2021
DOI: 10.1371/journal.pntd.0009419
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Genetic diversity of Francisella tularensis subsp. holarctica in Kazakhstan

Abstract: Tularemia is a highly dangerous zoonotic infection due to the bacteria Francisella tularensis. Low genetic diversity promoted the use of polymorphic tandem repeats (MLVA) as first-line assay for genetic description. Whole genome sequencing (WGS) is becoming increasingly accessible, opening the perspective of a time when WGS might become the universal genotyping assay. The main goal of this study was to describe F. tularensis strains circulating in Kazakhstan based on WGS data and develop a MLVA assay compatibl… Show more

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Cited by 12 publications
(8 citation statements)
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“…The WGS data produced in the course of this work confirms the low level of genetic diversity within subspecies mediasiatica of strains collected across a wide geographic area. This is in sharp contrast with the diversity observed for instance in subspecies holarctica over similar geographic distances [6].…”
Section: Whole-genome Sequencing (Wgs) and Phylogenetic Analysiscontrasting
confidence: 60%
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“…The WGS data produced in the course of this work confirms the low level of genetic diversity within subspecies mediasiatica of strains collected across a wide geographic area. This is in sharp contrast with the diversity observed for instance in subspecies holarctica over similar geographic distances [6].…”
Section: Whole-genome Sequencing (Wgs) and Phylogenetic Analysiscontrasting
confidence: 60%
“…The distance between the Altai focus and the place of isolation of the almost identical K-334 strain exceeds 500 km over very rough terrain. A previous investigation pointed to migratory birds as potential long-distance carriers for the spreading of F. tularensis [6]. Almost all strains of subsp.…”
Section: Discussionmentioning
confidence: 99%
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“…The distance between the Altai focus and the place of isolation of the almost identical K-334 strain exceeds 500 km over very rough terrain. A previous investigation pointed to migratory birds as potential long-distance carriers for the spreading of F. tularensis [7]. Almost all strains of subsp.…”
Section: Discussionmentioning
confidence: 99%
“…For instance, the outbreak of 2007–2018 and a lesser one in 2014 coincided with irruptions of common voles, Microtus arvalis in Castilla y León [ 39 , 40 ]. In addition, F. tularensis is present in East Kazakhstan by periodic epizootics in rodents or Spain large pneumonic outbreak was associated with direct contact with common voles, Microtus arvalis [ 41 , 42 ]. According to different reports in Iran, the epidemiological situation of the F. tularensis was introduced by the role of different rodents and hares that known as a vector and interepizootic reservoir.…”
Section: Discussionmentioning
confidence: 99%