2014
DOI: 10.1007/s00606-014-1040-x
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Genetic diversity and taxol content variation in the Chinese yew Taxus mairei

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Cited by 6 publications
(2 citation statements)
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“…Taxus plants are well-known by their ornamental values, cancer-inhibitory alkaloid paclitaxel (Taxol), and timber uses (Xi et al 2014 ). As an effective curing cancer of chemical compounds for 50 years (Foa et al 1994 ; Bi et al 2014 ), the same difficulties with other supply of active compounds: limited quantity of active compounds in tissues, low growth rate, limited localization of active ingredients in the specific organs, and destruction of the nature resource (Kazmi et al 1991 ; Frense 2007 ; Hussain et al 2013 ).…”
Section: Introductionmentioning
confidence: 99%
“…Taxus plants are well-known by their ornamental values, cancer-inhibitory alkaloid paclitaxel (Taxol), and timber uses (Xi et al 2014 ). As an effective curing cancer of chemical compounds for 50 years (Foa et al 1994 ; Bi et al 2014 ), the same difficulties with other supply of active compounds: limited quantity of active compounds in tissues, low growth rate, limited localization of active ingredients in the specific organs, and destruction of the nature resource (Kazmi et al 1991 ; Frense 2007 ; Hussain et al 2013 ).…”
Section: Introductionmentioning
confidence: 99%
“…Taxol is a polyoxygenated cyclic diterpenoid, mainly used to treat numerous cancers, including ovarian, breast, lung, cervical, and pancreatic cancer [2][3][4][5] . However, limited content (0.01-0.05 %) and localization of paclitaxel in specific organs (the bark of yew) renders production from natural sources low 3,6 . Taxol biosynthesis begins with the universal diterpenoid precursor geranylgeranyl diphosphate (GGPP), which is then decorated with a series of cytochrome-P450 hydroxylases (CYP450s), acyltransferases and other enzymes, leading to the end product paclitaxel 7,8 .…”
mentioning
confidence: 99%