1995
DOI: 10.1291/hypres.18.supplementi_s1
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Genetic Determinants of Dopaminergic Activity: Potential Role in Blood Pressure Regulation

Abstract: Dopamine (DA) availability for precursor function and peripheral biological action is dependent on synthesis and inactivation enzymes, most of them have been cloned and located. An aromatic acid decarboxylase (AADC) defect has been reported in male homozygotic twins. The syndrome of complete dopamine-i9-hydroxylase deficiency with orthostatic hypotension and very high DA contributes to our understanding of the role of DA as a catecholamine with a peripheral biological action of its own. Xlinked isolated monoam… Show more

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Cited by 9 publications
(3 citation statements)
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“…61 Since phenolsulfotransferase activity and sulfate availability are limit-ing factors in sulfoconjugation, it is conceivable that the high affinity DA sulfoconjugation occurs at the expense of the lower affinity NA and A conjugation and affect the biological impact of both antagonistic systems; low sulfoconjugation may increase the availability of free NA and A and their prohypertensive action whereas high sulfoconjugation decreases the free DA availability and its antihypertensive action. 62 An alternative explanation of an altered dopamine NA relationship in hypertensives is that a defective dopaminergic control in the central nervous system 63 yields excessive central and peripheral noradrenergic discharge.…”
Section: Dopamine In Essential Hypertensionmentioning
confidence: 99%
See 1 more Smart Citation
“…61 Since phenolsulfotransferase activity and sulfate availability are limit-ing factors in sulfoconjugation, it is conceivable that the high affinity DA sulfoconjugation occurs at the expense of the lower affinity NA and A conjugation and affect the biological impact of both antagonistic systems; low sulfoconjugation may increase the availability of free NA and A and their prohypertensive action whereas high sulfoconjugation decreases the free DA availability and its antihypertensive action. 62 An alternative explanation of an altered dopamine NA relationship in hypertensives is that a defective dopaminergic control in the central nervous system 63 yields excessive central and peripheral noradrenergic discharge.…”
Section: Dopamine In Essential Hypertensionmentioning
confidence: 99%
“…Sympathoneuronal imaging by 6-(18F) fluorodopamine, confirming extraneuronal sulfoconjugation of DA 95 is a promising approach in the brain but not yet tested in the periphery. Several enzymes involved in DA synthesis metabolism and action and their recognised abnormalities 62 make DA synthesis, metabolism and action candidates for enzyme targeting. 96 Increased density of peripheral mononuclear cell D3 receptor progressing with human diastolic hypertension 97 may represent an upregulation mechanism consequent to the progressively decreasing dopaminergic function with evolution of hypertension.…”
Section: Diagnostic and Therapeutic Implicationsmentioning
confidence: 99%
“…23 Dopamine has been implicated as an important factor in BP regulation. 24,25 The Met/Met genotype of the Val158Met COMT variant produces a protein with reduced COMT activity compared with that encoded by the Val/Val genotype. 26 A few studies have assessed the relationship of the COMT Val158Met variant to BP elevation in adults; however, the findings are conflicting.…”
Section: Introductionmentioning
confidence: 99%