Genetic, dietary, and other lifestyle determinants of serum homocysteine levels in young adults in Costa Rica

Schumacher, Ileana Holst; Rojas, Rafael Monge; Gutiérrez, Priscilla Cambronero; Camacho, Gilbert Brenes

doi:10.1590/s1020-49892005000400007

Cited by 10 publications

(7 citation statements)

References 30 publications

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“…Among all 40 studies, 3 studies included populations who were prescreened for genotype (CC or TT) (36,38,39), 2 studies were conducted in populations with a low prevalence of the T allele and thus had no women with TT genotype (40,41), and 3 studies were conducted in population groups with an MTHFR C677T genotype distribution that was significantly different from expected (HWE P value ,0.05) (42)(43)(44).…”

Section: Study Characteristicsmentioning

confidence: 99%

Assessing the association between the methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphism and blood folate concentrations: a systematic review and meta-analysis of trials and observational studies

Tsang

Devine

Cordero

et al. 2015

The American Journal of Clinical Nutrition

119

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Section: Study Characteristicsmentioning

confidence: 99%

Assessing the association between the methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphism and blood folate concentrations: a systematic review and meta-analysis of trials and observational studies

Tsang

Devine

Cordero

et al. 2015

The American Journal of Clinical Nutrition

119

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“…The prevalence of HHcy was 13.4% for males and 3.3% in females, and these findings were comparable to those from previous reports on the Korean population [ 38 ]. The incidence of HHcy varies around the world, with the lowest prevalence in the United States (5%), 6% in Costa Rica, 27.5% in China, and the highest prevalence in India (77%) [ 39 , 40 , 41 ]. As shown in Table 1 , two of the HHcy groups had a higher prevalence of binge drinking, regardless of the presence of MetS.…”

Section: Discussionmentioning

confidence: 99%

Hyperhomocysteinemia Concurrent with Metabolic Syndrome Is Independently Associated with Chronic Kidney Disease among Community-Dwelling Adults in an Urban Korean Population

Moon

Kim

2020

IJERPH

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Elevated homocysteine (Hcy) levels and metabolic syndrome (MetS) are associated with chronic kidney disease (CKD). We investigated the combined effects of hyperhomocysteinemia (HHcy) and MetS on CKD among community-dwelling adults in an urban area of South Korea. We also identified the combination of HHcy and individual MetS components associated with the maximal risk of CKD. A retrospective cross-sectional study involving 19,311 health examinees between 2 January 2011 and 31 December 2015 was conducted. The participants were divided into four groups—namely, the HHcy−/MetS−, HHcy−/MetS+, HHcy+/MetS−, and HHcy+/MetS+ groups. CKD was defined as a low eGFR <60 mL/min/1.73 m2 or albuminuria. The HHcy+/MetS+ group had a higher risk of CKD than the HHcy−/MetS+ group (odds ratio (OR): 1.750, p = 0.002 for males; OR: 3.224, p < 0.001 for females). The HHcy+/MetS+ group had a higher CKD risk than the HHcy+/MetS− group; however, the difference was not statistically significant (OR: 1.070, p = 0.712 for males; OR: 1.847, and p < 0.074 for females). HHcy concurrent with MetS increased the CKD risk. Among the combinations of HHcy and MetS components, the coexistence of HHcy and central obesity had the greatest effect on CKD. Therefore, the timely detection and treatment of HHcy and MetS are important for preventing CKD.

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“…The RBC folate status has increased significantly in populations where the mandatory fortification with FA has been implemented [65][66][67][68]. The RBC folate status has increased significantly in populations where the mandatory fortification with FA has been implemented [65][66][67][68].…”

Section: How Muchmentioning

confidence: 99%

“…Fortified food is a good an alternative. The RBC folate status has increased significantly in populations where the mandatory fortification with FA has been implemented [65][66][67][68]. The most recent survey performed in Canada [69], a typical country with mandatory fortification and significant decrease of NTDs, shows that the median RBC folate concentration of women in childbearing age (15-45 years) in 2007-2009 was 1,193 nmol/L, although 22% of them were still below the optimal level (<906 nmol/L).…”

Section: How the More Folate Or Folic Acid Should Be Assumed?mentioning

confidence: 99%

More folic acid, the five questions: Why, who, when, how much, and how

Mastroiacovo¹,

Leoncini²

2011

BioFactors

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In recent years, a number of studies have been performed to evaluate the possible health benefits of an increased intake of folic acid (FA) on human health. However, the only well-documented benefit emerging from randomized controlled trials, nonrandomized interventions trials, and observational studies is the risk reduction of neural tube defects (NTDs). NTDs are congenital malformations that include anencephaly, encephalocele, and spina bifida caused by the failure of fusion of the neural tube that normally closes between 22nd and 28th day since conception (on an average 40-42th day after the first day of last menstrual period). The occurrence of NTDs varies among population between 0.8 and 3 per 1,000, and it is estimated that 324,000 pregnancies are affected every year worldwide. More FA can decrease the NTDs risk up to 0.6 per 1,000 births. Other malformations as congenital heart defects, cleft lip, and limb deficiencies can be most probably also reduced. To decrease the NTDs risk, it is recommended that all women capable of becoming pregnant should have more FA. The goal is that every woman could start her pregnancy with an optimal folate status, estimated today to be as more than 906 nmol/L of red blood cell folate concentration. More FA can be obtained through a strict Mediterranean pattern of nutrition and healthy life style, fortified food, supplements. Women and health authorities can choose the most appropriate strategy. Monitoring folate status of women during the periconceptional period is an essential way to evaluate the success of the preferred strategy.

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Genetic, dietary, and other lifestyle determinants of serum homocysteine levels in young adults in Costa Rica

Abstract: Only serum vitamin B(12) levels and the genotype TT of the enzyme MTHFR were considered significant predictors of high serum tHcy levels in the Costa Rica population studied.

Cited by 10 publications

References 30 publications

Assessing the association between the methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphism and blood folate concentrations: a systematic review and meta-analysis of trials and observational studies

Assessing the association between the methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphism and blood folate concentrations: a systematic review and meta-analysis of trials and observational studies

Hyperhomocysteinemia Concurrent with Metabolic Syndrome Is Independently Associated with Chronic Kidney Disease among Community-Dwelling Adults in an Urban Korean Population

More folic acid, the five questions: Why, who, when, how much, and how

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