Genetic Diversity of HBV Genotypes/
Subgenotypes and Their Correlation
with Disease Progression

Kumar, Rajesh; Singh, Jasbir

doi:10.5005/jp-journals-10018-1014

Cited by 3 publications

(3 citation statements)

References 95 publications

(106 reference statements)

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“…By virtue of population migration across East African countries could explain this alignment. Sub-genotype A2 sequences aligned with those from Martinique and Belgium as an indication of its possible origins ( 28 , 27 ). In addition, sequences of sub-genotypes A3, B and genotype C2 clustered with references sequences from Nigeria, China and Japan ( 7 , 27 ).…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Genetic Diversity of HAV and HBV Viruses among Jaundice Patients at Coast General Hospital, Mombasa County, Kenya

Kasera

Maingi

Onyango

et al. 2021

MJMS

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Background: Hepatitis A and B causes morbidity and mortality among patients. This study determined the proportion of hepatitis A, B viruses (HAV, HBV) and genetic diversity of HBV among jaundice patients at the Coast General Hospital, Mombasa County, Kenya. Methods: A cross-sectional study was conducted among 222 patients; recruited and screened for hepatitis B surface antigen (HBsAg) and anti-HAV IgM. Viral deoxyribonucleic acid (DNA) was extracted from positive samples; partial hepatitis B virus-pol (HBV-pol) gene amplified, directly sequenced and generated sequences phylogenetically analysed using MEGA X software. Demographic characteristics were compared in relation to HBV infection using Chi-square. Results: Forty-seven (21.2%) out of the 222 patients tested positive for HBV while no HAV was detected. Among those infected, n = 8 (3.6%) were females and n = 39 (17.6%) males. Forty-five samples amplified and sequenced successfully. However, two samples failed to amplify. Phylogenetic analysis revealed HBV A1 genotype [n = 35 (74.5%)] was most predominant. A3, B and C2 genotypes each occurred [n = 1 (0.02%)]. This study revealed co-existence of HBV A3, B and C2 genotypes that have not yet been detected in this region. Conclusion: HBV A1 genotype remains the predominant genotypes in this region. The detected HBV prevalence indicates possible high transmission with possibility of increasing trends of HBV genotypes based on revelation of existence of new genotypes in this region.

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Section: Discussionmentioning

confidence: 99%

Prevalence and Genetic Diversity of HAV and HBV Viruses among Jaundice Patients at Coast General Hospital, Mombasa County, Kenya

Kasera

Maingi

Onyango

et al. 2021

MJMS

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“…Progression of the viral load is dependent upon the particular genotype that the patient carries (Kumar et al, 2011). In this particular study we did not work of the genotype that the patient carried.…”

Section: Study Areamentioning

confidence: 96%

Seroprevalence of HBV infection and viral loads in outpatients attending a district hospital located in Mardan, Pakistan

2014

Int. J. Biosci.

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Hepatitis B is a major public health problem in Pakistan like other developing countries. HBV infection is a more contagious disease than HCV and HIV infection. The aim of the current study is to compare seroprevalence of HBV infection in outpatients who attended a district headquarter hospital of district Mardan, Pakistan. A total number of 270 patients were selected for this research work. Serum of patients were tested by HBsAg and ICT strip method and those found positive were sent to GCMBDR to confirmed for HBV DNA by Real Time PCR. Out of the total 270 screened patients, HBV DNA was confirmed in 94(34.81%) patients using Real Time PCR of which 56(59.6%) were male while 38(40.4%) were female outpatients. All the positive patients were divided into three categories on the bases of viral load categories such as low (<100000 IU/ml), intermediate (100,000-10,000,000 IU/ml) and high viral load (>10,000,000 IU/ml). On the bases of these categories 50 %( n=47) patients were found with low viral load, 33 %( n=31) with intermediate and 17 %( n=16) were found having high viral load. Female patients were slightly more susceptible to HBV infection compared to male patients. The highest HBV infection seroprevalence was found in patients of 21-40 age group. Majority of the sick subjects were however seen with low viral titers.

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“…The genotype D is common in the Mediterranean, Middle East, Pakistan and India region. The genotype E is found in sub-Saharan Africa and India (Kumar et al, 2011). Genotype F is found in South and Central America (Croagh et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Distribution of Hepatitis B Genotypes Among Hepatitis B Patients Visiting Decode Genomics Research Center

Pandey¹,

Bogati²,

Shrestha³

2021

Preprint

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The hepatitis B virus (HBV) is non-cytopathic, hepatotropic and enveloped virus which causes Hepatitis B and infects the liver causing inflammation and hepatocellular necrosis. The genome sequence database shows that HBV has ten genetic diversities (A-J) ten in which the HBV genotypes, I and J are the new one. Three major genotypes of HBV (A, C and D) were found in Nepal. Despite being a low prevalence, Nepal has a diversity of hepatitis B. Hence, the study aims to determine the distribution of hepatitis B genotypes among the hepatitis B patients visiting Decode Genomics Research Center. HBV genotypes were determined by using a simpler, more rapid, and more specific genotyping system for HBV involving PCR using type-specific primers. Our study showed that different HBV genotypes were identified in which genotype D to be predominant one followed by C and also showed presence of genotype A, B and F. Many recombinant genotypes were also present in our study.

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Genetic Diversity of HBV Genotypes/ Subgenotypes and Their Correlation with Disease Progression

Cited by 3 publications

References 95 publications

Prevalence and Genetic Diversity of HAV and HBV Viruses among Jaundice Patients at Coast General Hospital, Mombasa County, Kenya

Prevalence and Genetic Diversity of HAV and HBV Viruses among Jaundice Patients at Coast General Hospital, Mombasa County, Kenya

Seroprevalence of HBV infection and viral loads in outpatients attending a district hospital located in Mardan, Pakistan

Distribution of Hepatitis B Genotypes Among Hepatitis B Patients Visiting Decode Genomics Research Center

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