Genetic Diversity of Plasmodium vivax Field Isolates from the Thai–Myanmar Border during the Period of 2006–2016

Jalei, Abdifatah Abdullahi; Chai่jaroenkul, Wanna; Na‐Bangchang, Kesara

doi:10.3390/tropicalmed8040210

Cited by 3 publications

(1 citation statement)

References 41 publications

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“…However, the genetic diversity of P. vivax populations is not fully captured by this basic genotyping 19 . One longitudinal study identified 14 different Pv CSP alleles in patients at the Thai-Mayanmar border 20 while another identified 67 unique P. vivax merozoite surface protein 1 ( Pv MSP-1) haplotypes 21 . A large proportion of recurring P. vivax cases are heterologous infections and contain different parasite genotypes than acute infection 22 , with a particularly high level of genetic diversity in parasites circulating in and around Thailand 22,23 .…”

Section: Introductionmentioning

confidence: 99%

Host kinase regulation ofPlasmodium vivaxdormant and replicating liver stages

Glennon,

Wei,

Roobsoong

et al. 2023

Preprint

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Upon transmission to the liver,Plasmodium vivaxparasites form replicating schizonts, which continue to initiate blood-stage infection, or dormant hypnozoites that reactivate weeks to months after initial infection.P. vivaxphenotypes in the field vary significantly, including the ratio of schizonts to hypnozoites formed and the frequency and timing of relapse. Evidence suggests that both parasite genetics and environmental factors underly this heterogeneity. We previously demonstrated that data on the effect of a panel of kinase inhibitors with overlapping targets onPlasmodiumliver stage infection, in combination with a computational approach called kinase regression (KiR), can be used to uncover novel host regulators of infection. Here, we applied KiR to evaluate the extent to whichP. vivaxliver-stage parasites are susceptible to changes in host kinase activity. We identified a role for a subset of host kinases in regulating schizont and hypnozoite infection and schizont size and characterized overlap as well as variability in host phosphosignaling dependencies between parasite forms and across multiple patient isolates. Striking, our data point to variability in host dependencies acrossP. vivaxisolates, suggesting one possible origin of the heterogeneity observed acrossP. vivaxin the field.

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Section: Introductionmentioning

confidence: 99%

Host kinase regulation ofPlasmodium vivaxdormant and replicating liver stages

Glennon,

Wei,

Roobsoong

et al. 2023

Preprint

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Genetic diversity of Plasmodium vivax and Plasmodium falciparum field isolates from Honduras in the malaria elimination phase

Zamora,

Pinto,

Escobar

et al. 2025

Current Research in Parasitology & Vector-Borne Diseases

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Low Genetic Diversity of Plasmodium vivax Circumsporozoite Surface Protein in Clinical Isolates from Southern Thailand

Khulmanee,

Thita,

Kritsiriwutinan

et al. 2024

TropicalMed

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The genetic diversity within the circumsporozoite surface protein (PvCSP) of Plasmodium vivax, the predominant malaria species in Thailand, is primarily observed in the northwestern region along the Thailand–Myanmar border. However, as P. vivax cases shift to southern provinces, particularly Yala Province near the Thailand–Malaysia border, PvCSP diversity remains understudied. Between 2018 and 2020, 89 P. vivax isolates were collected in Yala Province, a significant malaria hotspot. Employing polymerase chain reaction amplification, restriction fragment length polymorphism (PCR-RFLP), and DNA sequencing, the gene encoding PvCSP (Pvcsp) was analyzed. All Yala P. vivax isolates belonged to the VK210 type, distinct from strains in the western region near the Myanmar border. The central repeat region of Pvcsp revealed two common peptide repeat motifs—GDRADGQPA and GDRAAGQPA—across all southern isolates. Sequence analysis identified two subtypes, with S1 more prevalent (92%) than S2 (8%). This study underscores the limited diversity of VK210 variants of P. vivax populations in southern Thailand. These baseline findings facilitate monitoring for potential new parasite variants, aiding in the future control and management of P. vivax in the region.

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Genetic Diversity of Plasmodium vivax Field Isolates from the Thai–Myanmar Border during the Period of 2006–2016

Cited by 3 publications

References 41 publications

Host kinase regulation ofPlasmodium vivaxdormant and replicating liver stages

Host kinase regulation ofPlasmodium vivaxdormant and replicating liver stages

Genetic diversity of Plasmodium vivax and Plasmodium falciparum field isolates from Honduras in the malaria elimination phase

Low Genetic Diversity of Plasmodium vivax Circumsporozoite Surface Protein in Clinical Isolates from Southern Thailand

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