This paper presents a current view of the genomic and neuroendocrine interaction based on our studies of the reproductive system in the platyfish (Xiphophorus maculatus). It also presents observations from basic research and applied biologists on natural and artificially reared fishes and indicates that there is a direct genetic involvement in the control of spawning, growth rates, size and age at maturation and final body size, similar to that described in platyfish. The past, present and future association of aquaculture and basic science, especially DNA technology, is discussed and potential directions for future research are presented.