Genetic Diversity of mtDNA D-loop and Maternal Origin of Three Chinese Native Horse Breeds

Zhang, Tao; Lu, Hongzhao; Chen, Chen; Jiang, Haotian; Wu, Sanqiao

doi:10.5713/ajas.2011.11483

Cited by 14 publications

(14 citation statements)

References 25 publications

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“…Interestingly, g.66495254C 4T mutation has been found in 15 native horse breeds in China. There is evidence supports hypothesis that China is one from the earliest area of horse domestication and native China horse breeds had extensive genetic flow influenced breeds all over the world (Zhang et al, 2012). The g.66493737T 4C polymorphism known to predict optimum distance in Thoroughbred horses has been identified in four breeds (Table 4).…”

Section: Discussionsupporting

confidence: 52%

Analysis of polymorphisms in the equine MSTN gene in Polish populations of horse breeds

et al. 2016

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Section: Discussionsupporting

confidence: 52%

Analysis of polymorphisms in the equine MSTN gene in Polish populations of horse breeds

et al. 2016

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“…The haplotype diversity of Kabardian (0.980) is similar to that of the additional investigated Asian horses or higher. That also applies to comparison with other breeds like Arabian (0.784 and 0.962), Thoroughbred (0.883 and 0.942), Kazakh (0.977), Chinese (0.978 and 0.989) as well as Brazilian (varying from 0.200 to 0.944) horses (Zhang et al, 2012;Ianella et al, 2017;Othman et al, 2017). However, the Kabardian horse has a huge genetic variability in its maternal lineages representing a diverse origin and a longstanding history, which is in agreement with recently published microsatellite analysis (Duduev et al, 2014).…”

Section: Phylogenetic Analysismentioning

confidence: 92%

Genetic analysis of maternal and paternal lineages in Kabardian horses by uniparental molecular markers

Khaudov¹,

Duduev²,

Kokov³

et al. 2018

Open Vet J.

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Studies of mitochondrial DNA (mtDNA) as well as the non-recombining part of the Y chromosome help to understand the origin and distribution of maternal and paternal lineages. The Kabardian horse from Northern Caucasia which is well-known for strength, stamina and endurance in distance riding has a large gap in its breeding documentation especially in the recent past. A 309 bp fragment of the mitochondrial D-loop (156 Kabardian horses) and six mutations in Y chromosome (49 Kabardian stallions), respectively, were analyzed to get a better insight into breeding history, phylogenetic relationship to related breeds, maternal and paternal diversity and genetic structure. We found a high mitochondrial diversity represented by 64 D-loop haplotypes out of 14 haplogroups. The most frequent haplogroups were G (19.5%), L (12.3%), Q (11.7%), and B (11.0%). Although these four haplogroups are also frequently found in Asian riding horses (e.g. Buryat, Kirghiz, Mongolian, Transbaikalian, Tuvinian) the percentage of the particular haplogroups varies sometimes remarkable. In contrast, the obtained haplogroup pattern from Kabardian horse was more similar to that of breeds reared in the Middle East. No specific haplotype cluster was observed in the phylogenetic tree for Kabardian horses. On Kabardian Y chromosome, two mutations were found leading to three haplotypes with a percentage of 36.7% (haplotype HT1), 38.8% (haplotype HT2) and 24.5% (haplotype HT3), respectively. The high mitochondrial and also remarkable paternal diversity of the Kabardian horse is caused by its long history with a widely spread maternal origin and the introduction of Arabian as well as Thoroughbred influenced stallions for improvement. This high genetic diversity provides a good situation for the ongoing breed development and performance selection as well as avoiding inbreeding.

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“…The contents of A+T was richer in the mtDNA D-loop region. It was in accordance with other studies, where A+T was 55.8%, whereas C+G was 44.2% (Zhang et al, 2012), and also matched the requirement with the order of nucleotide composition of A>C>T>G with more A+T than G+C base pairs ( Ji et al, 2008). Only three of the 36 detected polymorphisms showed insertions/deletions of single base pairs; there were transitions and one transversion, which shows a shift towards transitions (Kim et al, 2009).…”

Section: Mtdna Analysissupporting

confidence: 91%

“…Only three of the 36 detected polymorphisms showed insertions/deletions of single base pairs; there were transitions and one transversion, which shows a shift towards transitions (Kim et al, 2009). The observed high haplotype and nucleotide diversity values proved to be more than the values detected by (Moridi et al, 2013) in Iranian horses, and less but quite similar to the diversity data of 0.975 and 0.977 reported in (Pérez-Gutiérrez, De la Peña & Arana, 2008) and (Zhang et al, 2012),…”

Section: Mtdna Analysissupporting

confidence: 69%

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Supplemental Information 4: Matrix of Pairwase F_ST Values

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Background. Hungarian draft is a horse breed with a recent mixed ancestry. The interest in their conservation and characterization has increased over the last few years. It was developed in the 1920s by crossing local mares with draught horses imported from France and Belgium. The aim of this work is to contribute to the characterization of the endangered Hungarian heavy draft horse populations in order to obtain useful information to implement conservation strategies for these genetic stocks.Methods. To genetically characterize the breed and to set up the basis for a conservation programme, in this present study a hypervariable region of the mithocrondial DNA (D-loop) was used to assess genetic diversity in Hungarian draft horses. Two hundred and eighty five sequences obtained in our laboratory and 419 downloaded sequences available from Genbank were analyzed. Results.One hundred and sixty-four haplotypes were revealed. Thirty-six polymorphic sites were observed. High haplotype and nucleotide diversity values (H d =0.954±0.004; π=0.028±0.0004) were identified in Hungarian populations, although they were higher within than among the total number of breeds (H d =0.972±0.002; π=0.03097±0.002). Fourteen of the previously observed seventeen haplogroups were detected. Discussion. Our samples showed a large intra-and interbreed variation. There were no clear clustering on the median joining tree. The overall information given in this work led us to consider that the genetic scenario of this breed is more likely to be due to 'ancestrally' different genetic backrounds. This study could contribute to the development of a detailed breeding plan of Hungarian draft horse and help to formulate its genetic conservation plan, with the aim of increasing the population size, but avoiding inbreeding while, on the other hand, also facilitating genetic exchange among the populations. Background. Hungarian draft is a horse breed with a recent mixed ancestry. The interest in

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Genetic Diversity of mtDNA D-loop and Maternal Origin of Three Chinese Native Horse Breeds

Cited by 14 publications

References 25 publications

Analysis of polymorphisms in the equine MSTN gene in Polish populations of horse breeds

Analysis of polymorphisms in the equine MSTN gene in Polish populations of horse breeds

Genetic analysis of maternal and paternal lineages in Kabardian horses by uniparental molecular markers

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