubiquitination is involved in the regulation of intracellular events. Depending on the type of ubiquitin-ubiquitin linkage used, polyubiquitin can assume several types of structures. The spatio-temporal dynamics of polyubiquitin involve multiple adaptor proteins and induce different downstream outputs. Linear ubiquitination, in which the N-terminal methionine on the acceptor ubiquitin serves as the site for ubiquitin-ubiquitin conjugation, is a rare and atypical type of polyubiquitin modification. The production of linear ubiquitin chains is dependent on various external inflammatory stimuli and leads to the transient activation of the downstream NF-κB signaling pathway. This in turn suppresses extrinsic programmed cell death signals and protects cells from activation-induced cell death under inflammatory conditions. Recent evidence has revealed the role of linear ubiquitination in various biological processes under both physiological and pathological conditions. This led us to propose that linear ubiquitination may be pivotal in the “inflammatory adaptation” of cells, and consequently in tissue homeostasis and inflammatory disease. In this review, we focused on the physiological and pathophysiological roles of linear ubiquitination in vivo in response to a changing inflammatory microenvironment.

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Genetic deletion and pharmacologic inhibition of E3 ubiquitin ligase HOIP impairs the propagation of myeloid leukemia

Cited by 4 publications

References 53 publications

The mechanism of linear ubiquitination in regulating cell death and correlative diseases

The mechanism of linear ubiquitination in regulating cell death and correlative diseases

Mechanisms underlying linear ubiquitination and implications in tumorigenesis and drug discovery

LUBAC-mediated linear ubiquitination in tissue homeostasis and disease

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