Genetic Disposition: Susceptibility of Human Blood Groups and Abo Analysis to Malaria and Typhoid Infections

Abstract

Background: Malaria and typhoid have remained major infectious tropical diseases. Clinically, whenever there is severe malaria, cough is always an associating symptom owing to typhoid infection arising from poor hygiene in respect to drinking water and food. There is a strong association between human blood group and disease. Residual malaria transmission, effect of climate change on malaria vector composition, environmental management targeted at malaria breeding control as an intervention strategy are areas of interest to WHO in malaria control in Sub-saharan Africa. A body of data is been built on susceptibility of human blood groups to malaria, HIV and HBV and presently malaria and typhoid. If climate change warrants a change in composition of vectors and as well resistance to ACT therapy, the susceptibility or vulnerability of the human blood group is also called to question. The link between susceptibility of human blood group to malaria and typhoid has not been previously investigated. Purpose: The present study assesses the genetic disposition (susceptibility of human blood groups and abo analysis) to malaria and typhoid infections. Patients and Methods: One hundred (100) pa-