Genetic Diversity of<i>Shigella</i>spp. and Their Integron Content

Eftekhari, Nazanin; Bakhshi, Bita; Pourshafie, Mohammad Reza; Zarbakhsh, B; Rahbar, Mohammad; Hajia, Massoud; Ghazvini, Kiarash

doi:10.1089/fpd.2012.1250

Cited by 28 publications

(28 citation statements)

References 31 publications

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“…still accounts for a significant proportion of bacillary dysentery in many developing countries (16). In this study, most of the Shigella isolates were resistant to ampicillin, tetracycline, and co-trimoxazole, which is in accordance with previous findings from our country (9,(17)(18)(19). These results are also in agreement with those of other studies from India (20), Chile (21), and Nepal (22).…”

Section: Discussionsupporting

confidence: 93%

“…Shigellosis is predominantly caused by S. sonnei in industrialized countries, whereas S. flexneri prevails in the developing world (17,18). In this study, S. sonnei (61.1%, n = 22) was the most common, followed by S. flexneri (27.8%, n=10), S. boydii (8.3%, n = 3), and S. dysenteriae (2.8%, n = 1).…”

Section: Discussionmentioning

confidence: 57%

“…For instance, Jomezadeh et al recently reported a higher prevalence of S. flexneri among hospitalized children with diarrhea in Abadan (9). This may suggest the possible replacement of S. flexneri by S. sonnei in some areas of Iran as the standard of living improved, as inferred from observations obtained from developed countries (17,18).…”

Section: Discussionmentioning

confidence: 79%

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Prevalence and Antibiotic Susceptibility of Shigella Species Isolated From Pediatric Patients in Tehran

Talebreza

Memariani

et al. 2015

Arch Pediatr Infect Dis

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Background: Dysentery accounts for a significant proportion of morbidity and mortality cases, especially in children with diarrhea in developing countries. Shigellosis remains a public health problem in Iran. Objectives: The objectives of this study were to investigate the presence and the frequency of Shigella spp. among children younger than 10 years with diarrhea and to determine the antimicrobial resistance patterns of these isolates in Tehran, Iran. Patients and Methods: This cross-sectional study was conducted in two pediatric hospitals in Tehran, from October, 2013 to October, 2014. Nine hundred and thirty-eight (n = 938) stool samples were collected (one stool per patient) from children less than 10 years of age. The stools were primarily cultured on MacConkey agar and xylose lysine deoxycholate (XLD). (Selenite-F broth is also used as an enrichment medium for the isolation of Shigella spp.) All of the isolates were confirmed as Shigella species by biochemical and serological tests. Molecular confirmation of Shigella isolates was determined by polymerase chain reaction (PCR) using specific primers for the ipaH gene. The antibiotic susceptibility of the Shigella isolates was tested using the Kirby-Bauer disc-diffusion method. Results: Amongst 938 stool samples, 36 were Shigella spp. S. sonnei (61.1%, n = 22), which was the most common, followed by S. flexneri (27.8%, n = 10), S. boydii (8.3%, n = 3), and S. dysenteriae (2.8%, n = 1). Furthermore, most Shigella isolates showed resistance to amoxicillin (83.3%), tetracycline (61.1%), and co-trimoxazole (83.3%). No resistance was found against ciprofloxacin and imipenem. This study showed that S. sonnei is currently the predominant species in Tehran, Iran. Conclusions: Because resistance to antibiotics changes constantly, Shigella strains should be under surveillance in order to monitor local susceptibility and subsequently formulate policies for the use of antimicrobial drugs.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 57%

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Prevalence and Antibiotic Susceptibility of Shigella Species Isolated From Pediatric Patients in Tehran

Talebreza

Memariani

et al. 2015

Arch Pediatr Infect Dis

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“…in Iran (Eftekhari et al, 2013;Seol et al, 2006;Vrints et al, 2009). Increased occurrence of resistance to antimicrobial agents among the Shigella spp.…”

Section: Discussionmentioning

confidence: 99%

Clonal dissemination of a single Shigella sonnei strain among Iranian children during Fall 2012 in Tehran, I.R. Iran

Alizadeh-Hesar

Bakhshi

Peerayeh

2015

Infection, Genetics and Evolution

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“…The developed pentaplex PCR assay is robust and is capable of providing information about target genes essential for the identification of the Shigella genus and the three Shigella species responsible for the majority of shigellosis cases [42]. Pulsed-field gel electrophoresis (PFGE) is convenient for evaluation of the clonal relatedness of the strains; however, in such geographical areas where the same clone is in circulation, use of antibiotic resistance typing and/ or plasmid profile analysis together with PFGE would be useful for precise discrimination of Shigella strains [43,44].…”

Section: Discussionmentioning

confidence: 99%

Gastroenteritis in Japanese Females Caused by Shigella flexneri without Definite Infection Route: A Case Report and Mini-Review of Literature

Usuda¹,

Yamada²,

Takeshima³

et al. 2017

J Clin Case Rep

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In Japan, the incidence of Shigellosis is low at approximately 150 cases per year, with the majority of these being imported, mainly from Asia. Sporadic domestic occurrences are also reported, the majority of which absent epidemiological association. We report a case of gastroenteritis caused by Shigella flexneri in a 60-year-old Japanese female who recovered fully following treatment with levofloxacin. While we were unable to identify the route of infection, we suspected imported frozen marine products that may have been handled or processed in an unsafe manner. Shigellosis should be included in the differential diagnosis when presented with a patient exhibiting symptoms of gastrointestinal infection, even in the absence of a history of travel to an endemic area.

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Genetic Diversity ofShigellaspp. and Their Integron Content

Cited by 28 publications

References 31 publications

Prevalence and Antibiotic Susceptibility of Shigella Species Isolated From Pediatric Patients in Tehran

Prevalence and Antibiotic Susceptibility of Shigella Species Isolated From Pediatric Patients in Tehran

Clonal dissemination of a single Shigella sonnei strain among Iranian children during Fall 2012 in Tehran, I.R. Iran

Gastroenteritis in Japanese Females Caused by Shigella flexneri without Definite Infection Route: A Case Report and Mini-Review of Literature

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