Genetic diversity of East European and Asian strains of tick-borne encephalitis virus belonging to Siberian genotype

Karan, Luidmila S.; Pogodina, V V; Фролова, Т. В.; Platonov, A. Ye.

doi:10.20538/1682-0363-2006--24-35

Cited by 12 publications

(1 citation statement)

References 2 publications

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“…51 At first, based on the analysis of E protein sequences at amino acid positions 234 and 431, two genetic lineages were defined: one lineage including Zausaev strain (AF527415) was characterized by H234/ A431, whereas strains of the second lineage including Vasilchenko strain (AF069066) revealed Q234/ T431. 52,53 Later, the "Baltic lineage" 50,[54][55][56] and "European topovariant" 57 of TBEV-Sib were described. Also, the heterogenicity of TBEV-Sib was demonstrated by molecular hybridization of nucleic acids with 2 subgenotype-specific probes (designated as 3a and 3b) differentiating lineages/ subgenotypes "Vasilchenko" and "Zausaev" of Siberian subtype (Fig.…”

Section: Siberian Subtypementioning

confidence: 99%

Chapter 11: General epidemiology of TBE

Dobler¹,

Tkachev²

2023

Tick-Borne Encephalitis - The Book

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Tick-borne encephalitis virus (TBEV) exists in natural foci, which are areas where TBEV is circulating among its vectors (ticks of different species and genera) and reservoir hosts (usually rodents and small mammals). Based on phylogenetic studies, four TBEV subtypes (Far-Eastern, Siberian, European, Baikalian) and two putative subtypes (Himalayan and “178-79” group) are known. Within each subtype, some genetic lineages are described. The European subtype (TBEV-EU) (formerly known also as the “Western subtype”) of TBEV is prevalent in Europe, but it was also isolated in Western and Eastern Siberia in Russia and South Korea. The Far-Eastern subtype (TBEV-FE) was preferably found in the territory of the far-eastern part of Eurasia, but some strains were isolated in other regions of Eurasia. The Siberian (TBEV-SIB) subtype is the most common and has been found in almost all TBEV habitat areas. The Baikalian subtype is prevalent around Lake Baikal and was isolated several times from ticks and rodents. In addition to the four TBEV subtypes, one single isolate of TBEV (178-79) and two genetic sequences (Himalayan) supposed to be new TBEV subtypes were described in Eastern Siberia and China. The data on TBEV seroprevalence in humans and animals can serve as an indication for the presence or absence of TBEV in studied area.

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Section: Siberian Subtypementioning

confidence: 99%

Chapter 11: General epidemiology of TBE

Dobler¹,

Tkachev²

2023

Tick-Borne Encephalitis - The Book

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Clusteron structure of tick-borne encephalitis virus populations

Kovalev¹,

Mukhacheva²

2013

Infection, Genetics and Evolution

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a b s t r a c tTick-borne encephalitis is a natural focal transmissible zooanthroponosis. The causative agent of the disease is a tick-borne encephalitis virus (TBEV) belonging to the genus Flavivirus of the family Flaviviridae and is widespread in Eurasia. Current TBEV classification based on molecular genetic data comprises three phylogenetically separate subtypes: Far Eastern, European and Siberian (TBEV-Sib). Further differentiation of TBEV isn't developed, making it difficult to investigate the origins, distribution and evolution of the virus. In the present study we determined the nucleotide sequence of the gene E fragment for 282 TBEV-Sib isolates from Ixodes persulcatus ticks or their pools from various natural foci in Russia. Analysis of these sequences and sequences obtained from the GenBank database (more than 600), made it possible to cluster TBEV-Sib strains by identical amino acid sequences of a glycoprotein E fragment. In total, 18 groups were identified (from 3 to 285 strains in the group). It was shown that TBEV strains belonging to the same group are phylogenetically related and have a territorial attachment showing either a local or a corridor type distribution. These groups were named as clusterons showed to be the smallest unit of TBEV classification. The grouping of TBEV strains allows characterization of endemic areas both in quantitative and qualitative composition of the clusterons. The approach could be successfully used to record and monitor the TBEV populations.

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Reconsidering the classification of tick-borne encephalitis virus within the Siberian subtype gives new insights into its evolutionary history

Kovalev

Mukhacheva

2017

Infection, Genetics and Evolution

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Genetic diversity of East European and Asian strains of tick-borne encephalitis virus belonging to Siberian genotype

Cited by 12 publications

References 2 publications

Chapter 11: General epidemiology of TBE

Chapter 11: General epidemiology of TBE

Clusteron structure of tick-borne encephalitis virus populations

Reconsidering the classification of tick-borne encephalitis virus within the Siberian subtype gives new insights into its evolutionary history

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