2024
DOI: 10.1093/infdis/jiae149
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Genetic Diversity From Proviral DNA as a Proxy for Time Since HIV-1 Infection

Marius Zeeb,
Paul Frischknecht,
Michael Huber
et al.

Abstract: HIV-1 RNA genetic diversity predicts time since infection which is important for clinical care and research. It's unclear, however, whether proviral DNA genetic diversity sampled under suppressive antiretroviral therapy can be used for this purpose. We tested whether proviral genetic diversity from NGS sequences predicts time since infection and recency in 221 people with HIV-1 with known infection time. Proviral diversity was significantly associated with time since infection (p<5*10-07, R2 up to 25%) … Show more

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“…Pre-ART PBMC DNA levels were positively associated with post-ART PBMC DNA levels, while pre-ART PBMC DNA genetic diversity differed from provirus diversity. Provirus diversity reflects the accumulated diversity over the entire infection, potentially influenced by reservoir decay and hypermutations in proviral DNA induced by APOBEC3G/F ( Tzou et al, 2020 ; Zeeb et al, 2024 ). Although no significant differences in the diversity and divergence of PBMC viral DNA were found between before and after LLV, there were obvious HIV reservoir population shifts not only across the two time points but also during the whole process of follow-up during ART.…”
Section: Discussionmentioning
confidence: 99%
“…Pre-ART PBMC DNA levels were positively associated with post-ART PBMC DNA levels, while pre-ART PBMC DNA genetic diversity differed from provirus diversity. Provirus diversity reflects the accumulated diversity over the entire infection, potentially influenced by reservoir decay and hypermutations in proviral DNA induced by APOBEC3G/F ( Tzou et al, 2020 ; Zeeb et al, 2024 ). Although no significant differences in the diversity and divergence of PBMC viral DNA were found between before and after LLV, there were obvious HIV reservoir population shifts not only across the two time points but also during the whole process of follow-up during ART.…”
Section: Discussionmentioning
confidence: 99%