Genetic diversity of HLA system in two populations from Durango, Mexico: Durango city and rural Durango

González-Medina, Liliana; Barquera, Rodrigo; Delgado-Aguirre, Héctor; Clayton, Stephen; Adalid-Sáinz, Carmen; Arrieta-Bolaños, Esteban; Pacheco-Ubaldo, Hanna; Hernández-Zaragoza, Diana Iraíz; Escareño-Montiel, Néstor; Morán-Martínez, Javier; Lona-Sánchez, Abraham; González-Martínez, Marisela del Rocío; Jaramillo-Rodríguez, Yolanda; Salgado-Adame, Antonio; Cruz, Federico Juárez-de la; Zúñiga, Joaquı́n; Yunis, Edmond J.; Bekker-Méndez, Carolina; Granados, Julio

doi:10.1016/j.humimm.2019.06.005

Cited by 3 publications

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“…European populations (8 populations): England ∗ , France Lyon ∗ , Germany Essen ∗ , Ireland Northern ( Williams et al, 1999 ; Middleton et al, 2000 ), Italy ∗ , Italy Sardinia ( Grimaldi et al, 2001 ), Netherlands ∗ and Spain ( Enrich et al, 2019 ). Mexican Mestizo populations from Northern Mexico (7 populations): Baja California ( Escobedo-Ruíz et al, 2020 ), Chihuahua ( Pacheco-Ubaldo et al, 2020 ), Colima ( Barquera et al, 2020b ), Durango ( González-Medina et al, 2020 ), Nuevo León ( Barquera et al, 2020a ), Sinaloa ( Clayton et al, 2020 ), and Sonora ( Uribe-Duarte et al, 2020 ). Mexican Mestizo populations from the Center of Mexico (14 populations): Aguascalientes ( Bravo-Acevedo et al, 2020 ), Guanajuato ( Pantoja-Torres et al, 2020 ), Guerrero ( Juárez-Nicolás et al, 2020 ), Jalisco ( Bravo-Acevedo et al, 2020 ), Mexico City Center, Mexico City Western, Mexico City Eastern, Mexico City Southern, Mexico City Northern ( Barquera et al, 2020e ), Michoacán ( Ballesteros-Romero et al, 2020 ), Morelos ( Ortega-Yáñez et al, 2020 ), Nayarit ( Goné-Vázquez et al, 2020 ), Querétaro ( Martínez-Álvarez et al, 2020 ), and San Luis Potosí ( Hernández-Zaragoza et al, 2020 ).…”

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confidence: 99%

Heterogeneity of Genetic Admixture Determines SLE Susceptibility in Mexican

et al. 2021

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Systemic Lupus Erythematosus (SLE) is an autoimmune inflammatory disorder for which Major Histocompatibility Complex (MHC) genes are well identified as risk factors. SLE patients present different clinical phenotypes, which are partly explained by admixture patterns variation among Mexicans. Population genetic has insight into the high genetic variability of Mexicans, mainly described through HLA gene studies with anthropological and biomedical importance. A prospective, case-control study was performed. In this study, we recruited 146 SLE patients, and 234 healthy individuals were included as a control group; both groups were admixed Mexicans from Mexico City. The HLA typing methods were based on Next Generation Sequencing and Sequence-Based Typing (SBT). The data analysis was performed with population genetic programs and statistical packages. The admixture estimations based on HLA-B and -DRB1 revealed that SLE patients have a higher Southwestern European ancestry proportion (48 ± 8%) than healthy individuals (30 ± 7%). In contrast, Mexican Native American components are diminished in SLE patients (44 ± 1%) and augmented in Healthy individuals (63 ± 4%). HLA alleles and haplotypes’ frequency analysis found variants previously described in SLE patients from Mexico City. Moreover, a conserved extended haplotype that confers risk to develop SLE was found, the HLA-A∗29:02∼C∗16:01∼B∗44:03∼DRB1∗07:01∼DQB1∗02:02, pC = 0.02, OR = 1.41. Consistent with the admixture estimations, the origin of all risk alleles and haplotypes found in this study are European, while the protection alleles are Mexican Native American. The analysis of genetic distances supported that the SLE patient group is closer to the Southwestern European parental populace and farthest from Mexican Native Americans than healthy individuals. Heterogeneity of genetic admixture determines SLE susceptibility and protection in Mexicans. HLA sequencing is helpful to determine susceptibility alleles and haplotypes restricted to some populations.

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